PMID- 27161127
OWN - NLM
STAT- MEDLINE
DCOM- 20170403
LR  - 20201209
IS  - 1573-0832 (Electronic)
IS  - 0301-486X (Linking)
VI  - 181
IP  - 9-10
DP  - 2016 Oct
TI  - Paracoccidioides brasiliensis PS2: First Autochthonous Paracoccidioidomycosis 
      Case Report in Rio de Janeiro, Brazil, and Literature Review.
PG  - 701-8
LID - 10.1007/s11046-016-0015-6 [doi]
AB  - Paracoccidioidomycosis (PCM) is a systemic mycosis caused by pathogenic dimorphic 
      fungi of the Paracoccidioides brasiliensis complex. It is the most important 
      systemic mycosis in Latin America, mainly in Brazil. Despite its severity and 
      high mortality rates, it is considered a neglected disease. Species within the 
      genus Paracoccidioides present genetics and morphological variations with 
      probable clinical, diagnostic and therapeutic consequences. In fact, there are a 
      very small number of detailed case reports with molecular identification of these 
      fungal agents. Here, it is reported a case of PCM due to Paracoccidioides 
      brasiliensis PS2. Molecular identification of the isolate was performed by 
      amplification and sequencing of the arf and gp43 genes. Clinical cases and strain 
      reports with molecular identification in the literature are also reviewed. The 
      case herein presented is the first autochthonous report of PCM due to 
      Paracoccidioides brasiliensis PS2 species in the state of Rio de Janeiro, Brazil, 
      an important endemic area. The patient presented a chronic pulmonary form of PCM 
      and had a satisfactory response to sulfamethoxazole/trimethoprim although 
      sequelae such as adrenal insufficiency and dysphonia were observed. This study 
      may contribute to improve the knowledge about this severe disease, its causative 
      cryptic species and their consequences to patients.
FAU - de Macedo, Priscila Marques
AU  - de Macedo PM
AD  - Laboratorio de Pesquisa Clinica em Dermatologia Infecciosa, Instituto Nacional de 
      Infectologia Evandro Chagas, Fundacao Oswaldo Cruz, Avenida Brasil, 4365, 
      Manguinhos, Rio de Janeiro, RJ, 21045-900, Brazil. 
      priscila.marques@ini.fiocruz.br.
FAU - Almeida-Paes, Rodrigo
AU  - Almeida-Paes R
AD  - Laboratorio de Micologia, Instituto Nacional de Infectologia Evandro Chagas, 
      Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
FAU - de Medeiros Muniz, Mauro
AU  - de Medeiros Muniz M
AD  - Laboratorio de Micologia, Instituto Nacional de Infectologia Evandro Chagas, 
      Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
FAU - Oliveira, Manoel Marques Evangelista
AU  - Oliveira MM
AD  - Laboratorio de Micologia, Instituto Nacional de Infectologia Evandro Chagas, 
      Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
FAU - Zancope-Oliveira, Rosely Maria
AU  - Zancope-Oliveira RM
AD  - Laboratorio de Micologia, Instituto Nacional de Infectologia Evandro Chagas, 
      Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
FAU - Costa, Regina Lana Braga
AU  - Costa RL
AD  - Coordenacao de Pesquisa, Instituto Nacional de Infectologia Evandro Chagas, 
      Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
FAU - do Valle, Antonio Carlos Francesconi
AU  - do Valle AC
AD  - Laboratorio de Pesquisa Clinica em Dermatologia Infecciosa, Instituto Nacional de 
      Infectologia Evandro Chagas, Fundacao Oswaldo Cruz, Avenida Brasil, 4365, 
      Manguinhos, Rio de Janeiro, RJ, 21045-900, Brazil.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160509
PL  - Netherlands
TA  - Mycopathologia
JT  - Mycopathologia
JID - 7505689
RN  - 0 (43 kDa protein, Paracoccidioides)
RN  - 0 (Antigens, Fungal)
RN  - 0 (Fungal Proteins)
RN  - 0 (Glycoproteins)
RN  - EC 3.6.5.2 (ADP-Ribosylation Factors)
SB  - IM
MH  - ADP-Ribosylation Factors/genetics
MH  - Adult
MH  - Antigens, Fungal/genetics
MH  - Brazil
MH  - Cluster Analysis
MH  - Fungal Proteins/genetics
MH  - Glycoproteins/genetics
MH  - Humans
MH  - Lung Diseases, Fungal/diagnosis/*microbiology/*pathology
MH  - Male
MH  - Paracoccidioides/classification/genetics/*isolation & purification
MH  - Paracoccidioidomycosis/diagnosis/*microbiology/*pathology
MH  - Phylogeny
MH  - Sequence Analysis, DNA
MH  - Sequence Homology
OTO - NOTNLM
OT  - Molecular identification
OT  - Paracoccidioides brasiliensis PS2
OT  - Paracoccidioidomycosis
OT  - Pulmonary chronic disease
EDAT- 2016/05/11 06:00
MHDA- 2017/04/04 06:00
CRDT- 2016/05/11 06:00
PHST- 2016/03/07 00:00 [received]
PHST- 2016/04/25 00:00 [accepted]
PHST- 2016/05/11 06:00 [entrez]
PHST- 2016/05/11 06:00 [pubmed]
PHST- 2017/04/04 06:00 [medline]
AID - 10.1007/s11046-016-0015-6 [pii]
AID - 10.1007/s11046-016-0015-6 [doi]
PST - ppublish
SO  - Mycopathologia. 2016 Oct;181(9-10):701-8. doi: 10.1007/s11046-016-0015-6. Epub 
      2016 May 9.