PMID- 27149376
OWN - NLM
STAT- MEDLINE
DCOM- 20170711
LR  - 20190213
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 5
DP  - 2016
TI  - Endocrine Disrupting Effects of Triclosan on the Placenta in Pregnant Rats.
PG  - e0154758
LID - 10.1371/journal.pone.0154758 [doi]
LID - e0154758
AB  - Triclosan (TCS) is a broad-spectrum antimicrobial agent that is frequently used 
      in pharmaceuticals and personal care products. Reports have shown that TCS is a 
      potential endocrine disruptor; however, the potential effects of TCS on placental 
      endocrine function are unclear. The aim of this study was to investigate the 
      endocrine disrupting effects of TCS on the placenta in pregnant rats. Pregnant 
      rats from gestational day (GD) 6 to GD 20 were treated with 0, 30, 100, 300 and 
      600 mg/kg/d TCS followed by analysis of various biochemical parameters. Of the 
      seven tissues examined, the greatest bioaccumulation of TCS was observed in the 
      placenta. Reduction of gravid uterine weight and the occurrence of abortion were 
      observed in the 600 mg/kg/d TCS-exposed group. Moreover, hormone detection 
      demonstrated that the serum levels of progesterone (P), estradiol (E2), 
      testosterone (T), human chorionic gonadotropin (hCG) and prolactin (PRL) were 
      decreased in groups exposed to higher doses of TCS. Real-time quantitative 
      reverse transcriptase-polymerase chain reaction (Q-RT-PCR) analysis revealed a 
      significant increase in mRNA levels for placental steroid metabolism enzymes, 
      including UDP-glucuronosyltransferase 1A1 (UGT1A1), estrogen sulfotransferase 1E1 
      (SULT1E1), steroid 5alpha-reductase 1 (SRD5A1) and steroid 5alpha-reductase 2 (SRD5A2). 
      Furthermore, the transcriptional expression levels of progesterone receptor (PR), 
      estrogen receptor (ERalpha) and androgen receptor (AR) were up-regulated. Taken 
      together, these data demonstrated that the placenta was a target tissue of TCS 
      and that TCS induced inhibition of circulating steroid hormone production might 
      be related to the altered expression of hormone metabolism enzyme genes in the 
      placenta. This hormone disruption might subsequently affect fetal development and 
      growth.
FAU - Feng, Yixing
AU  - Feng Y
AD  - Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food 
      Poisoning, Beijing Center for Disease Control and Prevention, Beijing, China.
FAU - Zhang, Pin
AU  - Zhang P
AD  - Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food 
      Poisoning, Beijing Center for Disease Control and Prevention, Beijing, China.
FAU - Zhang, Zhaobin
AU  - Zhang Z
AD  - College of Urban and Environmental Sciences, MOE Laboratory for Earth Surface 
      Processes, Peking University, Beijing, China.
FAU - Shi, Jiachen
AU  - Shi J
AD  - Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food 
      Poisoning, Beijing Center for Disease Control and Prevention, Beijing, China.
FAU - Jiao, Zhihao
AU  - Jiao Z
AD  - Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food 
      Poisoning, Beijing Center for Disease Control and Prevention, Beijing, China.
FAU - Shao, Bing
AU  - Shao B
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, College 
      of Veterinary Medicine, China Agricultural University, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160505
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Hormones)
RN  - 4NM5039Y5X (Triclosan)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Endocrine Disruptors/*pharmacology
MH  - Female
MH  - Gene Expression
MH  - Hormones/blood
MH  - Organ Size/drug effects
MH  - Placenta/*drug effects
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Triclosan/*pharmacology
MH  - Uterus/drug effects
PMC - PMC4858197
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2016/05/07 06:00
MHDA- 2017/07/14 06:00
PMCR- 2016/05/05
CRDT- 2016/05/06 06:00
PHST- 2016/01/13 00:00 [received]
PHST- 2016/04/19 00:00 [accepted]
PHST- 2016/05/06 06:00 [entrez]
PHST- 2016/05/07 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
PHST- 2016/05/05 00:00 [pmc-release]
AID - PONE-D-15-54617 [pii]
AID - 10.1371/journal.pone.0154758 [doi]
PST - epublish
SO  - PLoS One. 2016 May 5;11(5):e0154758. doi: 10.1371/journal.pone.0154758. 
      eCollection 2016.