PMID- 27132121
OWN - NLM
STAT- MEDLINE
DCOM- 20180123
LR  - 20220310
IS  - 1873-2364 (Electronic)
IS  - 0960-8966 (Linking)
VI  - 26
IP  - 6
DP  - 2016 Jun
TI  - Elderly-onset familial myasthenia gravis in two siblings.
PG  - 347-9
LID - S0960-8966(15)30158-9 [pii]
LID - 10.1016/j.nmd.2016.03.005 [doi]
AB  - Myasthenia gravis (MG) occasionally occurs in a family, but elderly-onset (>/=65 
      years) familial MG has been rarely reported. We here report the case of two 
      siblings with elderly-onset MG (mean onset age: 72.5 years) and present the human 
      leukocyte antigen (HLA) profiles (HLA-A, -B, -DR) of their family. Both patients 
      developed generalized MG with elevated serum acetylcholine receptor antibody 
      titers at their seventies. Of six siblings, the two patients and one unaffected 
      sibling shared the same HLA haplotypes. Our study indicates that elderly-onset MG 
      can occur in a family and that familial occurrence of MG may be related to 
      certain HLA alleles.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Hirunagi, Tomoki
AU  - Hirunagi T
AD  - Department of Neurology, Nagoya Daiichi Red Cross Hospital, Aichi, Japan. 
      Electronic address: t-hirunagi@nagoya-1st.jrc.or.jp.
FAU - Tsujikawa, Koyo
AU  - Tsujikawa K
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Aichi, 
      Japan.
FAU - Hasegawa, Yasuhiro
AU  - Hasegawa Y
AD  - Department of Neurology, Nagoya Daini Red Cross Hospital, Aichi, Japan.
FAU - Mano, Kazuo
AU  - Mano K
AD  - Department of Neurology, Nagoya Daiichi Red Cross Hospital, Aichi, Japan.
FAU - Katsuno, Masahisa
AU  - Katsuno M
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Aichi, 
      Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160330
PL  - England
TA  - Neuromuscul Disord
JT  - Neuromuscular disorders : NMD
JID - 9111470
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Cholinergic)
SB  - IM
MH  - Age of Onset
MH  - Aged
MH  - Female
MH  - HLA Antigens/blood
MH  - Humans
MH  - Male
MH  - Myasthenia Gravis/blood/*immunology
MH  - Receptors, Cholinergic/*immunology
MH  - *Siblings
OTO - NOTNLM
OT  - Elderly-onset
OT  - Familial clustering
OT  - Familial myasthenia gravis
OT  - Human leukocyte antigen
EDAT- 2016/05/02 06:00
MHDA- 2018/01/24 06:00
CRDT- 2016/05/02 06:00
PHST- 2015/12/14 00:00 [received]
PHST- 2016/03/18 00:00 [revised]
PHST- 2016/03/28 00:00 [accepted]
PHST- 2016/05/02 06:00 [entrez]
PHST- 2016/05/02 06:00 [pubmed]
PHST- 2018/01/24 06:00 [medline]
AID - S0960-8966(15)30158-9 [pii]
AID - 10.1016/j.nmd.2016.03.005 [doi]
PST - ppublish
SO  - Neuromuscul Disord. 2016 Jun;26(6):347-9. doi: 10.1016/j.nmd.2016.03.005. Epub 
      2016 Mar 30.