PMID- 2714534
OWN - NLM
STAT- MEDLINE
DCOM- 19890622
LR  - 20190908
IS  - 0272-0590 (Print)
IS  - 0272-0590 (Linking)
VI  - 12
IP  - 2
DP  - 1989 Feb
TI  - Developmental toxicity of 2,3,4,7,8-pentachlorodibenzofuran in the Fischer 344 
      rat.
PG  - 358-66
AB  - Fischer 344 rats were exposed acutely to 2,3,4,7,8-pentachlorodibenzofuran 
      (4-PeCDF) during the organogenic period to evaluate its potential as an inducer 
      of teratogenic and embryolethal effects. All dams were treated by gavage with a 
      single dose of 0, 30, 100, or 300 micrograms 4-PeCDF/kg body wt on gestation Day 
      (gd) 8, 10, or 12. An additional treatment group was included on gd 12 and 
      administered 10 micrograms 4-PeCDF/kg body wt po. All animals were killed on gd 
      20 and maternal and fetal toxicities were assessed. Determination of 
      embryotoxicity involved both soft tissue and skeletal examinations. 4-PeCDF 
      induced a dose-related decrease in corrected maternal weight gain following 
      treatment on gd 8 and 10, as well as resulted in a concomitant increase in the 
      liver/body weight ratios, first evident at 30 micrograms/kg for all 3 days of 
      exposure. The maternal thymus weight decreased relative to body weight compared 
      with those of controls. Embryo-fetal toxicity was evident from the high mortality 
      (greater than 80%) observed at 300 micrograms/kg for all 3 days of exposure. Mean 
      fetal weight, a sensitive indicator of fetal toxicity, decreased compared to that 
      of controls at 30, 100, and 300 micrograms/kg following treatment on either gd 8, 
      10, or 12.4-PeCDF induced cleft palate in survivors at a dose of 300 
      micrograms/kg for all 3 days of exposure. In conclusion, 4-PeCDF is maternally 
      and fetally toxic regardless of the gestation day of exposure, but induced terata 
      only at doses where overt maternal and fetal toxicity were observed, in contrast 
      to previously reported studies in the mice where teratogenic effects were 
      observed at nonfetotoxic dose levels. Thus, the mouse may be a more sensitive 
      model for evaluating specific toxic responses induced prenatally following 
      exposure to the structurally related polyhalogenated aromatic hydrocarbons which 
      include the dioxins, furans, biphenyls, and naphthalenes.
FAU - Couture, L A
AU  - Couture LA
AD  - Systemic Toxicology Branch, National Institute of Environmental Health Sciences, 
      Research Triangle Park, North Carolina 27709.
FAU - Harris, M W
AU  - Harris MW
FAU - Birnbaum, L S
AU  - Birnbaum LS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fundam Appl Toxicol
JT  - Fundamental and applied toxicology : official journal of the Society of 
      Toxicology
JID - 8200838
RN  - 0 (Benzofurans)
RN  - 0 (Teratogens)
RN  - U4C2RV3124 (2,3,4,7,8-pentachlorodibenzofuran)
SB  - IM
MH  - Animals
MH  - Benzofurans/*toxicity
MH  - Body Weight/drug effects
MH  - Female
MH  - Fetus/drug effects
MH  - Gestational Age
MH  - Male
MH  - Organ Size/drug effects
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred F344
MH  - *Teratogens
EDAT- 1989/02/01 00:00
MHDA- 1989/02/01 00:01
CRDT- 1989/02/01 00:00
PHST- 1989/02/01 00:00 [pubmed]
PHST- 1989/02/01 00:01 [medline]
PHST- 1989/02/01 00:00 [entrez]
AID - 10.1016/0272-0590(89)90052-3 [doi]
PST - ppublish
SO  - Fundam Appl Toxicol. 1989 Feb;12(2):358-66. doi: 10.1016/0272-0590(89)90052-3.