PMID- 27159879
OWN - NLM
STAT- MEDLINE
DCOM- 20171019
LR  - 20181113
IS  - 2164-554X (Electronic)
IS  - 2164-5515 (Print)
IS  - 2164-5515 (Linking)
VI  - 12
IP  - 8
DP  - 2016 Aug 2
TI  - Multifunctional particle-constituted microneedle arrays as cutaneous or mucosal 
      vaccine adjuvant-delivery systems.
PG  - 2075-2089
AB  - To overcome drawbacks of current injection vaccines, such as causing needle 
      phobia, needing health professionals for inoculation, and generating dangerous 
      sharps wastes, researchers have designed novel vaccines that are combined with 
      various microneedle arrays (MAs), in particular, with the multifunctional 
      particle-constructed MAs (MPMAs). MPMAs prove able to enhance vaccine stability 
      through incorporating vaccine ingredients in the carrier, and can be painlessly 
      inoculated by minimally trained workers or by self-administration, leaving behind 
      no metal needle pollution while eliciting robust systemic and mucosal immunity to 
      antigens, thanks to delivering vaccines to cutaneous or mucosal compartments 
      enriched in professional antigen-presenting cells (APCs). Especially, MPMAs can 
      be easily integrated with functional molecules fulfilling targeting vaccine 
      delivery or controlling immune response toward a Th1 or Th2 pathway to generate 
      desired immunity against pathogens. Herein, we introduce the latest research and 
      development of various MPMAs which are a novel but promising vaccine adjuvant 
      delivery system (VADS).
FAU - Wang, Xueting
AU  - Wang X
AD  - a School of Pharmacy, Anhui Medical University , Hefei , China.
FAU - Wang, Ning
AU  - Wang N
AD  - b School of Medical Engineering, Hefei University of Technology , Hefei , China.
FAU - Li, Ning
AU  - Li N
AD  - a School of Pharmacy, Anhui Medical University , Hefei , China.
FAU - Zhen, Yuanyuan
AU  - Zhen Y
AD  - a School of Pharmacy, Anhui Medical University , Hefei , China.
FAU - Wang, Ting
AU  - Wang T
AD  - a School of Pharmacy, Anhui Medical University , Hefei , China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160509
PL  - United States
TA  - Hum Vaccin Immunother
JT  - Human vaccines & immunotherapeutics
JID - 101572652
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Vaccines)
SB  - IM
MH  - Adjuvants, Immunologic/*administration & dosage
MH  - *Administration, Cutaneous
MH  - *Administration, Mucosal
MH  - Animals
MH  - Drug Delivery Systems/*methods
MH  - Humans
MH  - Vaccines/*administration & dosage
PMC - PMC4994742
OTO - NOTNLM
OT  - C-type lectin receptor
OT  - Liposome
OT  - adjuvant
OT  - controlled temperature chain
OT  - intradermal immunization
OT  - microneedle array
OT  - mucosal immunity
OT  - nanoparticles
OT  - toll-like receptor
EDAT- 2016/05/10 06:00
MHDA- 2017/10/20 06:00
PMCR- 2017/05/09
CRDT- 2016/05/10 06:00
PHST- 2016/05/10 06:00 [pubmed]
PHST- 2017/10/20 06:00 [medline]
PHST- 2016/05/10 06:00 [entrez]
PHST- 2017/05/09 00:00 [pmc-release]
AID - 1158368 [pii]
AID - 10.1080/21645515.2016.1158368 [doi]
PST - ppublish
SO  - Hum Vaccin Immunother. 2016 Aug 2;12(8):2075-2089. doi: 
      10.1080/21645515.2016.1158368. Epub 2016 May 9.