PMID- 27134696
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160502
LR  - 20240325
IS  - 1939-4551 (Print)
IS  - 1939-4551 (Electronic)
IS  - 1939-4551 (Linking)
VI  - 9
DP  - 2016
TI  - Debates in allergy medicine: specific immunotherapy efficiency in children with 
      atopic dermatitis.
PG  - 15
LID - 10.1186/s40413-016-0106-3 [doi]
LID - 15
AB  - Allergen specific immunotherapy (AIT) has been the only pathogenetically relevant 
      treatment of IgE-mediated allergic diseases (ADs) for many years. The use of AIT 
      for atopic dermatitis (AD) treatment is dubious and has both followers and 
      opponents. The improvement of subcutaneous AIT (SCIT) and introduction of 
      Sublingual immunotherapy (SLIT) gives prospects of their application both for 
      adults and children suffering from AD. This review presents results of scientific 
      research, system and meta-analyses that confirm the clinical efficacy of AIT for 
      children with AD who has the sensitization to allergens of house dust mite, grass 
      and plant pollen suffering from co-occurring respiratory ADs and with moderate 
      and severe course of allergic AD. There have been analyzed the most advanced 
      achievements in AIT studies as well as there have been specified the unmet needs 
      in AD. The preliminary diagnostics of IgE-mediated AD and pathophysiological 
      disorders, including immune ones, will allow a doctor to develop appropriate 
      comprehensive treatment algorithm for children's AD aimed at its correction. The 
      including of AIT to the children's comprehensive therapy program is reasonable 
      only if AD has the allergic form. It is necessary better to design the randomized 
      research studies and to acquire extended clinical practice in children with AD. 
      Use of the successes of molecular-based allergy diagnostics will help to optimize 
      and personalize the process of selecting the necessary allergens to determine the 
      most appropriate vaccines for children considering the results of the allergen 
      component diagnostics. The strategy of treatment of children with AD in future 
      will be based on individual target therapy.
FAU - Slavyanakaya, Tatiana A
AU  - Slavyanakaya TA
AD  - People's Friendship University of Russia, Moscow, Moscow region Russia ; 
      Institute of Immunophysiology, Moscow, Russia.
FAU - Derkach, Vladislava V
AU  - Derkach VV
AD  - Institute of Immunophysiology, Moscow, Russia ; Pacific State Medical University, 
      Vladivostok, Russia.
FAU - Sepiashvili, Revaz I
AU  - Sepiashvili RI
AD  - People's Friendship University of Russia, Moscow, Moscow region Russia ; 
      Institute of Immunophysiology, Moscow, Russia.
LA  - eng
PT  - Journal Article
DEP - 20160418
PL  - United States
TA  - World Allergy Organ J
JT  - The World Allergy Organization journal
JID - 101481283
EIN - World Allergy Organ J. 2016 Nov 2;9(1):38. PMID: 27843531
PMC - PMC4836162
OTO - NOTNLM
OT  - Aeroallergen
OT  - Allergen specific immunotherapy
OT  - Atopic dermatitis
OT  - Children
OT  - Clinical efficacy
OT  - Subcutaneous specific immunotherapy
OT  - Sublingual specific immunotherapy
EDAT- 2016/05/03 06:00
MHDA- 2016/05/03 06:01
PMCR- 2016/04/18
CRDT- 2016/05/03 06:00
PHST- 2015/08/20 00:00 [received]
PHST- 2016/03/17 00:00 [accepted]
PHST- 2016/05/03 06:00 [entrez]
PHST- 2016/05/03 06:00 [pubmed]
PHST- 2016/05/03 06:01 [medline]
PHST- 2016/04/18 00:00 [pmc-release]
AID - S1939-4551(19)30171-1 [pii]
AID - 106 [pii]
AID - 10.1186/s40413-016-0106-3 [doi]
PST - epublish
SO  - World Allergy Organ J. 2016 Apr 18;9:15. doi: 10.1186/s40413-016-0106-3. 
      eCollection 2016.