PMID- 27151685
OWN - NLM
STAT- MEDLINE
DCOM- 20170403
LR  - 20170403
IS  - 2066-8279 (Electronic)
IS  - 1220-0522 (Linking)
VI  - 57
IP  - 1
DP  - 2016
TI  - pH sensitive core-shell magnetic nanoparticles for targeted drug delivery in 
      cancer therapy.
PG  - 23-32
AB  - In the last decade, nanobiotechnology has evolved rapidly with an extensive 
      impact on biomedical area. In order to improve bioavailability and minimize 
      adverse effects, drug delivery systems based on magnetic nanocomposites are under 
      development mainly for cancer imaging and antitumor therapy. In this regard, pH 
      sensitive core-shell magnetic nanoparticles (NPs) with accurate controlled size 
      and shape are synthesized by various modern methods, such as homogeneous 
      precipitation, coprecipitation, microemulsion or polyol approaches, high 
      temperature and hydrothermal reactions, sol-gel reactions, aerosol/vapor 
      processes and sonolysis. Due to their unique combined physico-chemical and 
      biological properties (such as higher dispensability, chemical and thermal 
      stability, biocompatibility), pH responsive core-shell magnetic NPs are widely 
      investigated for controlled release of cytostatic drugs into the tumor site by 
      means of pH change: magnetite@silicon dioxide (Fe3O4@SiO2), Fe3O4@titanium 
      dioxide (TiO2), beta-thiopropionate-polyethylene glycol (PEG)-modified Fe3O4@mSiO2, 
      Fe3O4 NPs core coated with SiO2 with an imidazole group modified PEG-polypeptide 
      (mPEG-poly-L-Asparagine), polyacrylic acid (PAA) and folic acid (FA) coating of 
      the iron oxide NP core, methoxy polyethylene glycol-block-polymethacrylic 
      acid-block-polyglycerol monomethacrylate (MPEG-b-PMAA-b-PGMA) attached by a PGMA 
      block to a Fe3O4 core, PEG-modified polyamidoamine (PAMAM) dendrimer shell with 
      Fe3O4 core and mesoporous silica coated on Fe3O4, mostly coated with an 
      anticancer drug. This review paper highlights the modern research directions 
      currently employed to demonstrate the utility of the pH responsive core-shell 
      magnetic NPs in diagnosis and treatment of oncological diseases.
FAU - Lungu, Iulia Ioana
AU  - Lungu II
AD  - Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, 
      Faculty of Applied Chemistry and Materials Science, University Politehnica of 
      Bucharest, Romania; radulescu_marius@yahoo.com.
FAU - Radulescu, Marius
AU  - Radulescu M
FAU - Mogosanu, George Dan
AU  - Mogosanu GD
FAU - Grumezescu, Alexandru Mihai
AU  - Grumezescu AM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Romania
TA  - Rom J Morphol Embryol
JT  - Romanian journal of morphology and embryology = Revue roumaine de morphologie et 
      embryologie
JID - 9112454
RN  - 0 (Drug Carriers)
RN  - 0 (Magnetite Nanoparticles)
SB  - IM
MH  - Animals
MH  - Drug Carriers/chemistry
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Magnetite Nanoparticles/*chemistry
MH  - Neoplasms/*drug therapy
EDAT- 2016/05/07 06:00
MHDA- 2017/04/04 06:00
CRDT- 2016/05/07 06:00
PHST- 2016/05/07 06:00 [entrez]
PHST- 2016/05/07 06:00 [pubmed]
PHST- 2017/04/04 06:00 [medline]
AID - 570116023032 [pii]
PST - ppublish
SO  - Rom J Morphol Embryol. 2016;57(1):23-32.