PMID- 27163985 OWN - NLM STAT- MEDLINE DCOM- 20160516 LR - 20210109 IS - 1538-3598 (Electronic) IS - 0098-7484 (Linking) VI - 315 IP - 18 DP - 2016 May 10 TI - Effect of Using the Same vs Different Order for Second Readings of Screening Mammograms on Rates of Breast Cancer Detection: A Randomized Clinical Trial. PG - 1956-65 LID - 10.1001/jama.2016.5257 [doi] AB - IMPORTANCE: Interpreting screening mammograms is a difficult repetitive task that can result in missed cancers and false-positive recalls. In the United Kingdom, 2 film readers independently evaluate each mammogram to search for signs of cancer and examine digital mammograms in batches. However, a vigilance decrement (reduced detection rate with time on task) has been observed in similar settings. OBJECTIVE: To determine the effect of changing the order for the second film reader of batches of screening mammograms on rates of breast cancer detection. DESIGN, SETTING, AND PARTICIPANTS: A multicenter, double-blind, cluster randomized clinical trial conducted at 46 specialized breast screening centers from the National Health Service Breast Screening Program in England for 1 year (all between December 20, 2012, and November 3, 2014). Three hundred sixty readers participated (mean, 7.8 readers per center)-186 radiologists, 143 radiography advanced practitioners, and 31 breast clinicians, all fully qualified to report mammograms in the NHS breast screening program. INTERVENTIONS: The 2 readers examined each batch of digital mammograms in the same order in the control group and in the opposite order to one another in the intervention group. MAIN OUTCOMES AND MEASURES: The primary outcome was cancer detection rate; secondary outcomes were rates of recall and disagreements between readers. RESULTS: Among 1,194,147 women (mean age, 59.3; SD, 7.49) who had screening mammograms (596,642 in the intervention group; 597,505 in the control group), the images were interpreted in 37,688 batches (median batch size, 35; interquartile range [IQR]; 16-46), with each reader interpreting a median of 176 batches (IQR, 96-278). After completion of all subsequent diagnostic tests, a total of 10,484 cases (0.88%) of breast cancer were detected. There was no significant difference in cancer detection rate with 5272 cancers (0.88%) detected in the intervention group vs 5212 cancers (0.87%) detected in the control group (difference, 0.01% points; 95% CI, -0.02% to 0.04% points; recall rate, 24,681 [4.14%] vs 24,894 [4.17%]; difference, -0.03% points; 95% CI, -0.10% to 0.04% points; or rate of reader disagreements, 20,471 [3.43%] vs 20,793 [3.48%]; difference, -0.05% points; 95% CI, -0.11% to 0.02% points). CONCLUSIONS AND RELEVANCE: Interpretation of batches of mammograms by qualified screening mammography readers using a different order vs the same order for the second reading resulted in no significant difference in rates of detection of breast cancer. TRIAL REGISTRATION: isrctn.org Identifier: ISRCTN46603370. FAU - Taylor-Phillips, Sian AU - Taylor-Phillips S AD - Warwick Medical School, the University of Warwick, Coventry, United Kingdom. FAU - Wallis, Matthew G AU - Wallis MG AD - Cambridge Breast Unit, Cambridge Universities NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge, United Kingdom. FAU - Jenkinson, David AU - Jenkinson D AD - Warwick Medical School, the University of Warwick, Coventry, United Kingdom. FAU - Adekanmbi, Victor AU - Adekanmbi V AD - Warwick Medical School, the University of Warwick, Coventry, United Kingdom. FAU - Parsons, Helen AU - Parsons H AD - Warwick Medical School, the University of Warwick, Coventry, United Kingdom. FAU - Dunn, Janet AU - Dunn J AD - Warwick Medical School, the University of Warwick, Coventry, United Kingdom. FAU - Stallard, Nigel AU - Stallard N AD - Warwick Medical School, the University of Warwick, Coventry, United Kingdom. FAU - Szczepura, Ala AU - Szczepura A AD - Warwick Medical School, the University of Warwick, Coventry, United Kingdom. FAU - Gates, Simon AU - Gates S AD - Warwick Medical School, the University of Warwick, Coventry, United Kingdom. FAU - Kearins, Olive AU - Kearins O AD - Screening QA Service (Midland & East), Seaton House, City Link, Nottingham, United Kingdom. FAU - Duncan, Alison AU - Duncan A AD - Warwickshire, Solihull and Coventry Breast Screening Service, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom. FAU - Hudson, Sue AU - Hudson S AD - Peel & Schriek Consulting Limited, London, United Kingdom. FAU - Clarke, Aileen AU - Clarke A AD - Warwick Medical School, the University of Warwick, Coventry, United Kingdom. LA - eng SI - ISRCTN/ISRCTN46603370 GR - 11/25/03/DH_/Department of Health/United Kingdom GR - PDF-2011-04-073/DH_/Department of Health/United Kingdom GR - WMCLAHRC-2014-1/DH_/Department of Health/United Kingdom PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - JAMA JT - JAMA JID - 7501160 SB - IM CIN - JAMA. 2016 May 10;315(18):1951-3. PMID: 27163983 MH - *Attention MH - Breast Neoplasms/*diagnostic imaging MH - Double-Blind Method MH - England MH - Female MH - Humans MH - Logistic Models MH - *Mammography/statistics & numerical data MH - Middle Aged MH - Observer Variation MH - *Radiology/statistics & numerical data MH - Sample Size EDAT- 2016/05/11 06:00 MHDA- 2016/05/18 06:00 CRDT- 2016/05/11 06:00 PHST- 2016/05/11 06:00 [entrez] PHST- 2016/05/11 06:00 [pubmed] PHST- 2016/05/18 06:00 [medline] AID - 2520628 [pii] AID - 10.1001/jama.2016.5257 [doi] PST - ppublish SO - JAMA. 2016 May 10;315(18):1956-65. doi: 10.1001/jama.2016.5257.