PMID- 27133344
OWN - NLM
STAT- MEDLINE
DCOM- 20170530
LR  - 20181202
IS  - 2213-3763 (Electronic)
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 68
IP  - 2
DP  - 2016 Mar-Apr
TI  - Administration of low molecular weight and unfractionated heparin during 
      percutaneous coronary intervention.
PG  - 213-24
LID - S0019-4832(16)00015-8 [pii]
LID - 10.1016/j.ihj.2016.01.014 [doi]
AB  - This systematic review with meta-analysis sought to determine the efficacy and 
      safety of unfractionated heparin (UFH) and low molecular weight heparin (LMWH) on 
      clinical outcomes following percutaneous coronary intervention. Medline, Embase, 
      Elsevier, and web of knowledge as well as Google scholar literature were used for 
      selecting appropriate studies with randomized controlled design. After screening 
      445 studies, a total of 23 trials (including a total of 43,912 patients) were 
      identified that reported outcomes. Pooled analysis revealed that LMWH compared to 
      UFH could significantly increase thrombolysis in myocardial infarction grade 3 
      flow (p<0.001), which was associated with similar target vessel revascularization 
      (p=0.6), similar incidence of stroke (p=0.7), and significantly lower incidence 
      of re-myocardial infarction (p<0.001), major bleeding (p=0.02) and mortality 
      (p<0.001). Overall, LMWH was shown to be a useful type of heparin for patients 
      with MI undergoing PCI, due to its higher efficacy and lower rate of complication 
      compared to UFH. It is also associated with increased myocardial perfusion, 
      decreased major hemorrhage, and mortality.
CI  - Copyright (c) 2016 Cardiological Society of India. All rights reserved.
FAU - Ali-Hassan-Sayegh, Sadegh
AU  - Ali-Hassan-Sayegh S
AD  - Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran. Electronic address: S.alihassan.cardiosurg@gmail.com.
FAU - Mirhosseini, Seyed Jalil
AU  - Mirhosseini SJ
AD  - Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
FAU - Shahidzadeh, Azadeh
AU  - Shahidzadeh A
AD  - Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
FAU - Mahdavi, Parisa
AU  - Mahdavi P
AD  - Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
FAU - Tahernejad, Mahbube
AU  - Tahernejad M
AD  - Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
FAU - Haddad, Fatemeh
AU  - Haddad F
AD  - Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
FAU - Lotfaliani, Mohammad Reza
AU  - Lotfaliani MR
AD  - Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
FAU - Sabashnikov, Anton
AU  - Sabashnikov A
AD  - Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, 
      Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom.
FAU - Popov, Aron-Frederik
AU  - Popov AF
AD  - Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, 
      Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20160126
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
EIN - Indian Heart J. 2017 Sep - Oct;69(5):e1. PMID: 29054205
MH  - Anticoagulants/administration & dosage
MH  - Heparin/administration & dosage
MH  - Heparin, Low-Molecular-Weight/*administration & dosage
MH  - Humans
MH  - Injections, Intravenous
MH  - Intraoperative Complications/*prevention & control
MH  - Intraoperative Period
MH  - Myocardial Infarction/*drug therapy/*surgery
MH  - Treatment Outcome
PMC - PMC4867946
OTO - NOTNLM
OT  - Low molecular weight heparin
OT  - Myocardial infarction
OT  - Outcome
OT  - Percutaneous coronary intervention
OT  - Unfractionated heparin
EDAT- 2016/05/03 06:00
MHDA- 2017/05/31 06:00
PMCR- 2017/03/01
CRDT- 2016/05/03 06:00
PHST- 2015/07/01 00:00 [received]
PHST- 2016/01/08 00:00 [revised]
PHST- 2016/01/11 00:00 [accepted]
PHST- 2017/03/01 00:00 [pmc-release]
PHST- 2016/05/03 06:00 [entrez]
PHST- 2016/05/03 06:00 [pubmed]
PHST- 2017/05/31 06:00 [medline]
AID - S0019-4832(16)00015-8 [pii]
AID - 10.1016/j.ihj.2016.01.014 [doi]
PST - ppublish
SO  - Indian Heart J. 2016 Mar-Apr;68(2):213-24. doi: 10.1016/j.ihj.2016.01.014. Epub 
      2016 Jan 26.