PMID- 27151278
OWN - NLM
STAT- MEDLINE
DCOM- 20170127
LR  - 20170127
IS  - 1432-8798 (Electronic)
IS  - 0304-8608 (Linking)
VI  - 161
IP  - 8
DP  - 2016 Aug
TI  - Pathogenicity comparison between highly pathogenic and NADC30-like porcine 
      reproductive and respiratory syndrome virus.
PG  - 2257-61
LID - 10.1007/s00705-016-2883-y [doi]
AB  - The pathogenicity of HNjz15, an NADC30-like strain of porcine reproductive and 
      respiratory syndrome virus (PRRSV), was investigated and compared to that of a 
      highly pathogenic PRRSV JAX1 strain. Six-week-old pigs infected with each virus 
      showed typical clinical symptoms, including high fever and respiratory disorders. 
      Pigs infected with JXA1 had more-severe clinical manifestations than pigs 
      infected with HNjz15. HNjz15 replicated in vivo with kinetics similar to those of 
      JXA1 but induced a lower level of PRRSV-specific antibody at the beginning of 
      virus infection. Histopathologically, JXA1 infection led to more-severe lung 
      lesions and broader organ tropism than HNjz15 did. Different from what was 
      observed with the previously reported NADC30-like PRRSV JL580 strain, all 
      HNjz15-infected pigs survived until the end of the study. All of these results 
      indicated that NADC30-like PRRSV HNjz15 is virulent to pigs but is less 
      pathogenic than the JXA1 and JL580 PRRSV strains.
FAU - Sun, Zhe
AU  - Sun Z
AD  - National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech 
      District, 471003, Beijing, People's Republic of China.
FAU - Wang, Juan
AU  - Wang J
AD  - National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech 
      District, 471003, Beijing, People's Republic of China.
FAU - Bai, Xiaofei
AU  - Bai X
AD  - National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech 
      District, 471003, Beijing, People's Republic of China.
FAU - Ji, Guobiao
AU  - Ji G
AD  - National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech 
      District, 471003, Beijing, People's Republic of China.
FAU - Yan, He
AU  - Yan H
AD  - National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech 
      District, 471003, Beijing, People's Republic of China.
FAU - Li, Yingying
AU  - Li Y
AD  - National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech 
      District, 471003, Beijing, People's Republic of China.
FAU - Wang, Yuzhou
AU  - Wang Y
AD  - National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech 
      District, 471003, Beijing, People's Republic of China.
FAU - Tan, Feifei
AU  - Tan F
AD  - National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech 
      District, 471003, Beijing, People's Republic of China.
FAU - Xiao, Yan
AU  - Xiao Y
AD  - National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech 
      District, 471003, Beijing, People's Republic of China.
FAU - Li, Xiangdong
AU  - Li X
AD  - National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech 
      District, 471003, Beijing, People's Republic of China. xiaonanzhong@163.com.
FAU - Tian, Kegong
AU  - Tian K
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou, People's Republic of China. tiankg@263.net.
AD  - National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech 
      District, 471003, Beijing, People's Republic of China. tiankg@263.net.
AD  - OIE Porcine Reproductive and Respiratory Syndrome Reference Laboratory, Beijing, 
      People's Republic of China. tiankg@263.net.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160505
PL  - Austria
TA  - Arch Virol
JT  - Archives of virology
JID - 7506870
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Lung/pathology/virology
MH  - Porcine Reproductive and Respiratory Syndrome/blood/pathology/*virology
MH  - Porcine respiratory and reproductive syndrome 
      virus/classification/*pathogenicity/physiology
MH  - Swine
MH  - Virulence
OTO - NOTNLM
OT  - HNjz15
OT  - JXA1
OT  - NADC30-like
OT  - PRRSV
OT  - Pathogenicity
EDAT- 2016/05/07 06:00
MHDA- 2017/01/28 06:00
CRDT- 2016/05/07 06:00
PHST- 2016/02/14 00:00 [received]
PHST- 2016/04/28 00:00 [accepted]
PHST- 2016/05/07 06:00 [entrez]
PHST- 2016/05/07 06:00 [pubmed]
PHST- 2017/01/28 06:00 [medline]
AID - 10.1007/s00705-016-2883-y [pii]
AID - 10.1007/s00705-016-2883-y [doi]
PST - ppublish
SO  - Arch Virol. 2016 Aug;161(8):2257-61. doi: 10.1007/s00705-016-2883-y. Epub 2016 
      May 5.