PMID- 27162723
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160510
LR  - 20200930
IS  - 2222-3959 (Print)
IS  - 2227-4898 (Electronic)
IS  - 2222-3959 (Linking)
VI  - 9
IP  - 4
DP  - 2016
TI  - Anti-inflammatory effect of Heliotropium indicum Linn on 
      lipopolysaccharide-induced uveitis in New Zealand white rabbits.
PG  - 528-35
LID - 10.18240/ijo.2016.04.08 [doi]
AB  - AIM: To investigate the anti-inflammatory effect of an aqueous whole plant 
      extract of Heliotropium indicum (HIE) on endotoxin-induced uveitis in New Zealand 
      white rabbits. METHODS: Clinical signs of uveitis including flares, iris 
      hyperemia and miosis, were sought for and scored in 1.0 mg/kg lipopolysaccharide 
      (LPS) -induced uveitic rabbits treated orally with HIE (30-300 mg/kg), 
      prednisolone (30 mg/kg), or normal saline (10 mL/kg). The number of 
      polymorphonuclear neutrophils infiltrating, the protein concentration, as well as 
      levels of tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), and monocyte 
      chemmoattrant protein-1 (MCP-1) in the aqueous humor after the various treatments 
      were also determined. A histopathological study of the anterior uveal was 
      performed. RESULTS: The extract and prednisolone-treatment significantly reduced 
      (P</=0.001) both the clinical scores of inflammation (1.0-1.8 compared to 4.40+/-0.40 
      in the normal saline-treated rabbits) and inflammatory cells infiltration. The 
      level of protein, and the concentrations of TNF-alpha, PGE2 and MCP-1 in the aqueous 
      humor were also significantly reduced (P</=0.001). Histopathological studies showed 
      normal uveal morphology in the HIE and prednisolone-treated rabbits while normal 
      saline-treated rabbits showed marked infiltration of inflammatory cells. 
      CONCLUSION: The HIE exhibits anti-inflammatory effect on LPS-induced uveitis 
      possibly by reducing the production of pro-inflammatory mediators.
FAU - Kyei, Samuel
AU  - Kyei S
AD  - Discipline of Optometry, School of Health Sciences, College of Health Sciences, 
      University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa; 
      Department of Optometry, School of Allied Health Sciences, University of Cape 
      Coast, PMB, Cape Coast, Ghana.
FAU - Koffuor, George Asumeng
AU  - Koffuor GA
AD  - Discipline of Optometry, School of Health Sciences, College of Health Sciences, 
      University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa; 
      Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, 
      College of Health Sciences, Kwame Nkrumah University of Science and Technology, 
      PMB, Kumasi, Ghana.
FAU - Ramkissoon, Paul
AU  - Ramkissoon P
AD  - Discipline of Optometry, School of Health Sciences, College of Health Sciences, 
      University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.
FAU - Ameyaw, Elvis Ofori
AU  - Ameyaw EO
AD  - Department of Biomedical and Forensic Sciences, School of Allied Health Science, 
      University of Cape Coast, PMB, Cape Coast, Ghana.
FAU - Asiamah, Emmanuel Akomanin
AU  - Asiamah EA
AD  - Department of Pathology, Komfo Anokye Teaching Hospital, P. O Box 1934, Kumasi, 
      Ghana.
LA  - eng
PT  - Journal Article
DEP - 20160418
PL  - China
TA  - Int J Ophthalmol
JT  - International journal of ophthalmology
JID - 101553860
PMC - PMC4853346
OTO - NOTNLM
OT  - heliotropium
OT  - iris hyperemia
OT  - monocyte chemotatic protein-1
OT  - polymorphonuclear neutrophil
OT  - prednisolone
OT  - prostaglandin E2
OT  - tumor necrosis factor-alpha
OT  - uveitis
EDAT- 2016/05/11 06:00
MHDA- 2016/05/11 06:01
PMCR- 2016/04/18
CRDT- 2016/05/11 06:00
PHST- 2015/11/05 00:00 [received]
PHST- 2016/02/14 00:00 [accepted]
PHST- 2016/05/11 06:00 [entrez]
PHST- 2016/05/11 06:00 [pubmed]
PHST- 2016/05/11 06:01 [medline]
PHST- 2016/04/18 00:00 [pmc-release]
AID - ijo-09-04-528 [pii]
AID - 10.18240/ijo.2016.04.08 [doi]
PST - epublish
SO  - Int J Ophthalmol. 2016 Apr 18;9(4):528-35. doi: 10.18240/ijo.2016.04.08. 
      eCollection 2016.