PMID- 27153935
OWN - NLM
STAT- MEDLINE
DCOM- 20170522
LR  - 20221207
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 43
IP  - 11
DP  - 2016 Nov
TI  - Variation at HLA-DPB1 is associated with dermatomyositis in Chinese population.
PG  - 1307-1313
LID - 10.1111/1346-8138.13397 [doi]
AB  - Dermatomyositis (DM) is a polygenic disorder characterized by inflammation of 
      skeletal muscle and skin. To date, the exact etiopathogenesis of DM remains 
      elusive. To explore the genetic basis of DM, we conducted genome-wide genotyping 
      analysis of 127 patients and 1566 healthy controls by Illumina Human 
      OmniZhongHua-8 BeadChips in the Chinese Han population. We investigated whether 
      the three SNP (rs7750458, rs9501251 and rs9500928) at 6p21.32 in the HLA-DPB1 
      gene were significantly associated with DM (P < 5 x 10(-8) ) and identified two 
      susceptibility loci at 7q34 (PIP, rs9986765, P = 7.45 x 10(-7) , odds ratio [OR] 
      = 2.71) and 10q24.2 (CPN1, rs3750716, P = 9.04 x 10(-7) , OR = 4.39) with 
      suggestive evidence. We imputed 6674 classical human leukocyte antigen (HLA) 
      alleles, amino acids and SNP from the discovery dataset, and stepwise analysis 
      revealed that HLA-DPB1*17 in class II HLA genes were significantly associated 
      with DM susceptibility. This study represents the first genome-wide association 
      study (GWAS) of DM in the Chinese Han population. For the first time, HLA-DPB1 
      was found to be associated with DM in this population. Moreover, we identified 
      two novel suggestive susceptibility loci (PIP and CPN1) and confirmed four 
      previously reported genes (DMB, DQA1, DQB1 and DRB1) having potential 
      associations with DM in the Chinese Han population. Our GWAS results in this 
      population should provide important information regarding the genetic 
      etiopathogenesis of DM and facilitate the development of new therapies for the 
      treatment of DM and the prevention of DM progression.
CI  - (c) 2016 Japanese Dermatological Association.
FAU - Zhang, Chang-E
AU  - Zhang CE
AD  - Institute of Dermatology, Department of Dermatology and Venerology, No. 1 
      Hospital, Anhui Medical University, Hefei, China.
AD  - Department of Dermatology, Zhengzhou Children's Hospital, Henan, China.
AD  - Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical 
      University, Hefei, China.
AD  - State Key Lab Incubation of Dermatology, Ministry of Science and Technology, 
      Hefei, China.
FAU - Li, Yang
AU  - Li Y
AD  - Institute of Dermatology, Department of Dermatology and Venerology, No. 1 
      Hospital, Anhui Medical University, Hefei, China.
AD  - Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical 
      University, Hefei, China.
AD  - State Key Lab Incubation of Dermatology, Ministry of Science and Technology, 
      Hefei, China.
FAU - Wang, Zai-Xing
AU  - Wang ZX
AD  - Institute of Dermatology, Department of Dermatology and Venerology, No. 1 
      Hospital, Anhui Medical University, Hefei, China.
AD  - Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical 
      University, Hefei, China.
AD  - State Key Lab Incubation of Dermatology, Ministry of Science and Technology, 
      Hefei, China.
FAU - Gao, Jin-Ping
AU  - Gao JP
AD  - Institute of Dermatology, Department of Dermatology and Venerology, No. 1 
      Hospital, Anhui Medical University, Hefei, China.
AD  - Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical 
      University, Hefei, China.
AD  - State Key Lab Incubation of Dermatology, Ministry of Science and Technology, 
      Hefei, China.
FAU - Zhang, Xiao-Guang
AU  - Zhang XG
AD  - Institute of Dermatology, Department of Dermatology and Venerology, No. 1 
      Hospital, Anhui Medical University, Hefei, China.
AD  - Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical 
      University, Hefei, China.
AD  - State Key Lab Incubation of Dermatology, Ministry of Science and Technology, 
      Hefei, China.
FAU - Zuo, Xian-Bo
AU  - Zuo XB
AD  - Institute of Dermatology, Department of Dermatology and Venerology, No. 1 
      Hospital, Anhui Medical University, Hefei, China.
AD  - Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical 
      University, Hefei, China.
AD  - State Key Lab Incubation of Dermatology, Ministry of Science and Technology, 
      Hefei, China.
FAU - Sheng, Yu-Jun
AU  - Sheng YJ
AD  - Institute of Dermatology, Department of Dermatology and Venerology, No. 1 
      Hospital, Anhui Medical University, Hefei, China.
AD  - Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical 
      University, Hefei, China.
AD  - State Key Lab Incubation of Dermatology, Ministry of Science and Technology, 
      Hefei, China.
FAU - Chen, Gang
AU  - Chen G
AD  - Institute of Dermatology, Department of Dermatology and Venerology, No. 1 
      Hospital, Anhui Medical University, Hefei, China.
AD  - Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical 
      University, Hefei, China.
AD  - State Key Lab Incubation of Dermatology, Ministry of Science and Technology, 
      Hefei, China.
FAU - Sun, Liang-Dan
AU  - Sun LD
AD  - Institute of Dermatology, Department of Dermatology and Venerology, No. 1 
      Hospital, Anhui Medical University, Hefei, China.
AD  - Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical 
      University, Hefei, China.
AD  - State Key Lab Incubation of Dermatology, Ministry of Science and Technology, 
      Hefei, China.
FAU - Zhang, Xue-Jun
AU  - Zhang XJ
AD  - Institute of Dermatology, Department of Dermatology and Venerology, No. 1 
      Hospital, Anhui Medical University, Hefei, China.
AD  - Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical 
      University, Hefei, China.
AD  - State Key Lab Incubation of Dermatology, Ministry of Science and Technology, 
      Hefei, China.
AD  - Department of Dermatology, No. 2 Hospital, Anhui Medical University, Hefei, 
      China.
AD  - Department of Dermatology, Institutes of Dermatology, Huashan Hospital, Fudan 
      University, Shanghai, China.
FAU - Xu, Jin-Hua
AU  - Xu JH
AD  - State Key Lab Incubation of Dermatology, Ministry of Science and Technology, 
      Hefei, China. xjhhsyy@163.com.
AD  - Department of Dermatology, Institutes of Dermatology, Huashan Hospital, Fudan 
      University, Shanghai, China. xjhhsyy@163.com.
FAU - Yang, Sen
AU  - Yang S
AD  - Institute of Dermatology, Department of Dermatology and Venerology, No. 1 
      Hospital, Anhui Medical University, Hefei, China. yangsen@medmail.com.cn.
AD  - Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical 
      University, Hefei, China. yangsen@medmail.com.cn.
AD  - State Key Lab Incubation of Dermatology, Ministry of Science and Technology, 
      Hefei, China. yangsen@medmail.com.cn.
AD  - Department of Dermatology, No. 2 Hospital, Anhui Medical University, Hefei, 
      China. yangsen@medmail.com.cn.
LA  - eng
SI  - GENBANK/rs7750458
SI  - GENBANK/rs9501251
SI  - GENBANK/rs9500928
SI  - GENBANK/rs9986765
SI  - GENBANK/rs3750716
SI  - GENBANK/rs7574865
SI  - GENBANK/rs1518364
SI  - GENBANK/rs2736340
SI  - GENBANK/rs951005
SI  - GENBANK/rs76475517
SI  - GENBANK/rs3823342
SI  - GENBANK/rs2571382
SI  - GENBANK/rs1053726
SI  - GENBANK/rs12196740
SI  - GENBANK/rs2596501
SI  - GENBANK/rs2308557
SI  - GENBANK/rs1063478
SI  - GENBANK/rs1050391
SI  - GENBANK/rs17617515
SI  - GENBANK/rs12206426
SI  - GENBANK/rs6934645
SI  - GENBANK/rs12206377
SI  - GENBANK/rs9272219
SI  - GENBANK/rs9272783
SI  - GENBANK/rs9272744
SI  - GENBANK/rs2647025
SI  - GENBANK/rs9273448
SI  - GENBANK/rs32627833
SI  - GENBANK/rs35445101
SI  - GENBANK/rs9269693
SI  - GENBANK/rs3830135
SI  - GENBANK/rs2492358
SI  - GENBANK/rs16868943
SI  - GENBANK/rs760902
SI  - GENBANK/rs430620
SI  - GENBANK/rs3918154
SI  - GENBANK/rs7905
SI  - GENBANK/rs987870
SI  - GENBANK/rs2071354
SI  - GENBANK/rs2772372
SI  - GENBANK/rs2516049
SI  - GENBANK/rs477515
PT  - Journal Article
DEP - 20160506
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - China
MH  - Dermatomyositis/*immunology
MH  - Female
MH  - HLA-DP beta-Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - HLA-DPB1
OT  - Chinese Han population
OT  - dermatomyositis
OT  - genome-wide association study
OT  - variation
EDAT- 2016/10/28 06:00
MHDA- 2017/05/23 06:00
CRDT- 2016/05/08 06:00
PHST- 2015/12/28 00:00 [received]
PHST- 2016/02/27 00:00 [accepted]
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2017/05/23 06:00 [medline]
PHST- 2016/05/08 06:00 [entrez]
AID - 10.1111/1346-8138.13397 [doi]
PST - ppublish
SO  - J Dermatol. 2016 Nov;43(11):1307-1313. doi: 10.1111/1346-8138.13397. Epub 2016 
      May 6.