PMID- 27143268
OWN - NLM
STAT- MEDLINE
DCOM- 20170601
LR  - 20231213
IS  - 1862-1783 (Electronic)
IS  - 1673-1581 (Print)
IS  - 1673-1581 (Linking)
VI  - 17
IP  - 5
DP  - 2016 May
TI  - High correlation of specific IgE sensitization between birch pollen, soy and 
      apple allergens indicates pollen-food allergy syndrome among birch pollen 
      allergic patients in northern China.
PG  - 399-404
LID - 10.1631/jzus.B1500279 [doi]
AB  - BACKGROUND: Birch pollen sensitization and associated pollen-food syndrome among 
      Chinese allergic patients have not been investigated. METHODS: Sera from 203 
      allergic patients from the northern part of China and collected during February 
      to July 2014 were investigated. Specific immunoglobulin E (IgE) against birch 
      pollen extract Bet v and major birch pollen allergen Bet v 1 were measured using 
      the ADVIA Centaur. The presence of major apple allergen Mal d 1 and soy bean 
      allergen Gly m 4 specific IgE was measured by ImmunoCAP 100. RESULTS: Among the 
      203 sera, 34 sera (16.7%) had specific IgE to Bet v and of these, 28 sera (82.4%) 
      contained Bet v 1-specific IgE. Among the 28 sera with Bet v 1-specific IgE, 27 
      sera (96.4%) contained Mal d 1-specific IgE and 22 sera (78.6%) contained Gly m 
      4-specific IgE. Of the 34 Bet v-positive sera, 6 sera (17.6%) contained no 
      specific IgE for Bet v 1, Mal d 1, or Gly m 4. Almost all Bet v-positive sera 
      were donated during the birch pollen season. CONCLUSIONS: The prevalence of birch 
      allergy among patients visiting health care during pollen season can be as high 
      as 16.7% in Tangshan City. The majority of Chinese birch allergic patients are 
      IgE-sensitized to the major birch pollen allergen Bet v 1 as well as to the major 
      apple allergen Mal d 1 and soy bean allergen Gly m 4. A relatively high number of 
      patients (17.6%) are IgE-sensitized to birch pollen allergen(s) other than Bet v 
      1. The high prevalence of specific IgE to Mal d 1 and Gly m 4 among Bet v 
      1-sensitized patients indicates that pollen-food allergy syndrome could be of 
      clinical relevance in China.
FAU - Hao, Guo-Dong
AU  - Hao GD
AD  - Department of Allergy, Tangshan Gongren Hospital, Tangshan 063000, China.
FAU - Zheng, Yi-Wu
AU  - Zheng YW
AD  - ALK China Research, ALK, Guangzhou 510300, China.
FAU - Wang, Zhi-Xiang
AU  - Wang ZX
AD  - Department of Allergy, Tangshan Gongren Hospital, Tangshan 063000, China.
FAU - Kong, Xing-Ai
AU  - Kong XA
AD  - Department of Allergy, Tangshan Gongren Hospital, Tangshan 063000, China.
FAU - Song, Zhi-Jing
AU  - Song ZJ
AD  - Department of Allergy, Tangshan Gongren Hospital, Tangshan 063000, China.
FAU - Lai, Xu-Xin
AU  - Lai XX
AD  - ALK China Research, ALK, Guangzhou 510300, China.
FAU - Spangfort, Michael D
AU  - Spangfort MD
AD  - ALK China Research, ALK, Guangzhou 510300, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Zhejiang Univ Sci B
JT  - Journal of Zhejiang University. Science. B
JID - 101236535
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 0 (Plant Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Allergens/*chemistry
MH  - Antigens, Plant/chemistry
MH  - Betula
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Food Hypersensitivity/*immunology
MH  - Humans
MH  - Immunoglobulin E/*chemistry
MH  - Malus/*chemistry
MH  - Middle Aged
MH  - Plant Proteins/chemistry
MH  - Pollen/*chemistry
MH  - Rhinitis, Allergic, Seasonal/immunology
MH  - Glycine max/*chemistry
MH  - Young Adult
PMC - PMC4868831
OTO - NOTNLM
OT  - Apple
OT  - Birch
OT  - Cross-reaction
OT  - Pollen-food allergy
OT  - Soy
OT  - Specific immunoglobulin E (IgE)
COIS- Compliance with ethics guidelines: Guo-dong HAO, Yi-wu ZHENG, Zhi-xiang WANG, 
      Xing-ai KONG, Zhi-jing SONG, Xu-xin LAI, and Michael D. SPANGFORT declare that 
      they have no conflict of interest. All procedures followed were in accordance 
      with the ethical standards of the responsible committee on human experimentation 
      (institutional and national) and with the Helsinki Declaration of 1975, as 
      revised in 2008 (5). Informed consent was obtained from all patients for being 
      included in this study.
EDAT- 2016/05/05 06:00
MHDA- 2017/06/02 06:00
PMCR- 2016/05/01
CRDT- 2016/05/05 06:00
PHST- 2016/05/05 06:00 [entrez]
PHST- 2016/05/05 06:00 [pubmed]
PHST- 2017/06/02 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - 10.1631/jzus.B1500279 [doi]
PST - ppublish
SO  - J Zhejiang Univ Sci B. 2016 May;17(5):399-404. doi: 10.1631/jzus.B1500279.