PMID- 27138871
OWN - NLM
STAT- MEDLINE
DCOM- 20180321
LR  - 20220317
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 30
IP  - 6
DP  - 2016 Aug
TI  - Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short- and 
      long-term prognosis in patients with diabetes mellitus and acute myocardial 
      infarction.
PG  - 1097-102
LID - S1056-8727(16)30109-X [pii]
LID - 10.1016/j.jdiacomp.2016.04.010 [doi]
AB  - INTRODUCTION: Platelet activation and hyperreactivity plays a pivotal role in 
      developing intravascular thrombus in ST elevation myocardial infarction (STEMI). 
      Mean platelet volume (MPV), which is readily available in clinical settings, has 
      been linked to poor prognosis following STEMI. Recently, platelet-to-lymphocyte 
      ratio (PLR) has emerged as a new marker of worse outcomes linking inflammation 
      and thrombosis. We investigated the prognostic significance of the new marker, 
      MPVLR, in diabetic patients with STEMI undergoing percutaneous coronary 
      intervention (PCI). METHODS: A total of 623 patients with diabetes mellitus and 
      STEMI undergoing primary PCI were enrolled and divided based on the median MPVLR 
      on admission into two groups: group 1 (N=266) with an MPVLR </=4.46 and group 2 
      (N=257) with an MPVLR >4,46. RESULTS: Despite similar clinical features patients 
      with elevated MPVLR (group 2) had worse angiographic characteristic suggestive of 
      a higher thrombus burden. In-hospital and one-year mortality was higher in group 
      2. ROC analysis revealed moderate diagnostic value in predicting in-hospital 
      mortality (adjusted HR 1.13; 95% CI 1.04-1.23; P=0.003; MPVLR cut-off >6.13) 
      similar to that of PLR a good diagnostic value in predicting long-term mortality 
      (adjusted HR 1.52; 95% CI 1.42-1.63; P<0.0001; MPVLR cut-off >5.88) better than 
      that of PLR. MPVLR remained an independent risk factor of early and late 
      mortality. CONCLUSIONS: To the best of our knowledge, this is the first ever 
      study that has investigated MPVLR. Despite similar clinical characteristics, 
      patients with elevated MPVLR had worse angiographic features which may indicate a 
      greater thrombus burden. Elevated MPVLR is an independent risk factor of early 
      and late mortality following STEMI. In addition, it has similar value to PLR in 
      predicting in-hospital mortality, and a better value than PLR in predicting 
      long-term mortality.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Hudzik, Bartosz
AU  - Hudzik B
AD  - Third Department of Cardiology, Silesian Center for Heart Disease, SMDZ in 
      Zabrze, Medical University of Silesia in Katowice. Electronic address: 
      bartekh@mp.pl.
FAU - Szkodzinski, Janusz
AU  - Szkodzinski J
AD  - Third Department of Cardiology, Silesian Center for Heart Disease, SMDZ in 
      Zabrze, Medical University of Silesia in Katowice.
FAU - Lekston, Andrzej
AU  - Lekston A
AD  - Third Department of Cardiology, Silesian Center for Heart Disease, SMDZ in 
      Zabrze, Medical University of Silesia in Katowice.
FAU - Gierlotka, Marek
AU  - Gierlotka M
AD  - Third Department of Cardiology, Silesian Center for Heart Disease, SMDZ in 
      Zabrze, Medical University of Silesia in Katowice.
FAU - Polonski, Lech
AU  - Polonski L
AD  - Third Department of Cardiology, Silesian Center for Heart Disease, SMDZ in 
      Zabrze, Medical University of Silesia in Katowice.
FAU - Gasior, Mariusz
AU  - Gasior M
AD  - Third Department of Cardiology, Silesian Center for Heart Disease, SMDZ in 
      Zabrze, Medical University of Silesia in Katowice.
LA  - eng
PT  - Journal Article
DEP - 20160429
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus/blood/*diagnosis/mortality
MH  - Female
MH  - Humans
MH  - Lymphocytes/*cytology
MH  - Male
MH  - *Mean Platelet Volume
MH  - Middle Aged
MH  - Myocardial Infarction/blood/*diagnosis/mortality
MH  - Prognosis
OTO - NOTNLM
OT  - Lymphocyte
OT  - Mean platelet volume (MPV)
OT  - Mean platelet volume-to-lymphocyte ratio (MPVLR)
OT  - Outcomes
OT  - Prognosis
OT  - STEMI
EDAT- 2016/05/04 06:00
MHDA- 2018/03/22 06:00
CRDT- 2016/05/04 06:00
PHST- 2016/03/28 00:00 [received]
PHST- 2016/04/11 00:00 [revised]
PHST- 2016/04/12 00:00 [accepted]
PHST- 2016/05/04 06:00 [entrez]
PHST- 2016/05/04 06:00 [pubmed]
PHST- 2018/03/22 06:00 [medline]
AID - S1056-8727(16)30109-X [pii]
AID - 10.1016/j.jdiacomp.2016.04.010 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2016 Aug;30(6):1097-102. doi: 
      10.1016/j.jdiacomp.2016.04.010. Epub 2016 Apr 29.