PMID- 27161518 OWN - NLM STAT- MEDLINE DCOM- 20180321 LR - 20221207 IS - 1873-460X (Electronic) IS - 1056-8727 (Linking) VI - 30 IP - 6 DP - 2016 Aug TI - Urine uric acid excretion is associated with nonalcoholic fatty liver disease in patients with type 2 diabetes. PG - 1074-80 LID - S1056-8727(16)30116-7 [pii] LID - 10.1016/j.jdiacomp.2016.04.017 [doi] AB - AIMS: Elevated serum uric acid is closely associated with nonalcoholic fatty liver disease (NAFLD). However, the association of urine uric acid excretion (UUAE) with NAFLD has not been investigated. Our aims were to explore the associations between UUAE and NAFLD and serum alanine aminotransferase (ALT) in type 2 diabetes mellitus (T2DM). METHODS: This cross-sectional study included 2042 Chinese inpatients with T2DM. UUAE was determined enzymatically using a single 24-h urine collection. The subjects were stratified into quartile based on UUAE levels. NAFLD was determined by ultrasonography. Elevated ALT level was defined with an ALT value >65U/L. RESULTS: There was an obvious increase in both NAFLD prevalence (26.3%, 34.6%, 43.8%, and 56.2%, respectively, p<0.001 for trend) and ALT value [16 (12-24), 17 (13-27), 20 (14-30), and 24 (15-38) U/L, respectively, p<0.001 for trend] across the UUAE quartiles after controlling for confounders. Multiple logistic regression analyses revealed independent associations between UUAE and NAFLD (p=0.002) and elevated ALT level (p<0.001). Compared with the patients in the first quartile of UUAE, those in the second, third and fourth quartiles had 1.528-, 1.869-, and 1.906-fold risk of NAFLD, and 3.620-, 6.223-, and 10.506-fold risk of elevated ALT level in T2DM, respectively. CONCLUSIONS: Increased UUAE levels were significantly associated with the presence of NAFLD and increase of ALT in T2DM. UUAE may be a clinically significant measure in assessing the risk of NAFLD in T2DM. CI - Copyright (c) 2016 Elsevier Inc. All rights reserved. FAU - Zhao, Cui-Chun AU - Zhao CC AD - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, 600 Yishan Road, Shanghai, 200233, China; Department of VIP, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China. FAU - Wang, Ai-Ping AU - Wang AP AD - Department of Endocrinology, 454 hospital of PLA, Nanjing, Jiangsu Province, China, 210002. FAU - Li, Lian-Xi AU - Li LX AD - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, 600 Yishan Road, Shanghai, 200233, China. Electronic address: lilx@sjtu.edu.cn. FAU - Li, Ting-Ting AU - Li TT AD - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, 600 Yishan Road, Shanghai, 200233, China. FAU - Chen, Ming-Yun AU - Chen MY AD - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, 600 Yishan Road, Shanghai, 200233, China. FAU - Zhu, Yue AU - Zhu Y AD - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, 600 Yishan Road, Shanghai, 200233, China. FAU - Yu, Tian-Pei AU - Yu TP AD - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, 600 Yishan Road, Shanghai, 200233, China. FAU - Bao, Yu-Qian AU - Bao YQ AD - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, 600 Yishan Road, Shanghai, 200233, China. FAU - Jia, Wei-Ping AU - Jia WP AD - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, 600 Yishan Road, Shanghai, 200233, China. Electronic address: wpjia@sjtu.edu.cn. LA - eng PT - Journal Article DEP - 20160426 PL - United States TA - J Diabetes Complications JT - Journal of diabetes and its complications JID - 9204583 RN - 268B43MJ25 (Uric Acid) SB - IM MH - Adult MH - Aged MH - Asian People MH - China MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/complications/*urine MH - Female MH - Humans MH - Male MH - Middle Aged MH - Non-alcoholic Fatty Liver Disease/complications/*urine MH - Risk Factors MH - Uric Acid/*urine OTO - NOTNLM OT - Alanine aminotransferase OT - Nonalcoholic fatty liver disease OT - Type 2 diabetes mellitus OT - Uric acid OT - Urine uric acid excretion EDAT- 2016/05/11 06:00 MHDA- 2018/03/22 06:00 CRDT- 2016/05/11 06:00 PHST- 2016/01/01 00:00 [received] PHST- 2016/04/21 00:00 [revised] PHST- 2016/04/22 00:00 [accepted] PHST- 2016/05/11 06:00 [entrez] PHST- 2016/05/11 06:00 [pubmed] PHST- 2018/03/22 06:00 [medline] AID - S1056-8727(16)30116-7 [pii] AID - 10.1016/j.jdiacomp.2016.04.017 [doi] PST - ppublish SO - J Diabetes Complications. 2016 Aug;30(6):1074-80. doi: 10.1016/j.jdiacomp.2016.04.017. Epub 2016 Apr 26.