PMID- 27159777
OWN - NLM
STAT- MEDLINE
DCOM- 20171222
LR  - 20180826
IS  - 1365-2222 (Electronic)
IS  - 0954-7894 (Linking)
VI  - 46
IP  - 7
DP  - 2016 Jul
TI  - Dendritic cells in inflammatory sinonasal diseases.
PG  - 894-906
LID - 10.1111/cea.12755 [doi]
AB  - Dendritic cells (DCs) are critical in linking the innate and adaptive immune 
      responses, which have been implicated in the pathogenesis of many immune and 
      inflammatory diseases as well as the development of tumours. The role of DCs in 
      the pathophysiology of lung diseases has been widely studied. However, the 
      phenotype, subset and function of DCs in upper airways under physiological or 
      pathological conditions remain largely undefined. Allergic rhinitis (AR) and 
      chronic rhinosinusitis (CRS) are two important upper airway diseases with a high 
      worldwide prevalence. Aberrant innate and adaptive immune responses have been 
      considered to play an important role in the pathogenesis of AR and CRS. To this 
      end, understanding the function of DCs in shaping the immune responses in 
      sinonasal mucosa is critical in exploring the pathogenic mechanisms underlying AR 
      and CRS as well as in developing novel therapeutic strategies. This review 
      summarizes the phenotype, subset, function and regulation of DCs in sinonasal 
      mucosa, particularly in the setting of AR and CRS. Furthermore, this review 
      discusses the perspectives for future research and potential clinical utility 
      focusing on DC pathways in the context of AR and CRS.
CI  - (c) 2016 John Wiley & Sons Ltd.
FAU - Cao, P-P
AU  - Cao PP
AD  - Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Shi, L-L
AU  - Shi LL
AD  - Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Xu, K
AU  - Xu K
AD  - Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Yao, Y
AU  - Yao Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Liu, Z
AU  - Liu Z
AD  - Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160606
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
SB  - IM
MH  - Animals
MH  - Chronic Disease
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Humans
MH  - Mice
MH  - Respiratory System/immunology/metabolism
MH  - Rhinitis, Allergic/immunology/metabolism/therapy
MH  - Sinusitis/*immunology/*metabolism/therapy
EDAT- 2016/05/10 06:00
MHDA- 2017/12/23 06:00
CRDT- 2016/05/10 06:00
PHST- 2016/05/10 06:00 [entrez]
PHST- 2016/05/10 06:00 [pubmed]
PHST- 2017/12/23 06:00 [medline]
AID - 10.1111/cea.12755 [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2016 Jul;46(7):894-906. doi: 10.1111/cea.12755. Epub 2016 Jun 
      6.