PMID- 27152737
OWN - NLM
STAT- MEDLINE
DCOM- 20180129
LR  - 20180129
IS  - 1613-6829 (Electronic)
IS  - 1613-6810 (Linking)
VI  - 12
IP  - 25
DP  - 2016 Jul
TI  - Advances in Peptide Functionalization on Mesoporous Silica Nanoparticles for 
      Controlled Drug Release.
PG  - 3344-59
LID - 10.1002/smll.201600325 [doi]
AB  - During the last decade, using versatile, promising, and fascinating mesoporous 
      silica nanoparticles (MSNs) as site-specific and stimuli-responsive drug delivery 
      systems (DDSs) has received concentrated research interest. As one of the most 
      attractive surface modification units, peptides have inherent bioactivity, 
      biodegradability and biocompatibility. Recent progresses in the utilization of 
      versatile peptides for surface functionalization of MSNs to achieve cell-specific 
      targeting, fluorescence imaging, and intracellular diagnosis and treatment of 
      tumors are summarized in this review. The various functional peptides decorated 
      on the MSNs are introduced and classified into three types, including targeting 
      peptides, stimuli-responsive peptides and multifunctional chimeric peptides. The 
      limitations and challenges of peptide modified MSNs and their potential 
      applications are further discussed.
CI  - (c) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Hu, Jing-Jing
AU  - Hu JJ
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education, Institute for 
      Advanced Studies (IAS), Department of Chemistry, Wuhan University, Wuhan, 430072, 
      P. R. China.
FAU - Xiao, Dong
AU  - Xiao D
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education, Institute for 
      Advanced Studies (IAS), Department of Chemistry, Wuhan University, Wuhan, 430072, 
      P. R. China.
FAU - Zhang, Xian-Zheng
AU  - Zhang XZ
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education, Institute for 
      Advanced Studies (IAS), Department of Chemistry, Wuhan University, Wuhan, 430072, 
      P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20160506
PL  - Germany
TA  - Small
JT  - Small (Weinheim an der Bergstrasse, Germany)
JID - 101235338
RN  - 0 (Biocompatible Materials)
RN  - 0 (Peptides)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Biocompatible Materials/chemistry
MH  - Drug Delivery Systems/methods
MH  - Nanoparticles/*chemistry
MH  - Peptides/chemistry
MH  - Porosity
MH  - Silicon Dioxide/*chemistry
OTO - NOTNLM
OT  - drug delivery systems
OT  - peptides
OT  - silica nanoparticles
OT  - stimuli responsive
OT  - targets
EDAT- 2016/05/07 06:00
MHDA- 2018/01/30 06:00
CRDT- 2016/05/07 06:00
PHST- 2016/01/30 00:00 [received]
PHST- 2016/03/22 00:00 [revised]
PHST- 2016/05/07 06:00 [entrez]
PHST- 2016/05/07 06:00 [pubmed]
PHST- 2018/01/30 06:00 [medline]
AID - 10.1002/smll.201600325 [doi]
PST - ppublish
SO  - Small. 2016 Jul;12(25):3344-59. doi: 10.1002/smll.201600325. Epub 2016 May 6.