PMID- 27163752
OWN - NLM
STAT- MEDLINE
DCOM- 20171201
LR  - 20211204
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 310
DP  - 2016 Sep 1
TI  - Inhibition of mammalian target of rapamycin activation in the rostral anterior 
      cingulate cortex attenuates pain-related aversion in rats.
PG  - 51-8
LID - S0166-4328(16)30277-7 [pii]
LID - 10.1016/j.bbr.2016.05.011 [doi]
AB  - Pain is a complex experience that comprises both sensory and affective 
      dimensions. Mammalian target of rapamycin (mTOR) plays an important role in the 
      modulation of neuronal plasticity associated with the pathogenesis of pain 
      sensation. However, the role of mTOR in pain affect is unclear. Using a 
      formalin-induced conditioned place avoidance (F-CPA) test, the current study 
      investigated the effects of the mTOR specific inhibitor rapamycin on noxious 
      stimulation induced aversion in the rostral anterior cingulate cortex (rACC). 
      Intraplantar injection of 5% formalin was associated with significant activation 
      of mTOR, as well as p70 ribosomal S6 protein (p70S6K), its downstream effector, 
      in the rACC. The inhibition of mTOR activation with rapamycin disrupted 
      pain-related aversion; however, this inhibition did not affect formalin-induced 
      spontaneous nociceptive behaviors in rats. These findings demonstrated for the 
      first time that mTOR and its downstream pathway in the rACC contribute to the 
      induction of pain-related negative emotion.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Lu, Bo
AU  - Lu B
AD  - Department of Anesthesia, Ningbo NO. 2 Hospital, Ningbo 315010, PR China.
FAU - Jiang, Jingyan
AU  - Jiang J
AD  - Department of Anesthesia, Yinzhou Hospital Affiliated to Medical School of Ningbo 
      University, Ningbo 315040, PR China.
FAU - Sun, Jianliang
AU  - Sun J
AD  - Department of Anesthesia, Hangzhou Hospital Affiliated to Nanjing Medical 
      University, Hangzhou First People's Hospital, Hangzhou 310006, PR China.
FAU - Xiao, Chun
AU  - Xiao C
AD  - Department of Anesthesia, Hangzhou Hospital Affiliated to Nanjing Medical 
      University, Hangzhou First People's Hospital, Hangzhou 310006, PR China.
FAU - Meng, Bo
AU  - Meng B
AD  - Department of Anesthesia, Ningbo NO. 2 Hospital, Ningbo 315010, PR China.
FAU - Zheng, Jinwei
AU  - Zheng J
AD  - Department of Anesthesia, Ningbo NO. 2 Hospital, Ningbo 315010, PR China.
FAU - Li, Xiaoyu
AU  - Li X
AD  - Department of Anesthesia, Ningbo NO. 2 Hospital, Ningbo 315010, PR China.
FAU - Wang, Ruichun
AU  - Wang R
AD  - Department of Anesthesia, Ningbo NO. 2 Hospital, Ningbo 315010, PR China.
FAU - Wu, Guorong
AU  - Wu G
AD  - Department of Anesthesia, Ningbo NO. 2 Hospital, Ningbo 315010, PR China.
FAU - Chen, Junping
AU  - Chen J
AD  - Department of Anesthesia, Ningbo NO. 2 Hospital, Ningbo 315010, PR China. 
      Electronic address: 13858222873@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160506
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Analgesics)
RN  - 1HG84L3525 (Formaldehyde)
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Analgesics/pharmacology
MH  - Animals
MH  - Avoidance Learning/drug effects/*physiology
MH  - Emotions/drug effects/physiology
MH  - Formaldehyde
MH  - Gyrus Cinguli/drug effects/*metabolism
MH  - Inflammation/drug therapy/metabolism
MH  - Male
MH  - Nociceptive Pain/drug therapy/*metabolism/psychology
MH  - Pain Perception/*physiology
MH  - Rats, Sprague-Dawley
MH  - Ribosomal Protein S6 Kinases, 70-kDa/metabolism
MH  - Sirolimus/pharmacology
MH  - Spatial Behavior/drug effects/physiology
MH  - TOR Serine-Threonine Kinases/*antagonists & inhibitors/metabolism
OTO - NOTNLM
OT  - Anterior cingulate cortex
OT  - Conditioned place avoidance
OT  - Conditioned place preference
OT  - Mammalian target of rapamycin
OT  - Pain-related aversion
OT  - Rapamycin
EDAT- 2016/05/11 06:00
MHDA- 2017/12/02 06:00
CRDT- 2016/05/11 06:00
PHST- 2016/01/30 00:00 [received]
PHST- 2016/04/12 00:00 [revised]
PHST- 2016/05/04 00:00 [accepted]
PHST- 2016/05/11 06:00 [entrez]
PHST- 2016/05/11 06:00 [pubmed]
PHST- 2017/12/02 06:00 [medline]
AID - S0166-4328(16)30277-7 [pii]
AID - 10.1016/j.bbr.2016.05.011 [doi]
PST - ppublish
SO  - Behav Brain Res. 2016 Sep 1;310:51-8. doi: 10.1016/j.bbr.2016.05.011. Epub 2016 
      May 6.