PMID- 27144379
OWN - NLM
STAT- MEDLINE
DCOM- 20170424
LR  - 20220310
IS  - 1752-8062 (Electronic)
IS  - 1752-8054 (Print)
IS  - 1752-8054 (Linking)
VI  - 9
IP  - 3
DP  - 2016 Jun
TI  - Human Embryonic Stem Cell Therapy in Chronic Spinal Cord Injury: A Retrospective 
      Study.
PG  - 168-75
LID - 10.1111/cts.12394 [doi]
AB  - Human embryonic stem cells (hESCs) have a role in treating neurological 
      disorders. The efficacy and safety of hESC in treating spinal cord injury (SCI) 
      was reported in our previous study. In the present study, we have evaluated the 
      efficacy and safety of hESC therapy in 226 patients with SCI. In the first 
      treatment phase (T1), 0.25 mL hESCs were administered intramuscularly twice 
      daily, 1 mL every 10 days i.v., and 1-5 mL every 7 days. Of 153 patients in the 
      American Spinal Injury Association (ASIA) scale A at the beginning of T1, a 
      significant number of patients (n = 80; 52.3%) moved to lower scales at the end 
      of T1 (p = 0.01). At the end of T2, of 32 patients in ASIA scale A, 12 patients 
      (37.5%) moved to scale B (p = 0.01). Of 19 patients, 3 patients (37.5%) moved to 
      scale B at the end of T3 (p = 0.02). No serious adverse events (AEs) were 
      observed. hESC transplantation is safe and effective.
CI  - (c) 2016 The Authors. Clinical and Translational Science published by Wiley 
      Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and 
      Therapeutics.
FAU - Shroff, G
AU  - Shroff G
AD  - Nutech Mediworld, New Delhi, India.
LA  - eng
PT  - Journal Article
DEP - 20160503
PL  - United States
TA  - Clin Transl Sci
JT  - Clinical and translational science
JID - 101474067
SB  - IM
MH  - Adult
MH  - Cell Line
MH  - Chronic Disease
MH  - Female
MH  - Human Embryonic Stem Cells/*cytology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Patient Admission
MH  - Patient Discharge
MH  - Retrospective Studies
MH  - Spinal Cord Injuries/*therapy
MH  - *Stem Cell Transplantation/adverse effects
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC5351327
EDAT- 2016/05/05 06:00
MHDA- 2017/04/25 06:00
PMCR- 2016/06/01
CRDT- 2016/05/05 06:00
PHST- 2015/11/05 00:00 [received]
PHST- 2016/03/28 00:00 [accepted]
PHST- 2016/05/05 06:00 [entrez]
PHST- 2016/05/05 06:00 [pubmed]
PHST- 2017/04/25 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - CTS12394 [pii]
AID - 10.1111/cts.12394 [doi]
PST - ppublish
SO  - Clin Transl Sci. 2016 Jun;9(3):168-75. doi: 10.1111/cts.12394. Epub 2016 May 3.