PMID- 27156319
OWN - NLM
STAT- MEDLINE
DCOM- 20160602
LR  - 20191113
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 62
IP  - 3
DP  - 2016
TI  - B-type Natriuretic Peptide and RISK-PCI Score in the Risk Assessment in Patients 
      with STEMI Treated by Primary Percutaneous Coronary Intervention.
PG  - 317-25
AB  - BACKGROUND: RISK-PCI score is a novel score for risk stratification of patients 
      with ST elevation myocardial infarction (STEMI) treated by primary percutaneous 
      coronary intervention (pPCI). The aim of this study was to evaluate the role of 
      B-type natriuretic peptide (BNP) and the RISK-PCI score for early risk assessment 
      in patients with STEMI treated by pPCI. METHODS: In 120 patients with STEMI 
      treated by pPCI, BNP was measured on admission before pPCI. The primary end point 
      was 30-day mortality. RESULTS: The ROC curve analysis revealed that the most 
      powerful predictive factors of 30-day mortality were the plasma level of BNP >/= 
      206.6 pg/mL with the sensitivity of 75% and specificity of 87.5% and the RISK-PCI 
      score >/= 5.25 with the sensitivity of 75% and specificity of 85.7%. Thirty-day 
      mortality was 6.7%. After multivariate adjustment, admission BNP (>/= 206.6 pg/mL) 
      (OR 2.952, 95% CI 1.072 - 8.133, p = 0.036) and the RISK-PCI score (>/= 5.25) (OR 
      2.284, 95% CI 1.140-4.578, p = 0.020) were independent predictors of 30-day 
      mortality. The area under the ROC curve using the RISK-PCI score and BNP to 
      detect mortality was 0.828 (p = 0.002) and 0.903 (p < 0.001), respectively. 
      Addition of BNP to RISK-PCI score increased the area under the ROC to 0.949 (p < 
      0.001), but this increase measured by the c-statistic was not significant (p = 
      0.107). Furthermore, the significant improvement in risk reclassification (p < 
      0.001) and the integrated discrimination index (p = 0.042) were observed with the 
      addition of BNP to RISK-PCI score for 30-day mortality. CONCLUSIONS: BNP on 
      admission and the RISK-PCI score were the independent predictors of 30-day 
      mortality in patients with the STEMI treated by pPCI. BNP in combination with the 
      RISK-PCI score showed the way to more accurate risk assessment in patients with 
      STEMI treated by pPCI.
FAU - Asanin, Milika
AU  - Asanin M
FAU - Mrdovic, Igor
AU  - Mrdovic I
FAU - Savic, Lidija
AU  - Savic L
FAU - Matic, Dragan
AU  - Matic D
FAU - Krljanac, Gordana
AU  - Krljanac G
FAU - Vukcevic, Vladan
AU  - Vukcevic V
FAU - Orlic, Dejan
AU  - Orlic D
FAU - Stankovic, Goran
AU  - Stankovic G
FAU - Marinkovic, Jelena
AU  - Marinkovic J
FAU - Stankovic, Sanja
AU  - Stankovic S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*mortality/therapy
MH  - Natriuretic Peptide, Brain/*blood
MH  - *Percutaneous Coronary Intervention
MH  - ROC Curve
MH  - *Risk Assessment
EDAT- 2016/05/10 06:00
MHDA- 2016/06/03 06:00
CRDT- 2016/05/10 06:00
PHST- 2016/05/10 06:00 [entrez]
PHST- 2016/05/10 06:00 [pubmed]
PHST- 2016/06/03 06:00 [medline]
AID - 10.7754/clin.lab.2015.150523 [doi]
PST - ppublish
SO  - Clin Lab. 2016;62(3):317-25. doi: 10.7754/clin.lab.2015.150523.