PMID- 27155069 OWN - NLM STAT- MEDLINE DCOM- 20171207 LR - 20191008 IS - 1573-2517 (Electronic) IS - 0165-0327 (Print) IS - 0165-0327 (Linking) VI - 200 DP - 2016 Aug TI - Brain structural anomalies in borderline and avoidant personality disorder patients and their associations with disorder-specific symptoms. PG - 266-74 LID - S0165-0327(15)31492-0 [pii] LID - 10.1016/j.jad.2016.04.053 [doi] AB - BACKGROUND: Borderline personality disorder (BPD) and avoidant personality disorder (AvPD) are characterized by hyper-reactivity to negatively-perceived interpersonal cues, yet they differ in degree of affective instability. Recent work has begun to elucidate the neural (structural and functional) and cognitive-behavioral underpinnings of BPD, although some initial studies of brain structure have reached divergent conclusions. AvPD, however, has been almost unexamined in the cognitive neuroscience literature. METHODS: In the present study we investigated group differences among 29 BPD patients, 27 AvPD patients, and 29 healthy controls (HC) in structural brain volumes using voxel-based morphometry (VBM) in five anatomically-defined regions of interest: amygdala, hippocampus, medial prefrontal cortex (MPFC), dorsolateral prefrontal cortex (DLPFC), and anterior cingulate cortex (ACC). We also examined the relationship between individual differences in brain structure and self-reported anxiety and affective instability in each group. RESULTS: We observed reductions in MPFC and ACC volume in BPD relative to HC, with no significant difference among patient groups. No group differences in amygdala volume were found. However, BPD and AvPD patients each showed a positive relationship between right amygdala volume and state-related anxiety. By contrast, in HC there was an inverse relationship between MPFC volume and state and trait-related anxiety as well as between bilateral DLPFC volume and affective instability. LIMITATIONS: Current sample sizes did not permit examination of gender effects upon structure-symptom correlations. CONCLUSIONS: These results shed light on potentially protective, or compensatory, aspects of brain structure in these populations-namely, relatively reduced amygdala volume or relatively enhanced MPFC and DLPFC volume. CI - Published by Elsevier B.V. FAU - Denny, Bryan T AU - Denny BT AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Fan, Jin AU - Fan J AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychology, Queens College, City University of New York, New York, NY 11367, USA. FAU - Liu, Xun AU - Liu X AD - Institute of Psychology, Chinese Academy of Sciences, Beijing, China. FAU - Guerreri, Stephanie AU - Guerreri S AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Mayson, Sarah Jo AU - Mayson SJ AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Rimsky, Liza AU - Rimsky L AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - McMaster, Antonia AU - McMaster A AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Alexander, Heather AU - Alexander H AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - New, Antonia S AU - New AS AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; James J Peters VA Medical Center, Bronx, NY 10468, USA. FAU - Goodman, Marianne AU - Goodman M AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; James J Peters VA Medical Center, Bronx, NY 10468, USA. FAU - Perez-Rodriguez, Mercedes AU - Perez-Rodriguez M AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Siever, Larry J AU - Siever LJ AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; James J Peters VA Medical Center, Bronx, NY 10468, USA. FAU - Koenigsberg, Harold W AU - Koenigsberg HW AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; James J Peters VA Medical Center, Bronx, NY 10468, USA. Electronic address: HWarrenK@nyc.rr.com. LA - eng GR - R01 MH077813/MH/NIMH NIH HHS/United States GR - UL1 TR000067/TR/NCATS NIH HHS/United States GR - F32 MH105119/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20160427 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM MH - Adult MH - Affect/physiology MH - Anxiety/diagnostic imaging/psychology MH - Borderline Personality Disorder/*diagnostic imaging/psychology MH - Brain/*diagnostic imaging MH - Brain Mapping/methods MH - Female MH - Gyrus Cinguli/*diagnostic imaging MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Organ Size/physiology MH - Personality Disorders/*diagnostic imaging/psychology MH - Social Perception MH - Young Adult PMC - PMC5841761 MID - NIHMS784340 OTO - NOTNLM OT - *Affective instability OT - *Anxiety OT - *Avoidant personality disorder OT - *Borderline personality disorder OT - *Voxel-based morphometry EDAT- 2016/05/08 06:00 MHDA- 2017/12/08 06:00 PMCR- 2018/03/07 CRDT- 2016/05/08 06:00 PHST- 2015/12/31 00:00 [received] PHST- 2016/03/22 00:00 [revised] PHST- 2016/04/23 00:00 [accepted] PHST- 2016/05/08 06:00 [entrez] PHST- 2016/05/08 06:00 [pubmed] PHST- 2017/12/08 06:00 [medline] PHST- 2018/03/07 00:00 [pmc-release] AID - S0165-0327(15)31492-0 [pii] AID - 10.1016/j.jad.2016.04.053 [doi] PST - ppublish SO - J Affect Disord. 2016 Aug;200:266-74. doi: 10.1016/j.jad.2016.04.053. Epub 2016 Apr 27.