PMID- 27138732 OWN - NLM STAT- MEDLINE DCOM- 20180202 LR - 20181113 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 6 DP - 2016 May 3 TI - The Association between Resting Functional Connectivity and Visual Creativity. PG - 25395 LID - 10.1038/srep25395 [doi] LID - 25395 AB - Resting-state functional connectivity (RSFC), the temporal correlation of intrinsic activation between different brain regions, has become one of the most fascinating field in the functional imaging studies. To better understand the association between RSFC and individual creativity, we used RSFC and the figure Torrance Tests of Creative Thinking (TTCT-F) to investigate the relationship between creativity measured by TTCT and RSFC within two different brain networks, default mode network and the cognitive control network, in a large healthy sample (304). We took the medial prefrontal cortex (MPFC) and the bilateral dorsolateral prefrontal cortices (DLPFC) to be the seed regions and investigated the association across subjects between the score of TTCT-F and the strength of RSFC between these seed regions and other voxels in the whole brain. Results revealed that the strength of RSFC with the MPFC was significantly and negatively correlated with the score of TTCT-F in the precuneus. Meanwhile, we also found that the strength of RSFC with the left DLPFC was significantly and positively correlated with the score of TTCT-F in the right DLPFC. It suggests that the decreased RSFC within DMN and the increased RSFC within CCN presents a potential interaction mechanism between different region for higher creativity. FAU - Li, Wenfu AU - Li W AD - School of Mental Health, Jining Medical University, Jining 272067, China. FAU - Yang, Junyi AU - Yang J AD - School of psychology, Southwest University, Chongqing 400715, China. FAU - Zhang, Qinglin AU - Zhang Q AD - School of psychology, Southwest University, Chongqing 400715, China. FAU - Li, Gongying AU - Li G AD - School of Mental Health, Jining Medical University, Jining 272067, China. FAU - Qiu, Jiang AU - Qiu J AD - School of psychology, Southwest University, Chongqing 400715, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160503 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Adult MH - Brain Mapping MH - *Creativity MH - Female MH - Humans MH - Magnetic Resonance Imaging/methods MH - Male MH - Nerve Net/diagnostic imaging/physiology MH - Prefrontal Cortex/diagnostic imaging/*physiology MH - Rest/*physiology MH - Thinking/*physiology PMC - PMC4853707 EDAT- 2016/05/04 06:00 MHDA- 2018/02/03 06:00 PMCR- 2016/05/03 CRDT- 2016/05/04 06:00 PHST- 2015/10/08 00:00 [received] PHST- 2016/04/18 00:00 [accepted] PHST- 2016/05/04 06:00 [entrez] PHST- 2016/05/04 06:00 [pubmed] PHST- 2018/02/03 06:00 [medline] PHST- 2016/05/03 00:00 [pmc-release] AID - srep25395 [pii] AID - 10.1038/srep25395 [doi] PST - epublish SO - Sci Rep. 2016 May 3;6:25395. doi: 10.1038/srep25395.