PMID- 27155073
OWN - NLM
STAT- MEDLINE
DCOM- 20170808
LR  - 20170817
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 216
DP  - 2016 Aug 1
TI  - Silent myocardial ischemia in asymptomatic patients with type 2 diabetes mellitus 
      without previous histories of cardiovascular disease.
PG  - 151-5
LID - S0167-5273(16)30683-0 [pii]
LID - 10.1016/j.ijcard.2016.04.008 [doi]
AB  - BACKGROUND: The number of patients with type 2 diabetes mellitus (T2DM) continues 
      to increase all over the world. Cardiovascular disease (CVD), especially coronary 
      artery disease (CAD), is a major cause of the morbidity and mortality in patients 
      with T2DM. The prognosis of patients with silent myocardial ischemia (SMI) is 
      worse than that in those without. METHODS AND RESULTS: Thus, to assess how many 
      patients with SMI existed among those patients, CVD screening tests were 
      performed in 128 asymptomatic patients with T2DM without previous histories of 
      CVD. SMI could be detected in 24 patients (19%) by exercise stress tests and/or 
      the coronary fractional flow reserve. Their 12-lead electrocardiogram and cardiac 
      ultrasonography were both normal. Compared to those without SMI, those with had a 
      statistically significant longer history of T2DM (17+/-1 versus 11+/-1years, 
      p=0.006), and the co-existence of a family history of CVD (42% versus 21%, 
      p=0.037). Furthermore, these factors were demonstrated as independent risk 
      factors of SMI by a multivariate analysis (Odds ratio 1.060 and 4.000, 
      respectively), and in accordance with the disease duration of T2DM, the 
      prevalence of patients with SMI has been increasing (p=0.019). CONCLUSIONS: 
      Physicians should be aware of these conditions when examining patients with T2DM, 
      especially with a family history of CVD and/or long disease duration (>11years) 
      of T2DM, even though they have no symptoms, previous histories of CVDs, and/or 
      abnormal findings on the 12-lead electrocardiogram and cardiac ultrasonography. 
      This may be an effective, safe, and attractive diagnostic strategy for those 
      asymptomatic patients with T2DM.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Kawano, Yuki
AU  - Kawano Y
AD  - Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
FAU - Takemoto, Masao
AU  - Takemoto M
AD  - Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan. 
      Electronic address: matakemo@suikokai.or.jp.
FAU - Mito, Takahiro
AU  - Mito T
AD  - Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
FAU - Morisaki, Hiroko
AU  - Morisaki H
AD  - Diabetes and Endocrine Center, Munakata Suikokai General Hospital, Fukutsu, 
      Japan.
FAU - Tanaka, Atsushi
AU  - Tanaka A
AD  - Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
FAU - Sakaki, Yuka
AU  - Sakaki Y
AD  - Diabetes and Endocrine Center, Munakata Suikokai General Hospital, Fukutsu, 
      Japan.
FAU - Matsuo, Atsutoshi
AU  - Matsuo A
AD  - Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
FAU - Abe, Kentaro
AU  - Abe K
AD  - Diabetes and Endocrine Center, Munakata Suikokai General Hospital, Fukutsu, 
      Japan.
FAU - Hida, Satoru
AU  - Hida S
AD  - Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
FAU - Mukae, Kumiko
AU  - Mukae K
AD  - Diabetes and Endocrine Center, Munakata Suikokai General Hospital, Fukutsu, 
      Japan.
FAU - Okazaki, Teiji
AU  - Okazaki T
AD  - Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
FAU - Tayama, Kei-Ichiro
AU  - Tayama K
AD  - Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
FAU - Inoguchi, Toyoshi
AU  - Inoguchi T
AD  - Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, 
      Japan.
FAU - Yoshitake, Kiyonobu
AU  - Yoshitake K
AD  - Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
FAU - Kosuga, Ken-Ichi
AU  - Kosuga K
AD  - Cardiovascular Center, Munakata Suikokai General Hospital, Fukutsu, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160411
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Electrocardiography
MH  - Exercise Test
MH  - Female
MH  - Fractional Flow Reserve, Myocardial
MH  - Humans
MH  - Male
MH  - Myocardial Ischemia/*diagnosis/*epidemiology
MH  - Odds Ratio
MH  - Prevalence
MH  - Prognosis
MH  - Risk Factors
OTO - NOTNLM
OT  - Asymptomatic
OT  - Diabetes mellitus
OT  - Disease duration
OT  - Family history
OT  - Silent myocardial ischemia
EDAT- 2016/05/08 06:00
MHDA- 2017/08/09 06:00
CRDT- 2016/05/08 06:00
PHST- 2016/03/01 00:00 [received]
PHST- 2016/04/02 00:00 [accepted]
PHST- 2016/05/08 06:00 [entrez]
PHST- 2016/05/08 06:00 [pubmed]
PHST- 2017/08/09 06:00 [medline]
AID - S0167-5273(16)30683-0 [pii]
AID - 10.1016/j.ijcard.2016.04.008 [doi]
PST - ppublish
SO  - Int J Cardiol. 2016 Aug 1;216:151-5. doi: 10.1016/j.ijcard.2016.04.008. Epub 2016 
      Apr 11.