PMID- 27151376
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20220318
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 May 6
TI  - Type 3 Diabetes: Cross Talk between Differentially Regulated Proteins of Type 2 
      Diabetes Mellitus and Alzheimer's Disease.
PG  - 25589
LID - 10.1038/srep25589 [doi]
LID - 25589
AB  - Type 3 Diabetes (T3D) is a neuroendocrine disorder that represents the 
      progression of Type 2 Diabetes Mellitus (T2DM) to Alzheimer's disease (AD). T3D 
      contributes in the increase of the total load of Alzheimer's patients worldwide. 
      The protein network based strategies were used for the analysis of protein 
      interactions and hypothesis was derived describing the possible routes of 
      communications among proteins. The hypothesis provides the insight on the 
      probable mechanism of the disease progression for T3D. The current study also 
      suggests that insulin degrading enzyme (IDE) could be the major player which 
      holds the capacity to shift T2DM to T3D by altering metabolic pathways like 
      regulation of beta-cell development, negative regulation of PI3K/AKT pathways and 
      amyloid beta degradation.
FAU - Mittal, Khyati
AU  - Mittal K
AD  - Proteomic &Translational Research Lab, Centre for Medical Biotechnology, Amity 
      Institute of Biotechnology, Amity University Uttar Pradesh, Noida 201313, India.
FAU - Mani, Ruchi Jakhmola
AU  - Mani RJ
AD  - Proteomic &Translational Research Lab, Centre for Medical Biotechnology, Amity 
      Institute of Biotechnology, Amity University Uttar Pradesh, Noida 201313, India.
FAU - Katare, Deepshikha Pande
AU  - Katare DP
AD  - Proteomic &Translational Research Lab, Centre for Medical Biotechnology, Amity 
      Institute of Biotechnology, Amity University Uttar Pradesh, Noida 201313, India.
LA  - eng
PT  - Journal Article
DEP - 20160506
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Proteins)
SB  - IM
MH  - Alzheimer Disease/*metabolism
MH  - Databases, Protein
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Humans
MH  - Protein Binding
MH  - Protein Interaction Maps
MH  - Proteins/*metabolism
MH  - Signal Transduction
PMC - PMC4858691
EDAT- 2016/05/07 06:00
MHDA- 2018/03/27 06:00
PMCR- 2016/05/06
CRDT- 2016/05/07 06:00
PHST- 2015/10/22 00:00 [received]
PHST- 2016/04/15 00:00 [accepted]
PHST- 2016/05/07 06:00 [entrez]
PHST- 2016/05/07 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2016/05/06 00:00 [pmc-release]
AID - srep25589 [pii]
AID - 10.1038/srep25589 [doi]
PST - epublish
SO  - Sci Rep. 2016 May 6;6:25589. doi: 10.1038/srep25589.