PMID- 27131859
OWN - NLM
STAT- MEDLINE
DCOM- 20170315
LR  - 20170315
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 77
IP  - 6
DP  - 2016 Jun
TI  - Genetic profiles of killer-cell immunoglobulin-like receptors and HLA ligands in 
      Thai blood donors.
PG  - 470-5
LID - S0198-8859(16)30069-6 [pii]
LID - 10.1016/j.humimm.2016.04.019 [doi]
AB  - Killer-cell immunoglobulin-like receptors (KIRs) play an important role in 
      natural killer (NK) cell regulation. Interaction of KIRs with human leukocyte 
      antigen (HLA) class I molecules can transmit signals to regulate the function of 
      NK cells. In this study, the diversities of KIR genes and their ligands in 500 
      Thai blood donors were investigated. The coexistence of inhibitory KIRs (iKIR), 
      activating KIRs (aKIR) and their ligands in the same individuals were also 
      analyzed. Overall, 36 KIR genotypes were identified. The most common genotype was 
      genotype AA1 (40.8%). All individuals carried at least one iKIR-HLA pair whereas 
      18% of the individuals lacked aKIR-HLA pair. The most common compound KIR-HLA 
      profile was the presence of 3 iKIR-HLA pairs with 1 aKIR-HLA pair (21.4%). The 
      most common compound gene profile of KIR-HLA pairs was the combined presence of 
      KIR2DL3-C1, 3DL1-Bw4, 3DL2-A3/A11 and the full length KIR2DS4-its ligands (8%). 
      This study provided a comprehensive analysis of the KIR-HLA profiles in Thai 
      blood donors in regards to KIR genotypes, HLA ligands, KIR-HLA ligand pairs and 
      compound gene profiles of both iKIRs and aKIRs and their ligands. These findings 
      will be useful as baseline information for further studies in the associations of 
      KIR genes and various diseases.
CI  - Copyright (c) 2016 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Kitpoka, Pimpun
AU  - Kitpoka P
AD  - Histocompatibility and Immunogenetics Laboratory, Department of Pathology, 
      Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, 
      Thailand.
FAU - Tammakorn, Chutima
AU  - Tammakorn C
AD  - Histocompatibility and Immunogenetics Laboratory, Department of Pathology, 
      Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, 
      Thailand.
FAU - Chaisri, Suwit
AU  - Chaisri S
AD  - The Centre for Research and Development of Medical Diagnostic Laboratories 
      (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 
      40002, Thailand; Chulabhorn International College of Medicine (CICM), Thammasat 
      University Rangsit campus, Pathum Thani 12120, Thailand.
FAU - Leelayuwat, Chanvit
AU  - Leelayuwat C
AD  - The Centre for Research and Development of Medical Diagnostic Laboratories 
      (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 
      40002, Thailand; Department of Clinical Immunology and Transfusion Sciences, 
      Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, 
      Thailand.
FAU - Mongkolsuk, Tasanee
AU  - Mongkolsuk T
AD  - Histocompatibility and Immunogenetics Laboratory, Department of Pathology, 
      Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, 
      Thailand.
FAU - Thammanichanond, Duangtawan
AU  - Thammanichanond D
AD  - Histocompatibility and Immunogenetics Laboratory, Department of Pathology, 
      Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, 
      Thailand. Electronic address: duangtawan.tha@mahidol.ac.th.
LA  - eng
PT  - Journal Article
DEP - 20160427
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Blood Donors
MH  - Cytotoxicity, Immunologic/genetics
MH  - Gene Frequency
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Killer Cells, Natural/*physiology
MH  - Middle Aged
MH  - Receptors, KIR/*genetics
MH  - Thailand
MH  - Transcriptome
MH  - Young Adult
OTO - NOTNLM
OT  - HLA ligand
OT  - Haplotype
OT  - KIR
OT  - NK cell receptor
OT  - Thai
EDAT- 2016/05/02 06:00
MHDA- 2017/03/16 06:00
CRDT- 2016/05/02 06:00
PHST- 2015/08/07 00:00 [received]
PHST- 2016/04/13 00:00 [revised]
PHST- 2016/04/25 00:00 [accepted]
PHST- 2016/05/02 06:00 [entrez]
PHST- 2016/05/02 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
AID - S0198-8859(16)30069-6 [pii]
AID - 10.1016/j.humimm.2016.04.019 [doi]
PST - ppublish
SO  - Hum Immunol. 2016 Jun;77(6):470-5. doi: 10.1016/j.humimm.2016.04.019. Epub 2016 
      Apr 27.