PMID- 27161360
OWN - NLM
STAT- MEDLINE
DCOM- 20171020
LR  - 20180117
IS  - 1832-4274 (Print)
IS  - 1832-4274 (Linking)
VI  - 19
IP  - 4
DP  - 2016 Aug
TI  - Increased Fetal Plasma Erythropoietin in Monochorionic Twin Pregnancies With 
      Selective Intrauterine Growth Restriction and Abnormal Umbilical Artery Doppler.
PG  - 383-8
LID - 10.1017/thg.2016.38 [doi]
AB  - Hypoxia is the primary stimulus for the production of erythropoietin (EPO) in 
      both fetal and adult life. Here, we investigated fetal plasma EPO concentrations 
      in monochorionic (MC) twin pregnancies with selective intrauterine growth 
      restriction (sIUGR) and abnormal umbilical artery (UA) Doppler. We diagnosed 
      sIUGR in presence of (1) birth-weight discordance >20% and (2) either twin with a 
      birth weight <10th percentile. An abnormal UA Doppler was defined as a persistent 
      absent-reverse end diastolic flow (AREDF). The intertwin EPO ratio was calculated 
      as the plasma EPO level of the smaller (or small-for-gestational-age) twin 
      divided by the EPO concentration of the larger (or 
      appropriate-for-gestational-age (AGA)) twin. Thirty-two MC twin pairs were 
      included. Of these, 17 pairs were normal twins (Group 1), seven pairs were twins 
      with sIUGR without UA Doppler abnormalities (Group 2), and eight pairs were twins 
      with sIUGR and UA Doppler abnormalities (Group 3). The highest EPO ratio was 
      identified in Group 3 (p < .001) but no significant differences were observed 
      between Groups 1 and 2. Fetal hemoglobin levels did not differ significantly in 
      the three groups, and fetal EPO concentration did not correlate with gestational 
      age at birth. We conclude that fetal plasma EPO concentrations are selectively 
      increased in MC twin pregnancies with sIUGR and abnormal UA Doppler, possibly as 
      a result of uncompensated hypoxia.
FAU - Chang, Yao-Lung
AU  - Chang YL
AD  - Department of Obstetrics and Gynecology,Chang Gung Memorial 
      Hospital,Linkou,College of Medicine,Chang Gung University,Taoyuan,Taiwan.
FAU - Chao, An-Shine
AU  - Chao AS
AD  - Department of Obstetrics and Gynecology,Chang Gung Memorial 
      Hospital,Linkou,College of Medicine,Chang Gung University,Taoyuan,Taiwan.
FAU - Peng, Hsiu-Huei
AU  - Peng HH
AD  - Department of Obstetrics and Gynecology,Chang Gung Memorial 
      Hospital,Linkou,College of Medicine,Chang Gung University,Taoyuan,Taiwan.
FAU - Chang, Shuenn-Dyh
AU  - Chang SD
AD  - Department of Obstetrics and Gynecology,Chang Gung Memorial 
      Hospital,Linkou,College of Medicine,Chang Gung University,Taoyuan,Taiwan.
FAU - Su, Sheng-Yuan
AU  - Su SY
AD  - Department of Obstetrics and Gynecology,Chang Gung Memorial 
      Hospital,Linkou,College of Medicine,Chang Gung University,Taoyuan,Taiwan.
FAU - Chen, Kuan-Ju
AU  - Chen KJ
AD  - Department of Obstetrics and Gynecology,Chang Gung Memorial 
      Hospital,Linkou,College of Medicine,Chang Gung University,Taoyuan,Taiwan.
FAU - Cheng, Po-Jen
AU  - Cheng PJ
AD  - Department of Obstetrics and Gynecology,Chang Gung Memorial 
      Hospital,Linkou,College of Medicine,Chang Gung University,Taoyuan,Taiwan.
FAU - Wang, Tzu-Hao
AU  - Wang TH
AD  - Department of Obstetrics and Gynecology,Chang Gung Memorial 
      Hospital,Linkou,College of Medicine,Chang Gung University,Taoyuan,Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20160510
PL  - England
TA  - Twin Res Hum Genet
JT  - Twin research and human genetics : the official journal of the International 
      Society for Twin Studies
JID - 101244624
RN  - 11096-26-7 (Erythropoietin)
SB  - IM
MH  - Chorion
MH  - Diseases in Twins/blood/diagnosis
MH  - Erythropoietin/*blood
MH  - Female
MH  - Fetal Growth Retardation/blood/*diagnostic imaging
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Pregnancy
MH  - Pregnancy, Twin/*blood
MH  - Ultrasonography, Doppler
MH  - Ultrasonography, Prenatal
MH  - Umbilical Arteries/abnormalities/*diagnostic imaging
OTO - NOTNLM
OT  - erythropoietin
OT  - intrauterine growth restriction
OT  - monochorionic twin pregnancy
OT  - placenta
EDAT- 2016/05/11 06:00
MHDA- 2017/10/21 06:00
CRDT- 2016/05/11 06:00
PHST- 2016/05/11 06:00 [entrez]
PHST- 2016/05/11 06:00 [pubmed]
PHST- 2017/10/21 06:00 [medline]
AID - S1832427416000384 [pii]
AID - 10.1017/thg.2016.38 [doi]
PST - ppublish
SO  - Twin Res Hum Genet. 2016 Aug;19(4):383-8. doi: 10.1017/thg.2016.38. Epub 2016 May 
      10.