PMID- 27133325 OWN - NLM STAT- MEDLINE DCOM- 20170530 LR - 20181113 IS - 2213-3763 (Electronic) IS - 0019-4832 (Print) IS - 0019-4832 (Linking) VI - 68 IP - 2 DP - 2016 Mar-Apr TI - Clinical profile and 30-day outcome of women with acute coronary syndrome as a first manifestation of ischemic heart disease: A single-center observational study. PG - 164-8 LID - S0019-4832(15)00349-1 [pii] LID - 10.1016/j.ihj.2015.08.006 [doi] AB - BACKGROUND: Gender disparity, with respect to women receiving less medical therapy, undergoing fewer invasive procedures, and experiencing worse outcome than men, has been noted in various observational and randomized trials, though guidelines on acute coronary syndrome (ACS) are gender-neutral. Indian data with focus on women with ACS are lacking. AIM: This study was undertaken to give us an insight on the clinical presentation, risk factors, and in-hospital outcome of ACS in women and at 30 days. MATERIALS AND METHODS: 133 successive cases of women presenting with ACS, who met the inclusion criteria between 2012 and 2014, were included. Cases were grouped into ST elevation myocardial infarction (STEMI), non ST elevation myocardial infarction (NSTEMI), and unstable angina (UA). RESULTS AND CONCLUSION: The mean age was 64.4+/-11 years. The mean BMI was 23.64+/-3.23kg/m(2). Diabetes was present in 58.3% in NSTEMI, 65.1% in STEMI, and 57.1% in UA group. Hypertension was found in 75% of NSTEMI, 60.2% of STEMI, and 71.4% of UA group. Severe MR was found in 11.1% of NSTEMI and 3.6% of STEMI patients. 8.3% of NSTEMI and 15.7% of STEMI patients presented in Killips class IV. Single vessel disease was most commonly found across the spectrum of ACS. 68.7% patients in STEMI group underwent primary angioplasty. 5.6% of NSTEMI and 7.2% in STEMI group had contrast-induced nephropathy (CIN). All deaths were noted in STEMI group with eight in-hospital deaths and three during 30-day follow-up period. Killips class III and IV and higher grace score (>150) were predictors of in-hospital mortality. Chronic kidney disease, ischemic mitral regurgitation, LV clot, and in-hospital cardiac arrest were associated with higher risk. CI - Copyright (c) 2016. Published by Elsevier B.V. FAU - Nanjappa, Veena AU - Nanjappa V AD - Cardiology Registrar, Fortis Hospital, Cunningham Road, Bangalore, Karnataka, India. Electronic address: veenananjappa@yahoo.co.in. FAU - Aniyathodiyil, Gopi AU - Aniyathodiyil G AD - Interventional Cardiologist, Fortis Hospital, Cunningham Road, Bangalore, Karnataka, India. FAU - Keshava, R AU - Keshava R AD - Interventional Cardiologist, Fortis Hospital, Cunningham Road, Bangalore, Karnataka, India. LA - eng PT - Journal Article PT - Observational Study DEP - 20160118 PL - India TA - Indian Heart J JT - Indian heart journal JID - 0374675 SB - IM MH - Acute Coronary Syndrome/*complications/diagnosis/epidemiology MH - Aged MH - Cause of Death/trends MH - Disease Progression MH - Electrocardiography MH - Female MH - Follow-Up Studies MH - Hospital Mortality/trends MH - Humans MH - Incidence MH - India/epidemiology MH - Middle Aged MH - Myocardial Infarction/diagnosis/epidemiology/*etiology MH - Prognosis MH - Retrospective Studies MH - *Risk Assessment MH - Risk Factors MH - Survival Rate/trends MH - Time Factors PMC - PMC4867941 OTO - NOTNLM OT - 30-day follow-up OT - Acute coronary syndrome in women OT - In-hospital outcome OT - Risk factors OT - Tertiary hospital data EDAT- 2016/05/03 06:00 MHDA- 2017/05/31 06:00 PMCR- 2017/03/01 CRDT- 2016/05/03 06:00 PHST- 2015/05/27 00:00 [received] PHST- 2015/07/22 00:00 [revised] PHST- 2015/08/04 00:00 [accepted] PHST- 2017/03/01 00:00 [pmc-release] PHST- 2016/05/03 06:00 [entrez] PHST- 2016/05/03 06:00 [pubmed] PHST- 2017/05/31 06:00 [medline] AID - S0019-4832(15)00349-1 [pii] AID - 10.1016/j.ihj.2015.08.006 [doi] PST - ppublish SO - Indian Heart J. 2016 Mar-Apr;68(2):164-8. doi: 10.1016/j.ihj.2015.08.006. Epub 2016 Jan 18.