PMID- 27161370
OWN - NLM
STAT- MEDLINE
DCOM- 20170417
LR  - 20181113
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 41
IP  - 9
DP  - 2016 Sep
TI  - Histone Acetylation Regulation in Sleep Deprivation-Induced Spatial Memory 
      Impairment.
PG  - 2223-32
LID - 10.1007/s11064-016-1937-6 [doi]
AB  - Sleep disorders negatively affect cognition and health. Recent evidence has 
      indicated that chromatin remodeling via histone acetylation regulates cognitive 
      function. This study aimed to investigate the possible roles of histone 
      acetylation in sleep deprivation (SD)-induced cognitive impairment. Results of 
      the Morris water maze test showed that 3 days of SD can cause spatial memory 
      impairment in Wistar rats. SD can also decrease histone acetylation levels, 
      increase histone deacetylase 2 (HDAC2) expression, and decrease histone 
      acetyltransferase (CBP) expression. Furthermore, SD can reduce H3 and H4 
      acetylation levels in the promoters of the brain-derived neurotrophic factor 
      (Bdnf) gene and thus significantly downregulate BDNF expression and impair the 
      activity of key BDNF signaling pathways (pCaMKII, pErk2, and pCREB). However, 
      treatment with the HDAC inhibitor trichostatin A attenuated all the negative 
      effects induced by SD. Therefore, BDNF and its histone acetylation regulation may 
      play important roles in SD-induced spatial memory impairment, whereas HDAC 
      inhibition possibly confers protection against SD-induced impairment in spatial 
      memory and hippocampal functions.
FAU - Duan, Ruifeng
AU  - Duan R
AD  - Tianjin Institute of Health and Environmental Medicine, Tianjin, China.
FAU - Liu, Xiaohua
AU  - Liu X
AD  - Tianjin Institute of Health and Environmental Medicine, Tianjin, China.
FAU - Wang, Tianhui
AU  - Wang T
AD  - Tianjin Institute of Health and Environmental Medicine, Tianjin, China.
FAU - Wu, Lei
AU  - Wu L
AD  - Tianjin Institute of Health and Environmental Medicine, Tianjin, China.
FAU - Gao, Xiujie
AU  - Gao X
AD  - Tianjin Institute of Health and Environmental Medicine, Tianjin, China.
FAU - Zhang, Zhiqing
AU  - Zhang Z
AD  - Tianjin Institute of Health and Environmental Medicine, Tianjin, China. 
      camelhuifeng@126.com.
LA  - eng
PT  - Journal Article
DEP - 20160509
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Histones)
RN  - EC 3.5.1.98 (Histone Deacetylase 2)
SB  - IM
MH  - Acetylation
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Epigenesis, Genetic/physiology
MH  - Hippocampus/*metabolism
MH  - Histone Deacetylase 2/metabolism
MH  - Histones/*metabolism
MH  - Male
MH  - Memory Disorders/*etiology/metabolism
MH  - Protein Processing, Post-Translational/genetics
MH  - Rats, Wistar
MH  - Sleep Deprivation/*complications/metabolism
MH  - Spatial Memory/*physiology
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Histone acetylation
OT  - Histone deacetylase
OT  - Sleep deprivation
OT  - Spatial memory
EDAT- 2016/05/11 06:00
MHDA- 2017/04/18 06:00
CRDT- 2016/05/11 06:00
PHST- 2015/12/28 00:00 [received]
PHST- 2016/04/25 00:00 [accepted]
PHST- 2016/03/16 00:00 [revised]
PHST- 2016/05/11 06:00 [entrez]
PHST- 2016/05/11 06:00 [pubmed]
PHST- 2017/04/18 06:00 [medline]
AID - 10.1007/s11064-016-1937-6 [pii]
AID - 10.1007/s11064-016-1937-6 [doi]
PST - ppublish
SO  - Neurochem Res. 2016 Sep;41(9):2223-32. doi: 10.1007/s11064-016-1937-6. Epub 2016 
      May 9.