PMID- 27150707
OWN - NLM
STAT- MEDLINE
DCOM- 20170512
LR  - 20191210
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Linking)
VI  - 90
DP  - 2016 Sep
TI  - Temporal lobe contribution to perceptual function: A tale of three patient 
      groups.
PG  - 33-45
LID - S0028-3932(16)30150-6 [pii]
LID - 10.1016/j.neuropsychologia.2016.05.002 [doi]
AB  - There has been growing recognition of the contribution of medial and anterior 
      temporal lobe structures to non-mnemonic functions, such as perception. To 
      evaluate the nature of this contribution, we contrast the perceptual performance 
      of three patient groups, all of whom have a perturbation of these temporal lobe 
      structures. Specifically, we compare the profile of patients with focal 
      hippocampal (HC) lesions, those with more extensive lesions to the medial 
      temporal lobe (MTL) that include HC and perirhinal cortex (PrC), and those with 
      congenital prosopagnosia (CP), whose deficit has been attributed to the 
      disconnection of the anterior temporal lobe from more posterior structures. All 
      participants completed a range of'oddity' tasks in which, on each trial, they 
      determined which of four visual stimuli in a display was the'odd-one-out'. There 
      were five stimulus categories including faces, scenes, objects (high and low 
      ambiguity) and squares of different sizes. Comparisons were conducted separately 
      for the HC, MTL and CP groups against their matched control groups and then the 
      group data were compared to each other directly. The group profiles were easily 
      differentiable. Whereas the HC group stood out for its difficulty in 
      discriminating scenes and the CP group stood out for its disproportionate 
      difficulty in discriminating faces with milder effects for scenes and high 
      ambiguity objects, the MTL group evinced a more general discrimination deficit 
      for faces, scenes and high ambiguity objects. The group differences highlight 
      distinct profiles for each of the three groups and distinguish the signature 
      perceptual impairments following more extended temporal lobe alterations. In the 
      recent reconsideration of the role of the hippocampus and neocortex, Moscovitch 
      and colleagues (Moscovitch et al., 2016) note that the medial temporal lobe 
      structures play a role in non-mnemonic functions, such as perception, problem 
      solving, decision-making and language. Here, we address this exact issue, 
      specifically with respect to perception, and we dedicate this paper to Morris 
      Moscovitch in recognition of his profound contribution to science, to his 
      students and to his colleagues.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Behrmann, M
AU  - Behrmann M
AD  - Department of Psychology and Center for the Neural Basis of Cognition, Carnegie 
      Mellon University, Pittsburgh PA 15213-3890, United States. Electronic address: 
      behrmann@cmu.edu.
FAU - Lee, A C H
AU  - Lee AC
AD  - Rotman Research Institute, Toronto, ON, Canada M6A 2E1; Department of Psychology 
      (Scarborough), University of Toronto, Toronto, ON, Canada M1C 1A4.
FAU - Geskin, J Z
AU  - Geskin JZ
AD  - Department of Psychology and Center for the Neural Basis of Cognition, Carnegie 
      Mellon University, Pittsburgh PA 15213-3890, United States.
FAU - Graham, K S
AU  - Graham KS
AD  - Cardiff University Brain Research Imaging Centre and School of Psychology, 
      Cardiff University, Maindy Road, Cardiff CF24 4HQ, UK.
FAU - Barense, M D
AU  - Barense MD
AD  - Rotman Research Institute, Toronto, ON, Canada M6A 2E1; Department of Psychology 
      (St George), University of Toronto, Toronto, ON, Canada M5S 3G3.
LA  - eng
GR  - MOP-115148/CIHR/Canada
GR  - G1002149/Medical Research Council/United Kingdom
GR  - BB/1007091/1/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
DEP - 20160502
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
RN  - Prosopagnosia, hereditary
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Brain Injuries/diagnostic imaging/pathology/*physiopathology
MH  - Case-Control Studies
MH  - Discrimination, Psychological
MH  - Female
MH  - Hippocampus/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Perceptual Disorders/etiology/pathology
MH  - Photic Stimulation
MH  - Prosopagnosia/*congenital/diagnostic imaging/pathology
MH  - Recognition, Psychology
MH  - Temporal Lobe/diagnostic imaging/*physiopathology
MH  - Visual Perception/*physiology
OTO - NOTNLM
OT  - Amnesia
OT  - Congenital prosopagnosia
OT  - Hippocampus
OT  - Medial temporal lobe
OT  - Perception
OT  - Perirhinal cortex
OT  - Visual discrimination
EDAT- 2016/05/07 06:00
MHDA- 2017/05/13 06:00
CRDT- 2016/05/07 06:00
PHST- 2016/01/21 00:00 [received]
PHST- 2016/04/08 00:00 [revised]
PHST- 2016/05/02 00:00 [accepted]
PHST- 2016/05/07 06:00 [entrez]
PHST- 2016/05/07 06:00 [pubmed]
PHST- 2017/05/13 06:00 [medline]
AID - S0028-3932(16)30150-6 [pii]
AID - 10.1016/j.neuropsychologia.2016.05.002 [doi]
PST - ppublish
SO  - Neuropsychologia. 2016 Sep;90:33-45. doi: 10.1016/j.neuropsychologia.2016.05.002. 
      Epub 2016 May 2.