PMID- 27146044 OWN - NLM STAT- MEDLINE DCOM- 20161213 LR - 20220409 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 16 DP - 2016 May 4 TI - A history of childhood trauma is associated with slower improvement rates: Findings from a one-year follow-up study of patients with a first-episode psychosis. PG - 126 LID - 10.1186/s12888-016-0827-4 [doi] LID - 126 AB - BACKGROUND: The aim of this study was to investigate whether childhood trauma was associated with more severe clinical features in patients with first-episode psychosis, both at the initial assessment and after one year. METHODS: Ninety-six patients with a first-episode of a DSM-IV diagnosis of psychosis, in addition to 264 healthy controls from the same catchment area, were recruited to the TOP NORMENT study. A history of childhood trauma was obtained using the Childhood Trauma Questionnaire (CTQ). Function and symptom severity were measured using the Global Assessment of Functioning (GAF) Scale divided into function (GAF-F) and symptoms (GAF-S), the Positive and Negative Syndrome Scale (PANSS) and the Young Mania Rating Scale (YMRS). All clinical assessments were completed at two time points: At an initial assessment within the first year of initiating treatment for psychosis and after one year. RESULTS: Childhood trauma was associated with significantly reduced global functioning and more severe clinical symptoms at both baseline and follow-up, whereas emotional neglect was associated with a significantly reduced improvement rate for global functioning (GAF-F) over the follow-up period. CONCLUSION: Our data indicate that patients with first-episode psychosis who report a history of childhood trauma constitute a subgroup characterized by more severe clinical features over the first year of treatment, as well as slower improvement rates. FAU - Aas, Monica AU - Aas M AD - Division of Mental Health and Addiction, Institute of Clinical Medicine, NORMENT K.G Jebsen Centre for Psychosis Research, TOP study group, University of Oslo and Oslo University Hospital, Bygg 49, Ulleval sykehus, PO Box 4956, Nydalen, 0424, Oslo, Norway. monica.aas@medisin.uio.no. FAU - Andreassen, Ole A AU - Andreassen OA AD - Division of Mental Health and Addiction, Institute of Clinical Medicine, NORMENT K.G Jebsen Centre for Psychosis Research, TOP study group, University of Oslo and Oslo University Hospital, Bygg 49, Ulleval sykehus, PO Box 4956, Nydalen, 0424, Oslo, Norway. FAU - Aminoff, Sofie R AU - Aminoff SR AD - Division of Mental Health and Addiction, Institute of Clinical Medicine, NORMENT K.G Jebsen Centre for Psychosis Research, TOP study group, University of Oslo and Oslo University Hospital, Bygg 49, Ulleval sykehus, PO Box 4956, Nydalen, 0424, Oslo, Norway. AD - Department of Specialized Inpatient Treatment, Division of Mental Health Services, Akershus University Hospital, Oslo, Norway. FAU - Faerden, Ann AU - Faerden A AD - Division of Mental Health and Addiction, Institute of Clinical Medicine, NORMENT K.G Jebsen Centre for Psychosis Research, TOP study group, University of Oslo and Oslo University Hospital, Bygg 49, Ulleval sykehus, PO Box 4956, Nydalen, 0424, Oslo, Norway. FAU - Romm, Kristin L AU - Romm KL AD - Division of Mental Health and Addiction, Institute of Clinical Medicine, NORMENT K.G Jebsen Centre for Psychosis Research, TOP study group, University of Oslo and Oslo University Hospital, Bygg 49, Ulleval sykehus, PO Box 4956, Nydalen, 0424, Oslo, Norway. FAU - Nesvag, Ragnar AU - Nesvag R AD - Department of Genetics, Environment and Mental Health, Norwegian Institute of Public Health, Oslo, Norway. FAU - Berg, Akiah O AU - Berg AO AD - Division of Mental Health and Addiction, Institute of Clinical Medicine, NORMENT K.G Jebsen Centre for Psychosis Research, TOP study group, University of Oslo and Oslo University Hospital, Bygg 49, Ulleval sykehus, PO Box 4956, Nydalen, 0424, Oslo, Norway. FAU - Simonsen, Carmen AU - Simonsen C AD - Division of Mental Health and Addiction, Institute of Clinical Medicine, NORMENT K.G Jebsen Centre for Psychosis Research, TOP study group, University of Oslo and Oslo University Hospital, Bygg 49, Ulleval sykehus, PO Box 4956, Nydalen, 0424, Oslo, Norway. FAU - Agartz, Ingrid AU - Agartz I AD - Division of Mental Health and Addiction, Institute of Clinical Medicine, NORMENT K.G Jebsen Centre for Psychosis Research, TOP study group, University of Oslo and Oslo University Hospital, Bygg 49, Ulleval sykehus, PO Box 4956, Nydalen, 0424, Oslo, Norway. AD - Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway. FAU - Melle, Ingrid AU - Melle I AD - Division of Mental Health and Addiction, Institute of Clinical Medicine, NORMENT K.G Jebsen Centre for Psychosis Research, TOP study group, University of Oslo and Oslo University Hospital, Bygg 49, Ulleval sykehus, PO Box 4956, Nydalen, 0424, Oslo, Norway. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160504 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 SB - IM MH - Adolescent MH - Adult MH - Child Behavior Disorders/*physiopathology MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Psychotic Disorders/physiopathology/*psychology/*therapy MH - Risk Factors MH - *Severity of Illness Index PMC - PMC4855869 EDAT- 2016/05/06 06:00 MHDA- 2016/12/15 06:00 PMCR- 2016/05/04 CRDT- 2016/05/06 06:00 PHST- 2015/05/23 00:00 [received] PHST- 2016/04/22 00:00 [accepted] PHST- 2016/05/06 06:00 [entrez] PHST- 2016/05/06 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] PHST- 2016/05/04 00:00 [pmc-release] AID - 10.1186/s12888-016-0827-4 [pii] AID - 827 [pii] AID - 10.1186/s12888-016-0827-4 [doi] PST - epublish SO - BMC Psychiatry. 2016 May 4;16:126. doi: 10.1186/s12888-016-0827-4.