PMID- 27131886
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20220331
IS  - 1600-0714 (Electronic)
IS  - 0904-2512 (Linking)
VI  - 45
IP  - 10
DP  - 2016 Nov
TI  - The prevalence of celiac disease in patients with geographic tongue.
PG  - 791-796
LID - 10.1111/jop.12450 [doi]
AB  - BACKGROUND: Geographic tongue (GT) is a benign inflammatory condition usually 
      involving the dorsal surface and lateral borders of the tongue. Numerous 
      etiological factors of GT have been suggested, including immunological factors; 
      genetic; atopic or allergic predisposition; emotional stress; and hormonal 
      disturbances. GT may also coexist as one of the possible manifestations of celiac 
      disease (CD). Therefore, the aim of this study was to investigate the prevalence 
      of CD, positive serologic tests for CD screening, and HLA-DQ presence in patients 
      with GT. METHODS: Tissue transglutaminase antibodies (anti-tTG), antibodies 
      against gliadin (AGA), and human leukocyte antigen (HLA) typing were assessed for 
      60 GT patients and 60 healthy control subjects. The duodenal biopsy was performed 
      in patients with positive serologic tests. RESULTS: We found that 9 (15%) GT 
      patients were positive for IgA tTG, and in those patients histological changes 
      consistent with CD were confirmed by duodenal biopsy. Only two of them reported 
      the presence of gastrointestinal symptoms. There were statistically significant 
      differences between the GT patients and control group for immunoglobulin (Ig) A 
      tTG (P = 0.03), IgG tTG (P = 0.04), IgA AGA (P = 0.04), and IgG AGA (P = 0.02). 
      CONCLUSION: The results of our study demonstrated the increased prevalence of CD 
      in patients with GT. Therefore, the clinical oral examination should be 
      considered a diagnostic tool, especially in atypical or silent forms of CD, since 
      it may contribute to provide an early diagnosis.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Cigic, Livia
AU  - Cigic L
AD  - Study of Dental Medicine, School of Medicine, University of Split, Split, 
      Croatia. liviacigic@yahoo.com, lcigic@mefst.hr.
FAU - Galic, Tea
AU  - Galic T
AD  - Study of Dental Medicine, School of Medicine, University of Split, Split, 
      Croatia.
FAU - Kero, Darko
AU  - Kero D
AD  - Study of Dental Medicine, School of Medicine, University of Split, Split, 
      Croatia.
FAU - Simunic, Miroslav
AU  - Simunic M
AD  - School of Medicine, University of Split, Split, Croatia.
AD  - Clinical Department of Internal Medicine, University Clinic of Split, Split, 
      Croatia.
FAU - Medvedec Mikic, Ivana
AU  - Medvedec Mikic I
AD  - Study of Dental Medicine, School of Medicine, University of Split, Split, 
      Croatia.
FAU - Kalibovic Govorko, Danijela
AU  - Kalibovic Govorko D
AD  - Study of Dental Medicine, School of Medicine, University of Split, Split, 
      Croatia.
FAU - Biocina Lukenda, Dolores
AU  - Biocina Lukenda D
AD  - Study of Dental Medicine, School of Medicine, University of Split, Split, 
      Croatia.
AD  - Dental clinic Split, Split, Croatia.
LA  - eng
PT  - Journal Article
DEP - 20160501
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anemia, Iron-Deficiency/epidemiology/immunology
MH  - Biopsy
MH  - Celiac Disease/diagnosis/*epidemiology/immunology
MH  - Female
MH  - Finland/epidemiology
MH  - Glossitis, Benign Migratory/diagnosis/*epidemiology/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
OTO - NOTNLM
OT  - antibodies to gliadin
OT  - celiac disease
OT  - duodenal biopsy
OT  - geographic tongue
OT  - tissue transglutaminase antibodies
EDAT- 2016/10/27 06:00
MHDA- 2017/07/25 06:00
CRDT- 2016/05/02 06:00
PHST- 2016/03/24 00:00 [accepted]
PHST- 2016/10/27 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
PHST- 2016/05/02 06:00 [entrez]
AID - 10.1111/jop.12450 [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2016 Nov;45(10):791-796. doi: 10.1111/jop.12450. Epub 2016 May 
      1.