PMID- 27142700 OWN - NLM STAT- MEDLINE DCOM- 20170911 LR - 20220330 IS - 1476-069X (Electronic) IS - 1476-069X (Linking) VI - 15 IP - 1 DP - 2016 May 4 TI - Concentrations of persistent organic pollutants in maternal and cord blood from the maternal-infant research on environmental chemicals (MIREC) cohort study. PG - 59 LID - 10.1186/s12940-016-0143-y [doi] LID - 59 AB - BACKGROUND: Pregnant women are an especially important population to monitor for environmental exposures given the vulnerability of the developing fetus. During pregnancy and lactation chemical body burdens may change due to the significant physiological changes that occur. Developmental exposures to some persistent organic pollutants (POPs) have been linked with adverse health outcomes. METHODS: First trimester maternal and cord blood plasma concentrations of several POPs including polychlorinated biphenyls (PCBs), organochlorine pesticides (OCs), polybrominated diphenyl ethers (PBDE)s and perfluoroalkyl substances (PFASs) were measured in samples from 1983 pregnant women enrolled in the Maternal-Infant Research on Environmental Chemicals (MIREC) cohort. Predictors of exposure were also identified. RESULTS: In maternal plasma, there was >90 % detection for the perfluoroalkyl substances (PFASs) perfluorooctanoic acid (PFOA), perfluoroctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and dichlorodiphenyldichloroethylene (DDE), oxychlordane and PCB 138 and 153. Cord blood plasma had much lower detection rates with low or very limited detection for most PCBs and PBDEs. The PFASs were the most frequently detected (23-64 %) chemical class in cord plasma. In a subset of 1st and 3rd trimester paired samples, PFAS concentrations were found to be strongly correlated and had ICCs ranging from 0.64 (PFOA) to 0.83 (PFHxS). The cord:maternal plasma concentration ratios ranged from 0.14 (PFOS) to 0.87 (oxychlordane, lipid adjusted). Similar to other studies, we found parity, maternal age, income, education, smoking status, pre-pregnancy BMI and fish consumption to be significant predictors for most chemicals. Those participants who were foreign-born had significantly higher concentrations of organochlorinated pesticides and PCBs. CONCLUSIONS: In the MIREC study, multiple chemical contaminants were quantified in the plasma of pregnant women. In cord plasma PFOA had the highest detection rate. However, compared to other Canadian and international population studies, the MIREC participants had lower contaminant concentrations of these substances. FAU - Fisher, Mandy AU - Fisher M AD - Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada. mandy.fisher@hc-sc.gc.ca. AD - Population Studies Division, Environmental Health Science and Research Bureau, Environmental and Radiation Health Sciences Directorate, Health Canada, 50 Columbine Driveway, Tunney's Pasture, Ottawa, AL 0801A K1A 0K9, Canada. mandy.fisher@hc-sc.gc.ca. FAU - Arbuckle, Tye E AU - Arbuckle TE AD - Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada. FAU - Liang, Chun Lei AU - Liang CL AD - Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada. FAU - LeBlanc, Alain AU - LeBlanc A AD - Le Centre de toxicologie du Quebec, Institut nationale de sante publique du Quebec, Quebec, QC, Canada. FAU - Gaudreau, Eric AU - Gaudreau E AD - Le Centre de toxicologie du Quebec, Institut nationale de sante publique du Quebec, Quebec, QC, Canada. FAU - Foster, Warren G AU - Foster WG AD - Department of Obstetrics and Gynecology, Division of Reproductive Biology, McMaster University, Hamilton, ON, Canada. FAU - Haines, Douglas AU - Haines D AD - Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada. FAU - Davis, Karelyn AU - Davis K AD - Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada. FAU - Fraser, William D AU - Fraser WD AD - Centre hospitalier universitaire de Sherbrook (CHUS), Sherbrooke, QC, Canada. LA - eng PT - Journal Article DEP - 20160504 PL - England TA - Environ Health JT - Environmental health : a global access science source JID - 101147645 RN - 0 (Alkanesulfonic Acids) RN - 0 (Caprylates) RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) RN - 0 (Halogenated Diphenyl Ethers) RN - 0 (Pesticides) RN - 947VD76D3L (perfluorooctanoic acid) RN - 9H2MAI21CL (perfluorooctane sulfonic acid) RN - DFC2HB4I0K (Polychlorinated Biphenyls) RN - FX3WJ41CMX (perflexane) SB - IM MH - Adult MH - Alkanesulfonic Acids/blood MH - Canada MH - Caprylates/blood MH - Cities MH - Cohort Studies MH - Environmental Monitoring MH - Environmental Pollutants/*blood MH - Female MH - Fetal Blood/*chemistry MH - Fluorocarbons/blood MH - Halogenated Diphenyl Ethers/blood MH - Humans MH - Infant, Newborn MH - Male MH - Pesticides/blood MH - Polychlorinated Biphenyls/blood MH - Pregnancy PMC - PMC4855498 OTO - NOTNLM OT - Cord plasma OT - DDT OT - Maternal plasma OT - PBDEs OT - PCBs OT - PFASs OT - POPs OT - Pregnant EDAT- 2016/05/05 06:00 MHDA- 2017/09/12 06:00 PMCR- 2016/05/04 CRDT- 2016/05/05 06:00 PHST- 2015/07/17 00:00 [received] PHST- 2016/04/25 00:00 [accepted] PHST- 2016/05/05 06:00 [entrez] PHST- 2016/05/05 06:00 [pubmed] PHST- 2017/09/12 06:00 [medline] PHST- 2016/05/04 00:00 [pmc-release] AID - 10.1186/s12940-016-0143-y [pii] AID - 143 [pii] AID - 10.1186/s12940-016-0143-y [doi] PST - epublish SO - Environ Health. 2016 May 4;15(1):59. doi: 10.1186/s12940-016-0143-y.