PMID- 27146710
OWN - NLM
STAT- MEDLINE
DCOM- 20171120
LR  - 20181113
IS  - 1573-7217 (Electronic)
IS  - 0167-6806 (Print)
IS  - 0167-6806 (Linking)
VI  - 157
IP  - 2
DP  - 2016 Jun
TI  - Cold thermal injury from cold caps used for the prevention of 
      chemotherapy-induced alopecia.
PG  - 395-400
LID - 10.1007/s10549-016-3799-7 [doi]
AB  - INTRODUCTION: The use of scalp cooling for the prevention of chemotherapy-induced 
      alopecia (CIA) is increasing. Cold caps are placed onto the hair-bearing areas of 
      the scalp for varying time periods before, during, and after cytotoxic 
      chemotherapy. Although not yet reported, improper application procedures could 
      result in adverse events (AEs). At present, there are no evidence-based scalp 
      cooling protocols, and there is no regulatory oversight of their use. OBJECTIVE: 
      To report the occurrence of cold thermal injury (frostbite) on the scalp, 
      following the use of cold caps for the prevention of CIA. MATERIALS AND METHODS: 
      We identified four patients who developed cold thermal injuries on the scalp 
      following the application of cold caps. Medical records were analyzed to retrieve 
      the demographic and clinical characteristics. RESULTS: The cold thermal injuries 
      in our patients were grade 1/2 in severity and improved with topical 
      interventions and interruption of cold cap use, although grade 1 persistent 
      alopecia ensued in 3 patients. The true incidence of such injuries in this 
      setting, however, remains unknown. CONCLUSIONS: Cold thermal injuries are likely 
      infrequent and preventable AEs that may result from improper device application 
      procedures during cold cap use. Although these untoward events are usually mild 
      to moderate in severity, the potential occurrence of long-term sequelae (e.g., 
      permanent alopecia and scarring) or the need to discontinue cold cap use, are not 
      known. Prospective studies are needed to further elucidate the risk and 
      standardize healthcare delivery methods, and to improve 
      patient/supportive/healthcare provider education.
FAU - Belum, Viswanath Reddy
AU  - Belum VR
AD  - Dermatology Service, Memorial Sloan Kettering Cancer Center, 60th Street 
      Outpatient Center, 16 East 60th St., Suite 407, Room 4312, New York, NY, USA.
FAU - de Barros Silva, Giselle
AU  - de Barros Silva G
AD  - Centro Paulista de Oncologia, Sao Paulo, Brazil.
FAU - Laloni, Mariana Tosello
AU  - Laloni MT
AD  - Centro Paulista de Oncologia, Sao Paulo, Brazil.
FAU - Ciccolini, Kathryn
AU  - Ciccolini K
AD  - Dermatology Service, Memorial Sloan Kettering Cancer Center, 60th Street 
      Outpatient Center, 16 East 60th St., Suite 407, Room 4312, New York, NY, USA.
FAU - Goldfarb, Shari B
AU  - Goldfarb SB
AD  - Breast Medicine Service, Memorial Sloan Kettering Cancer Center, New York, NY, 
      USA.
FAU - Norton, Larry
AU  - Norton L
AD  - Breast Medicine Service, Memorial Sloan Kettering Cancer Center, New York, NY, 
      USA.
FAU - Sklarin, Nancy T
AU  - Sklarin NT
AD  - Breast Medicine Service, Memorial Sloan Kettering Cancer Center, New York, NY, 
      USA.
FAU - Lacouture, Mario E
AU  - Lacouture ME
AD  - Dermatology Service, Memorial Sloan Kettering Cancer Center, 60th Street 
      Outpatient Center, 16 East 60th St., Suite 407, Room 4312, New York, NY, USA. 
      lacoutum@mskcc.org.
LA  - eng
GR  - P30 CA008748/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160505
PL  - Netherlands
TA  - Breast Cancer Res Treat
JT  - Breast cancer research and treatment
JID - 8111104
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Alopecia/chemically induced/*prevention & control
MH  - Antineoplastic Agents/*adverse effects/therapeutic use
MH  - Breast Neoplasms/drug therapy
MH  - Female
MH  - Frostbite/*epidemiology/etiology
MH  - Humans
MH  - Hypothermia, Induced/*adverse effects/instrumentation
MH  - Incidence
MH  - Middle Aged
PMC - PMC5612426
MID - NIHMS876113
OTO - NOTNLM
OT  - Chemotherapy-induced alopecia
OT  - Cold caps
OT  - Cryotherapy
OT  - Frostbite
OT  - Scalp hypothermia
OT  - Thermal injury
COIS- The other authors declare that they have no conflicts of interest.
EDAT- 2016/05/06 06:00
MHDA- 2017/11/29 06:00
PMCR- 2017/09/25
CRDT- 2016/05/06 06:00
PHST- 2016/04/12 00:00 [received]
PHST- 2016/04/15 00:00 [accepted]
PHST- 2016/05/06 06:00 [entrez]
PHST- 2016/05/06 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/09/25 00:00 [pmc-release]
AID - 10.1007/s10549-016-3799-7 [pii]
AID - 10.1007/s10549-016-3799-7 [doi]
PST - ppublish
SO  - Breast Cancer Res Treat. 2016 Jun;157(2):395-400. doi: 10.1007/s10549-016-3799-7. 
      Epub 2016 May 5.