PMID- 27162678
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160510
LR  - 20200930
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 8
IP  - 5
DP  - 2016 May
TI  - A multi-center evaluation of a powered surgical stapler in video-assisted 
      thoracoscopic lung resection procedures in China.
PG  - 1007-13
LID - 10.21037/jtd.2016.03.88 [doi]
AB  - BACKGROUND: Lung cancer is one of the most prevalent malignancies worldwide. The 
      number of anatomic lung cancer resections performed via video-assisted 
      thoracoscopic surgery (VATS) is growing rapidly. Staplers are widely used in VATS 
      procedures, but there is limited clinical data regarding how they might affect 
      performance and postoperative outcomes, including air leak. This clinical trial 
      assessed the use of a powered stapler in VATS lung resection, with a primary 
      study endpoint being occurrence and duration of air leak and prolonged air leak 
      (PAL). METHODS: Data was collected from a single arm, multi-center study in 
      Chinese patients receiving VATS wedge resection or lobectomy. Intra-operative 
      data included surgery duration; cartridge selection for ligation/transection of 
      bronchus, major vessels, and lung parenchyma; staple line interventions; blood 
      loss; and device usage. Post-operative data included air leak assessments, chest 
      tube duration, length of hospital stay, and adverse events (AEs). RESULTS: A 
      total of 94 procedures across four institutions in China were included in the 
      final analysis: 15 wedge resections, 74 lobectomies, and five wedge resections 
      followed by lobectomies. Post-operative air leak occurred in five (5.3%) patients 
      who had lobectomy procedures, with PAL in one (1.1%) patient. Sites were 
      generally consistent relative to cartridge use by tissue type. The incidence of 
      stapler firings requiring surgical interventions was seven out of 550 (1.3%). 
      Surgeons participating in the study were satisfied with the articulation and 
      overall usability of the stapler. CONCLUSIONS: The powered staplers make the VATS 
      procedure easier for the surgeons and have achieved intra- and post-operative 
      patient outcomes comparable to those previously reported.
FAU - Qiu, Bin
AU  - Qiu B
AD  - 1 Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical 
      Sciences, Beijing 100021, China ; 2 Key Laboratory of Carcinogenesis and 
      Translational Research (Ministry of Education/Beijing), The First Department of 
      Thoracic Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, 
      China ; 3 Department of Thoracic Surgery, Tongji Hospital, Tongji Medical 
      College, Huazhong University of Science & Technology, Wuhan 430030, China ; 4 
      Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang 
      University, Hangzhou 310003, China ; 5 Clinical R&D Center of Excellence, 6 
      Medical Affairs Center of Excellence, Ethicon, Cincinnati, Ohio, USA ; 7 
      Strategic Medical Affairs, Johnson & Johnson Medical (Shanghai) Ltd., Shanghai 
      200030, China.
FAU - Yan, Wanpu
AU  - Yan W
AD  - 1 Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical 
      Sciences, Beijing 100021, China ; 2 Key Laboratory of Carcinogenesis and 
      Translational Research (Ministry of Education/Beijing), The First Department of 
      Thoracic Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, 
      China ; 3 Department of Thoracic Surgery, Tongji Hospital, Tongji Medical 
      College, Huazhong University of Science & Technology, Wuhan 430030, China ; 4 
      Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang 
      University, Hangzhou 310003, China ; 5 Clinical R&D Center of Excellence, 6 
      Medical Affairs Center of Excellence, Ethicon, Cincinnati, Ohio, USA ; 7 
      Strategic Medical Affairs, Johnson & Johnson Medical (Shanghai) Ltd., Shanghai 
      200030, China.
FAU - Chen, Keneng
AU  - Chen K
AD  - 1 Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical 
      Sciences, Beijing 100021, China ; 2 Key Laboratory of Carcinogenesis and 
      Translational Research (Ministry of Education/Beijing), The First Department of 
      Thoracic Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, 
      China ; 3 Department of Thoracic Surgery, Tongji Hospital, Tongji Medical 
      College, Huazhong University of Science & Technology, Wuhan 430030, China ; 4 
      Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang 
      University, Hangzhou 310003, China ; 5 Clinical R&D Center of Excellence, 6 
      Medical Affairs Center of Excellence, Ethicon, Cincinnati, Ohio, USA ; 7 
      Strategic Medical Affairs, Johnson & Johnson Medical (Shanghai) Ltd., Shanghai 
      200030, China.
FAU - Fu, Xiangning
AU  - Fu X
AD  - 1 Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical 
      Sciences, Beijing 100021, China ; 2 Key Laboratory of Carcinogenesis and 
      Translational Research (Ministry of Education/Beijing), The First Department of 
      Thoracic Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, 
      China ; 3 Department of Thoracic Surgery, Tongji Hospital, Tongji Medical 
      College, Huazhong University of Science & Technology, Wuhan 430030, China ; 4 
      Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang 
      University, Hangzhou 310003, China ; 5 Clinical R&D Center of Excellence, 6 
      Medical Affairs Center of Excellence, Ethicon, Cincinnati, Ohio, USA ; 7 
      Strategic Medical Affairs, Johnson & Johnson Medical (Shanghai) Ltd., Shanghai 
      200030, China.
FAU - Hu, Jian
AU  - Hu J
AD  - 1 Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical 
      Sciences, Beijing 100021, China ; 2 Key Laboratory of Carcinogenesis and 
      Translational Research (Ministry of Education/Beijing), The First Department of 
      Thoracic Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, 
      China ; 3 Department of Thoracic Surgery, Tongji Hospital, Tongji Medical 
      College, Huazhong University of Science & Technology, Wuhan 430030, China ; 4 
      Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang 
      University, Hangzhou 310003, China ; 5 Clinical R&D Center of Excellence, 6 
      Medical Affairs Center of Excellence, Ethicon, Cincinnati, Ohio, USA ; 7 
      Strategic Medical Affairs, Johnson & Johnson Medical (Shanghai) Ltd., Shanghai 
      200030, China.
FAU - Gao, Shugeng
AU  - Gao S
AD  - 1 Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical 
      Sciences, Beijing 100021, China ; 2 Key Laboratory of Carcinogenesis and 
      Translational Research (Ministry of Education/Beijing), The First Department of 
      Thoracic Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, 
      China ; 3 Department of Thoracic Surgery, Tongji Hospital, Tongji Medical 
      College, Huazhong University of Science & Technology, Wuhan 430030, China ; 4 
      Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang 
      University, Hangzhou 310003, China ; 5 Clinical R&D Center of Excellence, 6 
      Medical Affairs Center of Excellence, Ethicon, Cincinnati, Ohio, USA ; 7 
      Strategic Medical Affairs, Johnson & Johnson Medical (Shanghai) Ltd., Shanghai 
      200030, China.
FAU - Knippenberg, Susan
AU  - Knippenberg S
AD  - 1 Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical 
      Sciences, Beijing 100021, China ; 2 Key Laboratory of Carcinogenesis and 
      Translational Research (Ministry of Education/Beijing), The First Department of 
      Thoracic Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, 
      China ; 3 Department of Thoracic Surgery, Tongji Hospital, Tongji Medical 
      College, Huazhong University of Science & Technology, Wuhan 430030, China ; 4 
      Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang 
      University, Hangzhou 310003, China ; 5 Clinical R&D Center of Excellence, 6 
      Medical Affairs Center of Excellence, Ethicon, Cincinnati, Ohio, USA ; 7 
      Strategic Medical Affairs, Johnson & Johnson Medical (Shanghai) Ltd., Shanghai 
      200030, China.
FAU - Schwiers, Michael
AU  - Schwiers M
AD  - 1 Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical 
      Sciences, Beijing 100021, China ; 2 Key Laboratory of Carcinogenesis and 
      Translational Research (Ministry of Education/Beijing), The First Department of 
      Thoracic Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, 
      China ; 3 Department of Thoracic Surgery, Tongji Hospital, Tongji Medical 
      College, Huazhong University of Science & Technology, Wuhan 430030, China ; 4 
      Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang 
      University, Hangzhou 310003, China ; 5 Clinical R&D Center of Excellence, 6 
      Medical Affairs Center of Excellence, Ethicon, Cincinnati, Ohio, USA ; 7 
      Strategic Medical Affairs, Johnson & Johnson Medical (Shanghai) Ltd., Shanghai 
      200030, China.
FAU - Kassis, Edmund
AU  - Kassis E
AD  - 1 Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical 
      Sciences, Beijing 100021, China ; 2 Key Laboratory of Carcinogenesis and 
      Translational Research (Ministry of Education/Beijing), The First Department of 
      Thoracic Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, 
      China ; 3 Department of Thoracic Surgery, Tongji Hospital, Tongji Medical 
      College, Huazhong University of Science & Technology, Wuhan 430030, China ; 4 
      Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang 
      University, Hangzhou 310003, China ; 5 Clinical R&D Center of Excellence, 6 
      Medical Affairs Center of Excellence, Ethicon, Cincinnati, Ohio, USA ; 7 
      Strategic Medical Affairs, Johnson & Johnson Medical (Shanghai) Ltd., Shanghai 
      200030, China.
FAU - Yang, Tengfei
AU  - Yang T
AD  - 1 Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical 
      Sciences, Beijing 100021, China ; 2 Key Laboratory of Carcinogenesis and 
      Translational Research (Ministry of Education/Beijing), The First Department of 
      Thoracic Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, 
      China ; 3 Department of Thoracic Surgery, Tongji Hospital, Tongji Medical 
      College, Huazhong University of Science & Technology, Wuhan 430030, China ; 4 
      Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang 
      University, Hangzhou 310003, China ; 5 Clinical R&D Center of Excellence, 6 
      Medical Affairs Center of Excellence, Ethicon, Cincinnati, Ohio, USA ; 7 
      Strategic Medical Affairs, Johnson & Johnson Medical (Shanghai) Ltd., Shanghai 
      200030, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC4842836
OTO - NOTNLM
OT  - Video-assisted thoracoscopic surgery (VATS)
OT  - articulation
OT  - lobectomy
OT  - powered stapler
OT  - prolonged air leakage
OT  - stapler
OT  - wedge resection
COIS- Conflicts of Interest: Dr. Edmund Kassis, Susan Knippenberg and Michael Schwiers 
      are employed by Ethicon. Tengfei Yang is employed by Johnson & Johnson Medical 
      (Shanghai) Ltd. The other authors have no conflicts of interest to declare.
EDAT- 2016/05/11 06:00
MHDA- 2016/05/11 06:01
PMCR- 2016/05/01
CRDT- 2016/05/11 06:00
PHST- 2016/05/11 06:00 [entrez]
PHST- 2016/05/11 06:00 [pubmed]
PHST- 2016/05/11 06:01 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - jtd-08-05-1007 [pii]
AID - 10.21037/jtd.2016.03.88 [doi]
PST - ppublish
SO  - J Thorac Dis. 2016 May;8(5):1007-13. doi: 10.21037/jtd.2016.03.88.