PMID- 27142144
OWN - NLM
STAT- MEDLINE
DCOM- 20170615
LR  - 20170815
IS  - 1532-2777 (Electronic)
IS  - 0306-9877 (Linking)
VI  - 91
DP  - 2016 Jun
TI  - From organophosphate poisoning to diabetes mellitus: The incretin effect.
PG  - 53-55
LID - S0306-9877(16)30010-X [pii]
LID - 10.1016/j.mehy.2016.04.002 [doi]
AB  - Organophosphate (OP) poisoning induced disruption of glucose homeostasis is well 
      established. OP poisoning leads to accumulation of acetylcholine (ACh) due to the 
      inhibition of acetylcholinesterases (AChE). On the other hand the incidence of 
      type 2 diabetes mellitus (T2DM) is shown to rise along with the use of pesticides 
      in Southeast Asia. Attenuation of the 'incretin effect' is seen in T2DM. This 
      effect is regulated by a complex loop of mechanism involving ACh driven 
      muscarinic receptors. We hypothesize that OP poisoning leads to disruption of 
      glucose homeostasis by attenuation of the incretin effect. Inhibition of the 
      Glucagon Like Peptide-1 (GLP-1) secretion is our main focus of interest. Positive 
      finding of the hypothesis will open possibility of using incretin based treatment 
      modalities to treat or prevent acute OP induced disruption of glucose 
      homeostasis.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Rathish, D
AU  - Rathish D
AD  - Department of Pharmacology, Faculty of Medicine and Allied Sciences, Rajarata 
      University of Sri Lanka, Saliyapura, Anuradhapura, Sri Lanka. Electronic address: 
      rathishdeva@gmail.com.
FAU - Agampodi, S B
AU  - Agampodi SB
AD  - Department of Community Medicine, Faculty of Medicine and Allied Sciences, 
      Rajarata University of Sri Lanka, Saliyapura, Anuradhapura, Sri Lanka.
FAU - Jayasumana, M A C S
AU  - Jayasumana MACS
AD  - Department of Pharmacology, Faculty of Medicine and Allied Sciences, Rajarata 
      University of Sri Lanka, Saliyapura, Anuradhapura, Sri Lanka.
FAU - Siribaddana, S H
AU  - Siribaddana SH
AD  - Department of Medicine, Faculty of Medicine and Allied Sciences, Rajarata 
      University of Sri Lanka, Saliyapura, Anuradhapura, Sri Lanka.
LA  - eng
PT  - Journal Article
DEP - 20160407
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (Incretins)
RN  - 0 (Organophosphates)
RN  - 7C0697DR9I (Atropine)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - IY9XDZ35W2 (Glucose)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Acetylcholinesterase/metabolism
MH  - Animals
MH  - Atropine/therapeutic use
MH  - Diabetes Mellitus, Type 2/*drug therapy/*prevention & control
MH  - Endocrine System
MH  - Glucagon-Like Peptide 1/metabolism
MH  - Glucose/metabolism
MH  - Homeostasis
MH  - Humans
MH  - Incretins/*metabolism
MH  - Models, Theoretical
MH  - Organophosphate Poisoning/*drug therapy
MH  - Organophosphates/toxicity
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Acetylcholine
OT  - Atropine
OT  - Glucagon Like Peptide-1
OT  - Glucose homeostasis
OT  - Incretins
OT  - Organophosphate
OT  - Type 2 diabetes mellitus
EDAT- 2016/05/05 06:00
MHDA- 2017/06/16 06:00
CRDT- 2016/05/05 06:00
PHST- 2016/01/28 00:00 [received]
PHST- 2016/04/02 00:00 [accepted]
PHST- 2016/05/05 06:00 [entrez]
PHST- 2016/05/05 06:00 [pubmed]
PHST- 2017/06/16 06:00 [medline]
AID - S0306-9877(16)30010-X [pii]
AID - 10.1016/j.mehy.2016.04.002 [doi]
PST - ppublish
SO  - Med Hypotheses. 2016 Jun;91:53-55. doi: 10.1016/j.mehy.2016.04.002. Epub 2016 Apr 
      7.