PMID- 27162100
OWN - NLM
STAT- MEDLINE
DCOM- 20170808
LR  - 20220318
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 26
IP  - 7
DP  - 2016 Jul
TI  - Serum uric acid level and left ventricular hypertrophy in elderly male patients 
      with nonvalvular atrial fibrillation.
PG  - 575-580
LID - S0939-4753(15)30180-0 [pii]
LID - 10.1016/j.numecd.2016.03.011 [doi]
AB  - BACKGROUND AND AIMS: Recent studies have suggested that serum uric acid (SUA) 
      induces oxidative stress and inflammation, which are involved in the mechanism of 
      cardiac hypertrophy. In patients with atrial fibrillation (AF), comorbidity of 
      left ventricular hypertrophy (LVH) exacerbates cardiac function. In this study, 
      we investigated the association between SUA and cardiac hypertrophy in AF 
      patients. METHODS AND RESULTS: Initially, 1296 consecutive elderly patients (age 
      >60) with nonvalvular AF were retrospectively selected from the inpatient clinic 
      between January 2012 and April 2015. Demographic, clinical, and echocardiographic 
      characteristics were carefully recorded. The final study population was 577 
      patients. The mean SUA level was significantly higher in patients with LVH than 
      those without LVH. Compared with the non-LVH group, the LVH group was older, had 
      a higher percentage of female patients, and had lower hemoglobin levels and 
      estimated glomerular filtration rates. Patients in the LVH group also had a 
      higher rate of coronary heart disease and fewer had history of radiofrequency 
      ablation compared with the non-LVH group. In the hyperuricemia group, B-type 
      natriuretic peptide levels, left atrial diameter, left ventricular mass index, 
      and percentage of NYHA (New York Heart Association) class III/IV were 
      significantly higher than the SUA normal group. Multivariate logistic regression 
      analysis indicated the independent risk factors for LVH in elderly AF patients 
      included SUA, age, male sex, the presence of coronary heart disease, and diuretic 
      therapy. Subgroup analysis identified SUA as a significant risk factor associated 
      with LVH in men. CONCLUSIONS: SUA was independently associated with LVH in 
      elderly male patients with nonvalvular AF.
CI  - Copyright (c) 2016 The Italian Society of Diabetology, the Italian Society for the 
      Study of Atherosclerosis, the Italian Society of Human Nutrition, and the 
      Department of Clinical Medicine and Surgery, Federico II University. Published by 
      Elsevier B.V. All rights reserved.
FAU - Liang, W Y
AU  - Liang WY
AD  - Department of Geriatrics, Peking University First Hospital, Beijing, People's 
      Republic of China.
FAU - Liu, W W
AU  - Liu WW
AD  - Department of Geriatrics, Peking University First Hospital, Beijing, People's 
      Republic of China.
FAU - Liu, M L
AU  - Liu ML
AD  - Department of Geriatrics, Peking University First Hospital, Beijing, People's 
      Republic of China. Electronic address: meilinliu@yahoo.com.
FAU - Xiang, W
AU  - Xiang W
AD  - Department of Geriatrics, Peking University First Hospital, Beijing, People's 
      Republic of China.
FAU - Feng, X R
AU  - Feng XR
AD  - Department of Geriatrics, Peking University First Hospital, Beijing, People's 
      Republic of China.
FAU - Huang, B
AU  - Huang B
AD  - Department of Geriatrics, Peking University First Hospital, Beijing, People's 
      Republic of China.
FAU - Chen, X H
AU  - Chen XH
AD  - Department of Geriatrics, Peking University First Hospital, Beijing, People's 
      Republic of China.
FAU - Sun, Y S
AU  - Sun YS
AD  - Department of Geriatrics, Peking University First Hospital, Beijing, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20160331
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Biomarkers)
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrial Fibrillation/*complications/diagnosis
MH  - Biomarkers/blood
MH  - Chi-Square Distribution
MH  - Humans
MH  - Hypertrophy, Left Ventricular/diagnostic imaging/*etiology/physiopathology
MH  - Hyperuricemia/blood/diagnosis/*etiology
MH  - Logistic Models
MH  - Male
MH  - Multivariate Analysis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Up-Regulation
MH  - Uric Acid/*blood
MH  - *Ventricular Function, Left
MH  - *Ventricular Remodeling
OTO - NOTNLM
OT  - Atrial fibrillation
OT  - Left ventricular hypertrophy
OT  - Serum uric acid
EDAT- 2016/05/11 06:00
MHDA- 2017/08/09 06:00
CRDT- 2016/05/11 06:00
PHST- 2015/08/24 00:00 [received]
PHST- 2016/03/10 00:00 [revised]
PHST- 2016/03/15 00:00 [accepted]
PHST- 2016/05/11 06:00 [entrez]
PHST- 2016/05/11 06:00 [pubmed]
PHST- 2017/08/09 06:00 [medline]
AID - S0939-4753(15)30180-0 [pii]
AID - 10.1016/j.numecd.2016.03.011 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2016 Jul;26(7):575-580. doi: 
      10.1016/j.numecd.2016.03.011. Epub 2016 Mar 31.