PMID- 27131956
OWN - NLM
STAT- MEDLINE
DCOM- 20170719
LR  - 20181202
IS  - 0219-3108 (Electronic)
IS  - 1015-9584 (Linking)
VI  - 40
IP  - 1
DP  - 2017 Jan
TI  - Dexmedetomidine reduces neuropathic pain in a rat model of skin/muscle incision 
      and retraction.
PG  - 35-40
LID - S1015-9584(15)00152-9 [pii]
LID - 10.1016/j.asjsur.2015.10.009 [doi]
AB  - BACKGROUND: Dexmedetomidine has been proposed as a novel anesthetic adjuvant. 
      However, it remains unclear whether peripheral administration of dexmedetomidine 
      is safe and effective to reduce acute postoperative pain. This study aimed to 
      examine the effects of dexmedetomidine on neuropathic pain. METHODS: Adult male 
      Sprague-Dawley rats were anaesthetized and randomly allocated into four groups 
      (n = 8): Groups S, R, RD(1), and RD(5) were injected with saline, 0.5% 
      ropivacaine, 0.5% ropivacaine combined with 1 mug dexmedetomidine, and 0.5% 
      ropivacaine combined with 5 mug dexmedetomidine, respectively, around the 
      saphenous nerve. Then, the rats were subjected to skin/muscle incision and 
      retraction (SMIR) surgery in the medial thigh. Mechanical and heat sensitivity 
      was evaluated and morphology of the dorsal root ganglion (DRG) neurons was 
      observed by electron microscopy. RESULTS: Some 62.5%, 50%, 12.5%, and 25% of rats 
      developed mechanical hypersensitivity in Groups S, R, RD(1), and RD(5), 
      respectively. The number of swollen mitochondria in DRG neurons was significantly 
      more in Group S (257.2 +/- 60.9) and Group R (291.6 +/- 82.1) than in Group RD(1) 
      (97.2 +/- 33.3) and Group RD(5) (13.6 +/- 17.9). In addition, the edema in 
      endoplasmic reticulum and Golgi apparatus was decreased in Group RD(1) and Group 
      RD(5) compared with Group S and Group R. CONCLUSION: Peripheral administration of 
      dexmedetomidine improves mechanical and heat hyperalgesia and mitigates 
      postoperative pain.
CI  - Copyright (c) 2016. Published by Elsevier Taiwan.
FAU - Huang, Xizhao
AU  - Huang X
AD  - Department of Anesthesiology, Guangdong Women and Children's Hospital, Guangzhou, 
      China; Department of Anesthesiology, General Hospital of Guangzhou Military 
      Region Affiliated to Southern Medical University, Southern Medical University, 
      Guangzhou, China.
FAU - Deng, Rongfang
AU  - Deng R
AD  - Department of Anesthesiology, General Hospital of Guangzhou Military Region 
      Affiliated to Southern Medical University, Southern Medical University, 
      Guangzhou, China.
FAU - Tu, Weifeng
AU  - Tu W
AD  - Department of Anesthesiology, General Hospital of Guangzhou Military Region 
      Affiliated to Southern Medical University, Southern Medical University, 
      Guangzhou, China.
FAU - Hu, Zurong
AU  - Hu Z
AD  - Department of Anesthesiology, Guangdong Women and Children's Hospital, Guangzhou, 
      China. Electronic address: hzrong136@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160428
PL  - Netherlands
TA  - Asian J Surg
JT  - Asian journal of surgery
JID - 8900600
RN  - 0 (Amides)
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Anesthetics, Local)
RN  - 67VB76HONO (Dexmedetomidine)
RN  - 7IO5LYA57N (Ropivacaine)
SB  - IM
MH  - Amides/therapeutic use
MH  - Analgesics, Non-Narcotic/*therapeutic use
MH  - Anesthetics, Local/therapeutic use
MH  - Animals
MH  - *Dermatologic Surgical Procedures
MH  - Dexmedetomidine/*therapeutic use
MH  - Drug Administration Schedule
MH  - Drug Therapy, Combination
MH  - Injections
MH  - Male
MH  - Muscle, Skeletal/*surgery
MH  - Neuralgia/diagnosis/etiology/*prevention & control
MH  - Pain Measurement
MH  - Pain, Postoperative/diagnosis/*prevention & control
MH  - Preoperative Care
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Ropivacaine
MH  - Thigh
MH  - Treatment Outcome
OTO - NOTNLM
OT  - dexmedetomidine
OT  - dorsal root ganglion neuron
OT  - postoperative pain
OT  - ropivacaine
OT  - skin/muscle incision and retraction
EDAT- 2016/05/02 06:00
MHDA- 2017/07/20 06:00
CRDT- 2016/05/02 06:00
PHST- 2015/01/24 00:00 [received]
PHST- 2015/09/24 00:00 [revised]
PHST- 2015/10/12 00:00 [accepted]
PHST- 2016/05/02 06:00 [pubmed]
PHST- 2017/07/20 06:00 [medline]
PHST- 2016/05/02 06:00 [entrez]
AID - S1015-9584(15)00152-9 [pii]
AID - 10.1016/j.asjsur.2015.10.009 [doi]
PST - ppublish
SO  - Asian J Surg. 2017 Jan;40(1):35-40. doi: 10.1016/j.asjsur.2015.10.009. Epub 2016 
      Apr 28.