PMID- 27139191
OWN - NLM
STAT- MEDLINE
DCOM- 20170612
LR  - 20181113
IS  - 1936-0541 (Electronic)
IS  - 1936-0533 (Linking)
VI  - 10
IP  - 6
DP  - 2016 Nov
TI  - The potential role of liver stem cells in initiation of primary liver cancer.
PG  - 893-901
AB  - Identification of the cellular origin of primary liver cancer remains 
      challenging. Some data point toward liver stem cells (LSCs) or liver progenitor 
      cells (LPCs) not only as propagators of liver regeneration, but also as 
      initiators of liver cancer. LSCs exhibit a long lifespan and strong duplicative 
      potential upon activation and are inclined to accumulate more mutations that can 
      be passed down to the next generations. Recent evidence shows that dysregulation 
      of signaling pathways associated with self-renewal of LSCs can drive their 
      aberrant proliferation and even malignant transformation. If LSCs could be proved 
      to be an initiator of liver carcinogenesis, they would be promising for 
      ultra-early diagnosis and targeting therapy of liver cancer. This review mainly 
      summarizes the potential role of LSCs in the carcinogenesis of primary liver 
      cancer.
FAU - Zhi, Xiao-Song
AU  - Zhi XS
AD  - Center for Stem Cells and Medicine, Department of Cell Biology, Second Military 
      Medical University, 800 Xiangyin Road, Shanghai, 200433, People's Republic of 
      China.
FAU - Xiong, Jun
AU  - Xiong J
AD  - Department of Histology and Embryology, Second Military Medical University, 800 
      Xiangyin Road, Shanghai, 200433, People's Republic of China.
FAU - Zi, Xiao-Yuan
AU  - Zi XY
AD  - Center for Stem Cells and Medicine, Department of Cell Biology, Second Military 
      Medical University, 800 Xiangyin Road, Shanghai, 200433, People's Republic of 
      China. zi_xiaoyuan@163.com.
FAU - Hu, Yi-Ping
AU  - Hu YP
AD  - Center for Stem Cells and Medicine, Department of Cell Biology, Second Military 
      Medical University, 800 Xiangyin Road, Shanghai, 200433, People's Republic of 
      China. yphu@smmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160502
PL  - United States
TA  - Hepatol Int
JT  - Hepatology international
JID - 101304009
SB  - IM
MH  - Cell Transformation, Neoplastic/metabolism/*pathology
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Liver Neoplasms/metabolism/*pathology
MH  - Neoplastic Stem Cells/metabolism/*pathology
MH  - Signal Transduction
OTO - NOTNLM
OT  - Initiators
OT  - Liver carcinogenesis
OT  - Liver stem cells
OT  - Primary liver cancer
EDAT- 2016/10/28 06:00
MHDA- 2017/06/13 06:00
CRDT- 2016/05/04 06:00
PHST- 2015/08/13 00:00 [received]
PHST- 2016/04/01 00:00 [accepted]
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2017/06/13 06:00 [medline]
PHST- 2016/05/04 06:00 [entrez]
AID - 10.1007/s12072-016-9730-9 [pii]
AID - 10.1007/s12072-016-9730-9 [doi]
PST - ppublish
SO  - Hepatol Int. 2016 Nov;10(6):893-901. doi: 10.1007/s12072-016-9730-9. Epub 2016 
      May 2.