PMID- 2713677
OWN - NLM
STAT- MEDLINE
DCOM- 19890615
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 484
IP  - 1-2
DP  - 1989 Apr 10
TI  - Laminar cortical interactions during epileptic spikes studied with principal 
      component analysis and physiological modeling.
PG  - 13-35
AB  - The direct cortical responses (DCR) to electrical stimulation and electrically 
      evoked interictal penicillin spikes (EIIS) were studied in the same rats using 
      current source-density (CSD) analysis to directly compare regions of neuronal 
      depolarization and hyperpolarization in neocortex. Principal component analysis 
      (PCA) was further used to evaluate patterns of covariance in the CSD that were 
      characteristic of interactions between pyramidal cell populations with spatially 
      and temporally distinct transmembrane currents. A physical model was applied to 
      the physiological interpretation of PCA results and the optimal model parameters 
      used to estimate neuronal generators of recorded laminar field potentials. The 
      data suggested that the DCR and EIIS were produced by the same neuronal circuit 
      which could be represented by two anatomically distinct populations of pyramidal 
      cells. The first of these populations was situated in the upper and middle layers 
      (supragranular pyramidal neurons) and formed a dipolar CSD pattern that reversed 
      polarity in layers II and III. The second deeper population (infragranular 
      pyramidal neurons) extended throughout most of the cortical thickness and formed 
      a dipolar CSD pattern that reversed polarity in layer V. We propose that 
      excitatory intracortical connections of supragranular pyramidal cells may 
      pathologically synchronize depolarization within the epileptic focus. In this 
      way, supragranular pyramidal cells may provide a trigger mechanism for interictal 
      spikes in neocortex.
FAU - Barth, D S
AU  - Barth DS
AD  - Department of Neurology, University of California, Los Angeles 90024.
FAU - Di, S
AU  - Di S
FAU - Baumgartner, C
AU  - Baumgartner C
LA  - eng
GR  - 1-R01-NS20806/NS/NINDS NIH HHS/United States
GR  - 1-R01-NS22575/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Animals
MH  - Cerebral Cortex/*physiology
MH  - Electric Stimulation
MH  - Electronic Data Processing
MH  - Epilepsy/*physiopathology
MH  - Evoked Potentials
MH  - *Models, Neurological
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Statistics as Topic
EDAT- 1989/04/10 00:00
MHDA- 1989/04/10 00:01
CRDT- 1989/04/10 00:00
PHST- 1989/04/10 00:00 [pubmed]
PHST- 1989/04/10 00:01 [medline]
PHST- 1989/04/10 00:00 [entrez]
AID - 0006-8993(89)90344-2 [pii]
AID - 10.1016/0006-8993(89)90344-2 [doi]
PST - ppublish
SO  - Brain Res. 1989 Apr 10;484(1-2):13-35. doi: 10.1016/0006-8993(89)90344-2.