PMID- 27151693
OWN - NLM
STAT- MEDLINE
DCOM- 20170403
LR  - 20170403
IS  - 2066-8279 (Electronic)
IS  - 1220-0522 (Linking)
VI  - 57
IP  - 1
DP  - 2016
TI  - Histopathological changes induced by selective inactivation of menin on the 
      thyroid gland in RET/PTC3 and E7 transgenic mice. A study of 77 cases.
PG  - 91-8
AB  - Multiple Endocrine Neoplasia Type 1 (MEN1) does not involve the thyroid gland, 
      but animal studies have shown that mice with inactivation of menin could develop 
      thyroid pathologies. The objective was to evaluate if the selective inactivation 
      of menin in murine thyroid glands expressing RET/PTC3 and E7 oncogenes, might 
      induce an increased index of proliferation and a more rapid development of 
      thyroid hyperplasia and/or tumors. The thyroid glands of 77 mice aged 4-18 months 
      (31 expressing the E7 oncogene and 25 the RET/PTC3 oncogene) were analyzed for 
      histological changes and Ki67 proliferation index. Fifty-two mice had selective 
      inactivation of menin in the thyroid gland (16 mice with RET/PTC3 oncogene and 19 
      mice with E7 oncogene). As compared to wild type, mice with inactivation of menin 
      presented an increased Ki67 proliferation index. Mice presenting the E7 oncogene 
      showed larger thyroid glands with a pattern of diffuse hyperplasia. Mice 
      expressing the RET/PTC3 oncogene presented larger thyroid glands compared to the 
      wild type mice but smaller compared to E7 mice. The lesions in the RET/PTC3 group 
      were "proliferative papillary cystic changes" (60%), "cribriform" (16%), "solid" 
      (8%) and a combination of these patterns in the rest of the thyroid glands. The 
      inactivation of menin in the thyroid gland of young mice does not seem to change 
      the histological pattern, but it influences the proliferation of follicular 
      cells. Further molecular studies especially in aged mice are needed to better 
      understand the correlation between certain oncogenes and the inactive status of 
      menin.
FAU - Capraru, Oana Maria
AU  - Capraru OM
AD  - Department of Histology, University of Medicine and Pharmacy of Tirgu Mures, 
      Romania; prorector_int@umftgm.ro.
FAU - Berger, Nicole
AU  - Berger N
FAU - Gadot, Nicolas
AU  - Gadot N
FAU - Decaussin-Petrucci, Myriam
AU  - Decaussin-Petrucci M
FAU - Zhang, Chang
AU  - Zhang C
FAU - Borda, Angela
AU  - Borda A
FAU - Szilagyi, Tibor
AU  - Szilagyi T
FAU - Borson-Chazot, Francoise
AU  - Borson-Chazot F
FAU - Selmi-Ruby, Samia
AU  - Selmi-Ruby S
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Rom J Morphol Embryol
JT  - Romanian journal of morphology and embryology = Revue roumaine de morphologie et 
      embryologie
JID - 9112454
RN  - 0 (Men1 protein, mouse)
RN  - 0 (Papillomavirus E7 Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (oncogene protein E7, Human papillomavirus type 16)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-ret)
SB  - IM
MH  - Animals
MH  - Cell Proliferation
MH  - Hyperplasia
MH  - Mice, Transgenic
MH  - *Oncogenes
MH  - Papillomavirus E7 Proteins/*metabolism
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Proto-Oncogene Proteins c-ret/*metabolism
MH  - Thyroid Gland/metabolism/*pathology
EDAT- 2016/05/07 06:00
MHDA- 2017/04/04 06:00
CRDT- 2016/05/07 06:00
PHST- 2016/05/07 06:00 [entrez]
PHST- 2016/05/07 06:00 [pubmed]
PHST- 2017/04/04 06:00 [medline]
AID - 570116091098 [pii]
PST - ppublish
SO  - Rom J Morphol Embryol. 2016;57(1):91-8.