PMID- 27150004
OWN - NLM
STAT- MEDLINE
DCOM- 20170201
LR  - 20170201
IS  - 1349-3299 (Electronic)
IS  - 1349-2365 (Linking)
VI  - 57
IP  - 3
DP  - 2016 May 25
TI  - Successful Pregnancy and Delivery in a Heart Transplantation Recipient.
PG  - 383-5
LID - 10.1536/ihj.15-414 [doi]
AB  - For 6 years after heart transplantation, a 23-year old female recipient had been 
      treated with immunosuppressants including tacrolimus and mycophenolate mofetil 
      (MMF), without any major rejection or graft dysfunction. She unexpectedly became 
      pregnant for the first time, and we converted MMF to azathioprine (AZA), but she 
      soon experienced a spontaneous abortion. After careful counseling under the 
      continuation of AZA, she became pregnant again 3 months after the abortion. We 
      closely monitored the concentration of immunosuppressive agents, cardiac 
      function, fetal condition, and serological assay including human leukocyte 
      antigen (HLA) sensitization, and she eventually delivered a normal male infant at 
      38 weeks gestation without any complications. AZA was converted to MMF soon after 
      the delivery. There have been no complications in either the patient or infant 
      after the delivery.Because pregnancy itself involves a risk of cardiac graft 
      rejection in the recipient as well as fetal complications, it is important to 
      educate HTx recipients about planned pregnancy and to conduct careful follow-up 
      after pregnancy.
FAU - Nitta, Daisuke
AU  - Nitta D
AD  - Department of Cardiovascular Medicine, Graduate School of Medicine, The 
      University of Tokyo.
FAU - Kinugawa, Koichiro
AU  - Kinugawa K
FAU - Imamura, Teruhiko
AU  - Imamura T
FAU - Endo, Miyoko
AU  - Endo M
FAU - Amiya, Eisuke
AU  - Amiya E
FAU - Hatano, Masaru
AU  - Hatano M
FAU - Takahashi, Yuko
AU  - Takahashi Y
FAU - Iriyama, Takayuki
AU  - Iriyama T
FAU - Kinoshita, Osamu
AU  - Kinoshita O
FAU - Nagamatsu, Takeshi
AU  - Nagamatsu T
FAU - Nawata, Kan
AU  - Nawata K
FAU - Ono, Minoru
AU  - Ono M
FAU - Komuro, Issei
AU  - Komuro I
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160428
PL  - Japan
TA  - Int Heart J
JT  - International heart journal
JID - 101244240
RN  - 0 (Immunosuppressive Agents)
RN  - HU9DX48N0T (Mycophenolic Acid)
RN  - MRK240IY2L (Azathioprine)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Adult
MH  - Azathioprine/*administration & dosage
MH  - Drug Substitution/methods
MH  - Female
MH  - Graft Rejection/*prevention & control
MH  - Graft Survival
MH  - *Heart Transplantation/adverse effects/methods
MH  - Humans
MH  - Immunosuppressive Agents/administration & dosage
MH  - Infant, Newborn
MH  - Male
MH  - Monitoring, Physiologic/methods
MH  - Mycophenolic Acid/*administration & dosage
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Pregnancy, High-Risk/*immunology
MH  - Tacrolimus/*administration & dosage
EDAT- 2016/05/07 06:00
MHDA- 2017/02/02 06:00
CRDT- 2016/05/07 06:00
PHST- 2016/05/07 06:00 [entrez]
PHST- 2016/05/07 06:00 [pubmed]
PHST- 2017/02/02 06:00 [medline]
AID - 10.1536/ihj.15-414 [doi]
PST - ppublish
SO  - Int Heart J. 2016 May 25;57(3):383-5. doi: 10.1536/ihj.15-414. Epub 2016 Apr 28.