PMID- 27144065
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160504
LR  - 20231105
IS  - 2095-3941 (Print)
IS  - 2095-3941 (Linking)
VI  - 13
IP  - 1
DP  - 2016 Mar
TI  - Changing the paradigm: the potential for targeted therapy in laryngeal squamous 
      cell carcinoma.
PG  - 87-100
LID - 10.28092/j.issn.2095-3941.2016.0010 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC) remains a highly morbid and fatal 
      disease. Historically, it has been a model example for organ preservation and 
      treatment stratification paradigms. Unfortunately, survival for LSCC has 
      stagnated over the past few decades. As the era of next-generation sequencing and 
      personalized treatment for cancer approaches, LSCC may be an ideal disease for 
      consideration of further treatment stratification and personalization. Here, we 
      will discuss the important history of LSCC as a model system for organ 
      preservation, unique and potentially targetable genetic signatures of LSCC, and 
      methods for bringing stratified, personalized treatment strategies to the 21(st) 
      century.
FAU - Ludwig, Megan L
AU  - Ludwig ML
AD  - Department of Otolaryngology, Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, MI 48109, USA; Cellular and Molecular Biology Program, 
      University of Michigan, Ann Arbor, MI 48109, USA.
FAU - Birkeland, Andrew C
AU  - Birkeland AC
AD  - Department of Otolaryngology, Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, MI 48109, USA.
FAU - Hoesli, Rebecca
AU  - Hoesli R
AD  - Department of Otolaryngology, Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, MI 48109, USA.
FAU - Swiecicki, Paul
AU  - Swiecicki P
AD  - Department of Hematology Oncology, University of Michigan Medical School, Ann 
      Arbor, MI 48109, USA.
FAU - Spector, Matthew E
AU  - Spector ME
AD  - Department of Otolaryngology, Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University 
      of Michigan Medical School, Ann Arbor, MI 48109, USA.
FAU - Brenner, J Chad
AU  - Brenner JC
AD  - Department of Otolaryngology, Head and Neck Surgery, University of Michigan 
      Medical School, Ann Arbor, MI 48109, USA; Cellular and Molecular Biology Program, 
      University of Michigan, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, 
      University of Michigan Medical School, Ann Arbor, MI 48109, USA.
LA  - eng
GR  - T32 DC005356/DC/NIDCD NIH HHS/United States
GR  - T32 GM007315/GM/NIGMS NIH HHS/United States
GR  - U01 DE025184/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PL  - China
TA  - Cancer Biol Med
JT  - Cancer biology & medicine
JID - 101588850
PMC - PMC4850131
OTO - NOTNLM
OT  - Head and neck cancer
OT  - genetics
OT  - laryngeal squamous cell carcinoma
OT  - personalized medicine
OT  - targeted therapy
EDAT- 2016/05/05 06:00
MHDA- 2016/05/05 06:01
PMCR- 2016/03/01
CRDT- 2016/05/05 06:00
PHST- 2016/05/05 06:00 [entrez]
PHST- 2016/05/05 06:00 [pubmed]
PHST- 2016/05/05 06:01 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - 10.28092/j.issn.2095-3941.2016.0010 [doi]
PST - ppublish
SO  - Cancer Biol Med. 2016 Mar;13(1):87-100. doi: 10.28092/j.issn.2095-3941.2016.0010.