PMID- 27139301
OWN - NLM
STAT- MEDLINE
DCOM- 20180321
LR  - 20180321
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 563-564
DP  - 2016 Sep 1
TI  - Blue sharks (Prionace glauca) as bioindicators of pollution and health in the 
      Atlantic Ocean: Contamination levels and biochemical stress responses.
PG  - 282-92
LID - S0048-9697(16)30765-3 [pii]
LID - 10.1016/j.scitotenv.2016.04.085 [doi]
AB  - Marine ecosystems are constantly being threatened by contaminants produced by 
      human activities. There is an urge to better understand their impacts on marine 
      organisms and develop reliable tools for biomonitoring studies, while also 
      assessing their potential impacts on human health. Given their position on top of 
      food webs, sharks are particularly susceptible to bioaccumulation, making them 
      potential sentinel species of marine contamination. The main objective of this 
      study was to find suitable biomarkers for future marine pollution biomonitoring 
      studies by correlating biochemical responses with tissue contaminant body burden 
      in blue sharks (Prionace glauca), a species heavily caught and consumed by 
      humans, while also addressing their general health. The chemical contaminants 
      analysed comprised different persistent organic pollutants (POPs) families from 
      polychlorinated compounds to brominated flame retardants (BFRs) and 
      perfluorinated compounds (PFCs) and different trace and heavy metals. 
      Concentrations of some contaminants in sharks' tissues were found to be above the 
      legally allowed limits for human consumption. A canonical correspondence analysis 
      (CCA) was performed and some strong associations were found between biochemical 
      responses and contaminants' accumulation levels. DNA damage and lipid 
      peroxidation levels, as well as the inhibition of the antioxidant enzyme 
      glutathione peroxidase, were the main effects and consequences of contamination. 
      The impact of contamination on these vital macromolecules underlines the 
      suboptimal conditions of the sampled P. glauca, which can ultimately lead to the 
      degradation of core ecological aspects, such as swimming, feeding, and 
      reproduction. It can be concluded that P. glauca demonstrates great potential to 
      be used as environmental sentinel and suitable biomarker candidates were 
      identified in this work. Moreover, this study also highlights the risks that the 
      consumption of blue shark derived products can pose to human health, which is of 
      upmost interest as the sampled organisms were still juveniles and already 
      presented values above regulatory limits.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Alves, Luis M F
AU  - Alves LM
AD  - MARE - Marine and Environmental Sciences Centre, ESTM, Instituto Politecnico de 
      Leiria, 2520-641 Peniche, Portugal.
FAU - Nunes, Margarida
AU  - Nunes M
AD  - MARE - Marine and Environmental Sciences Centre, ESTM, Instituto Politecnico de 
      Leiria, 2520-641 Peniche, Portugal; LUNAM Universite, Oniris, USC 1329, 
      Laboratoire d'Etude des Residus et Contaminants dans les Aliments (LABERCA), 
      Nantes, France.
FAU - Marchand, Philippe
AU  - Marchand P
AD  - LUNAM Universite, Oniris, USC 1329, Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France.
FAU - Le Bizec, Bruno
AU  - Le Bizec B
AD  - LUNAM Universite, Oniris, USC 1329, Laboratoire d'Etude des Residus et 
      Contaminants dans les Aliments (LABERCA), Nantes, France.
FAU - Mendes, Susana
AU  - Mendes S
AD  - MARE - Marine and Environmental Sciences Centre, ESTM, Instituto Politecnico de 
      Leiria, 2520-641 Peniche, Portugal.
FAU - Correia, Joao P S
AU  - Correia JP
AD  - MARE - Marine and Environmental Sciences Centre, ESTM, Instituto Politecnico de 
      Leiria, 2520-641 Peniche, Portugal; Flying Sharks, 9900-361 Horta, Portugal.
FAU - Lemos, Marco F L
AU  - Lemos MF
AD  - MARE - Marine and Environmental Sciences Centre, ESTM, Instituto Politecnico de 
      Leiria, 2520-641 Peniche, Portugal.
FAU - Novais, Sara C
AU  - Novais SC
AD  - MARE - Marine and Environmental Sciences Centre, ESTM, Instituto Politecnico de 
      Leiria, 2520-641 Peniche, Portugal. Electronic address: sara.novais@ipleiria.pt.
LA  - eng
PT  - Journal Article
DEP - 20160430
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Biomarkers)
RN  - 0 (Metals, Heavy)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - Atlantic Ocean
MH  - Environmental Biomarkers/*drug effects
MH  - *Environmental Exposure
MH  - Environmental Monitoring
MH  - Female
MH  - Male
MH  - Metals, Heavy/*metabolism
MH  - Portugal
MH  - Sharks/*metabolism
MH  - Water Pollutants, Chemical/*metabolism
MH  - Water Pollution/adverse effects
OTO - NOTNLM
OT  - Biomarkers
OT  - Human health risk
OT  - Marine pollution
OT  - Oxidative stress
OT  - Sharks
OT  - Xenobiotics
EDAT- 2016/05/04 06:00
MHDA- 2018/03/22 06:00
CRDT- 2016/05/04 06:00
PHST- 2016/01/15 00:00 [received]
PHST- 2016/04/11 00:00 [revised]
PHST- 2016/04/11 00:00 [accepted]
PHST- 2016/05/04 06:00 [entrez]
PHST- 2016/05/04 06:00 [pubmed]
PHST- 2018/03/22 06:00 [medline]
AID - S0048-9697(16)30765-3 [pii]
AID - 10.1016/j.scitotenv.2016.04.085 [doi]
PST - ppublish
SO  - Sci Total Environ. 2016 Sep 1;563-564:282-92. doi: 
      10.1016/j.scitotenv.2016.04.085. Epub 2016 Apr 30.