PMID- 27158359
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160509
LR  - 20201001
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 8
IP  - 2
DP  - 2016
TI  - ODAM is a predictor for biomedical recurrence and inhibits the migration and 
      invasion of prostate cancer.
PG  - 670-9
AB  - Odontogenic ameloblast associated protein (ODAM) is a protein contributed to cell 
      adhesion and has been shown to express in normal prostate tissue, but the 
      expression and significance of ODAM in prostate cancer remain unknown. In this 
      study, we detected the protein expressions of ODAM in 88 prostate cancer tissues 
      with immunohistochemical staining, and found that 53 cases (60.2%) was high 
      expression of ODAM, which was shown in the cytoplasm and paranuclear regions. 
      Furthermore, low expression of ODAM was significantly correlated with lymph node 
      metastasis, preoperative PSA and Gleason score, but not with mean age, follow-up 
      duration, PSM rate and distribution of pathological T stage. Additionally, our 
      results of multivariate analysis showed that low ODAM expression was an 
      independent predictor of biomedical recurrence, while the positive lymph node 
      metastasis, Gleason score, and preoperative PSA were not the independent risks 
      for biomedical recurrence. Overexpression of ODAM did not inhibit the growth of 
      prostate cancer cells PC3, but significant suppressed their invasion and 
      migration with decrease of the protein levels of MMP-2. These results suggest 
      that ODAM is a predictor for biomedical recurrence and inhibits the migration and 
      invasion of prostate cancer.
FAU - Luo, Yun
AU  - Luo Y
AD  - Department of Urology, The 3rd Affiliated Hospital of Sun Yat-Sen University 
      Guangzhou, Guangdong, China.
FAU - Wu, Jie-Ying
AU  - Wu JY
AD  - Department of Urology, The 3rd Affiliated Hospital of Sun Yat-Sen University 
      Guangzhou, Guangdong, China.
FAU - Hou, Guo-Liang
AU  - Hou GL
AD  - Department of Urology, Foshan First Municipal People's Hospital Foshan 528000, 
      China.
FAU - Lu, Min-Hua
AU  - Lu MH
AD  - Department of Urology, The 3rd Affiliated Hospital of Sun Yat-Sen University 
      Guangzhou, Guangdong, China.
FAU - Shi, Zhi
AU  - Shi Z
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan University 
      Guangzhou, Guangdong, China.
FAU - Di, Jin-Ming
AU  - Di JM
AD  - Department of Urology, The 3rd Affiliated Hospital of Sun Yat-Sen University 
      Guangzhou, Guangdong, China.
LA  - eng
PT  - Journal Article
DEP - 20160215
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC4846916
OTO - NOTNLM
OT  - ODAM
OT  - invasion
OT  - migration
OT  - prostate cancer
EDAT- 2016/05/10 06:00
MHDA- 2016/05/10 06:01
PMCR- 2016/02/15
CRDT- 2016/05/10 06:00
PHST- 2015/12/07 00:00 [received]
PHST- 2016/01/04 00:00 [accepted]
PHST- 2016/05/10 06:00 [entrez]
PHST- 2016/05/10 06:00 [pubmed]
PHST- 2016/05/10 06:01 [medline]
PHST- 2016/02/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2016 Feb 15;8(2):670-9. eCollection 2016.