PMID- 27134561
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160502
LR  - 20201001
IS  - 1450-1147 (Print)
IS  - 1607-3312 (Electronic)
IS  - 1450-1147 (Linking)
VI  - 15
IP  - 2
DP  - 2016 May-Aug
TI  - Correlation between Transient Ischemic Dilation Index and Endothelin-1 Level in 
      Patients with Type 2 Diabetes Mellitus.
PG  - 109-13
LID - 10.4103/1450-1147.167576 [doi]
AB  - Transient ischemic dilation (TID) is a sensitive and specific marker for 
      detecting the severity and extent of coronary artery disease (CAD), which is 
      closely associated with endothelial dysfunction. TID can be observed on 
      stress-rest myocardial perfusion scan (MPS) due to subendocardial hypoperfusion. 
      Hyperglycemia in type 2 diabetes mellitus (T2DM) could lead to micro- and 
      macrovascular complications and begins with endothelial dysfunction. Endothelin-1 
      (ET-1), a potent vasocontrictor, increases in endothelial dysfunction. The aim of 
      this study was to examine the correlation between TID index and ET​​-1 levels in 
      T2DM patients without any sign or symptom of cardiovascular complication. An 
      analytic-correlational cross-sectional study was done on T2DM patients who met 
      the inclusion criteria and agreed to participate by signing an informed consent 
      form. The TID index was calculated automatically using standard software provided 
      by the gamma camera GE-Infinia. Stress-rest MPS was done using technetium-99m 
      ((99m)Tc)-tetrofosmin and a pharmacological stress test using adenosine. The ET-1 
      level was determined by radioimmunoassay. Data distribution was analyzed using 
      the Shapiro-Wilk normality test. The Mann-Whitney test was used to compare the 
      average difference of the variables and Spearman's rank for correlation analysis. 
      A total of 47 subjects consisting of 24 (51%) males and 23 (49%) females were 
      included in this study. The age range was 37-74 years (54.3 +/- 8.4). The TID index 
      range was 0.86-1.26 (median = 1.12) and abnormal TID index was found in 23/47 
      (49%) subjects. ET-1 levels range 8.02-17.91 pg/mL (median = 11.08). The results 
      showed no significant differences in age, ET-1 levels, and TID index based on age 
      and sex (P > 0.05). There was a significant positive correlation between TID 
      index and ET-1 level with r = 0.7 and P < 0.001. There was a positive correlation 
      between TID index and ET-1 plasma level in patients with T2DM.
FAU - Kartamihardja, Achmad Hussein Sundawa
AU  - Kartamihardja AH
AD  - Department of Nuclear Medicine and Molecular Imaging, Universitas Padjadjaran, 
      Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - World J Nucl Med
JT  - World journal of nuclear medicine
JID - 101286955
PMC - PMC4809151
OTO - NOTNLM
OT  - Endothelial dysfunction
OT  - endothelin-1
OT  - transient ischemic dilation index
OT  - type 2 diabetes mellitus
COIS- Conflict of Interest: None declared.
EDAT- 2016/05/03 06:00
MHDA- 2016/05/03 06:01
PMCR- 2016/05/01
CRDT- 2016/05/03 06:00
PHST- 2016/05/03 06:00 [entrez]
PHST- 2016/05/03 06:00 [pubmed]
PHST- 2016/05/03 06:01 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - WJNM-15-109 [pii]
AID - 10.4103/1450-1147.167576 [doi]
PST - ppublish
SO  - World J Nucl Med. 2016 May-Aug;15(2):109-13. doi: 10.4103/1450-1147.167576.