PMID- 27158380
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160509
LR  - 20220318
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 8
IP  - 2
DP  - 2016
TI  - Circular RNA: a novel biomarker for progressive laryngeal cancer.
PG  - 932-9
AB  - Circular RNAs (circRNAs), a class of endogenous RNAs, are characterized by 
      covalently closed continuous loop without 5' to 3' polarity and polyadenylated 
      tail. Recent studies indicated that circRNAs might play an important role in 
      cancer. However, the function of circRNA in laryngeal squamous cell cancer 
      tissues (LSCC) is still unknown. In this study, we investigated the expression of 
      circRNAs in 4 paired LSCC tissues and adjacent non-tumor tissues by microarray 
      analysis. Results showed significant upregulation (n = 302) of or downregulation 
      (n = 396) of 698 circRNAs in LSCC tissues. We further detected hsa_circRNA_100855 
      as the most upregulated circRNA and hsa_circRNA_104912 as the most downregulated 
      circRNA using qRT-PCR methods. Results showed that hsa_circRNA_100855 level was 
      significantly higher in LSCC than in the corresponding adjacent non-neoplastic 
      tissues. Patients with T3-4 stage, neck nodal metastasis or advanced clinical 
      stage had higher hsa_circRNA_100855 expression. The hsa_circRNA_104912 level was 
      significantly lower in LSCC than in corresponding adjacent non-neoplastic 
      tissues. Patients with T3-4 stage, neck nodal metastasis, poor differentiation or 
      advanced clinical stage had a lower hsa_circRNA_104912 expression. Overall, our 
      data suggest that circRNAs play an important role in the tumorigenesis of LSCC 
      and may serve as novel and stable biomarkers for the diagnosis and progress of 
      LSCC.
FAU - Xuan, Lijia
AU  - Xuan L
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University Harbin, China.
FAU - Qu, Lingmei
AU  - Qu L
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Fifth Affiliated 
      Hospital, Harbin Medical University Daqing, China.
FAU - Zhou, Han
AU  - Zhou H
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University Harbin, China.
FAU - Wang, Peng
AU  - Wang P
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University Harbin, China.
FAU - Yu, Haoyang
AU  - Yu H
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University Harbin, China.
FAU - Wu, Tianyi
AU  - Wu T
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University Harbin, China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University Harbin, China.
FAU - Li, Qiuying
AU  - Li Q
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University Harbin, China.
FAU - Tian, Linli
AU  - Tian L
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University Harbin, China.
FAU - Liu, Ming
AU  - Liu M
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University Harbin, China.
FAU - Sun, Yanan
AU  - Sun Y
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University Harbin, China.
LA  - eng
PT  - Journal Article
DEP - 20160215
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC4846937
OTO - NOTNLM
OT  - Laryngeal squamous cell cancer (LSCC)
OT  - circular RNAs
OT  - noncoding RNA
OT  - progress
EDAT- 2016/05/10 06:00
MHDA- 2016/05/10 06:01
PMCR- 2016/02/15
CRDT- 2016/05/10 06:00
PHST- 2015/12/07 00:00 [received]
PHST- 2016/02/12 00:00 [accepted]
PHST- 2016/05/10 06:00 [entrez]
PHST- 2016/05/10 06:00 [pubmed]
PHST- 2016/05/10 06:01 [medline]
PHST- 2016/02/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2016 Feb 15;8(2):932-9. eCollection 2016.