PMID- 27164124
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20181202
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 13
IP  - 5
DP  - 2016 May 7
TI  - H-Type Hypertension and C Reactive Protein in Recurrence of Ischemic Stroke.
LID - 10.3390/ijerph13050477 [doi]
LID - 477
AB  - Hypertension with high homocysteine (HHcy) (H-type hypertension) and C reactive 
      protein (CRP) can increase the incidence of ischemic stroke. However, it is not 
      clear whether recurrent ischemic stroke (RIS) is related to H-type hypertension 
      and CRP. The present study investigated the correlation of H-type hypertension 
      and CRP level with RIS. Totally, 987 consecutive patients with acute ischemic 
      stroke were recruited in a teaching hospital in Henan province, China during 
      March 2014 to March 2015. The demographic and clinical characteristics and blood 
      biochemical parameters of patients were analyzed. Elevated levels of CRP and 
      homocysteine (Hcy) were defined as >8.2 mg/L and 10 mumol/L, respectively. Among 
      the 987 patients, 234 were RIS. Thirty-eight percent of RIS patients had elevated 
      CRP level and 91.5% of RIS patients had HHcy. In multivariate analysis, adjusted 
      odds ratio (OR) of RIS in patients aged >/=60 years was 1.576 (95% CI: 
      1.125-2.207), in male patients 1.935 (95% CI: 1.385-2.704), in patients with 
      diabetes 1.463 (95% CI: 1.037-2.064), CRP levels 1.013 (95% CI: 1.006-1.019), 
      simple hypertension 3.370 (95% CI: 1.15-10.183), and H-type hypertension 2.990 
      (95% CI: 1.176-7.600). RIS was associated with older age, male, diabetes, H-type 
      hypertension and CRP. Controlling H-type hypertension and CRP level may reduce 
      the risk of RIS.
FAU - Zhang, Qing
AU  - Zhang Q
AD  - Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, 
      China. zq71200@163.com.
FAU - Qiu, De-Xing
AU  - Qiu DX
AD  - Guangming New District People's Hospital & Community Health Service 
      Management Center of Guangming Area, Shenzhen 518000, China. qiudexing66@139.com.
FAU - Fu, Rong-Li
AU  - Fu RL
AD  - Internal Medicine-Neurology, Huaihe Hospital, Henan University, Kaifeng 475000, 
      China. 15225475536@163.com.
FAU - Xu, Tian-Fen
AU  - Xu TF
AD  - Basical School, Guangzhou Medical University, Guangzhou 510180, China. 
      xutianfen01@sina.com.
FAU - Jing, Meng-Juan
AU  - Jing MJ
AD  - Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, 
      China. jing53905@163.com.
FAU - Zhang, Hui-Shan
AU  - Zhang HS
AD  - Department of Preventive Medicine, School of Public Health, Guangzhou Medical 
      University, Guangzhou 510180, China. zhanghuishan25@163.com.
FAU - Geng, He-Hong
AU  - Geng HH
AD  - Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, 
      China. 15226003150@163.com.
FAU - Zheng, Long-Chao
AU  - Zheng LC
AD  - Department of Public Health, School of Public Health, Graduate School of Guizhou 
      Medical University, Guiyang 550025, China. zlc3050@163.com.
FAU - Wang, Pei-Xi
AU  - Wang PX
AD  - Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, 
      China. peixi001@163.com.
AD  - Department of Preventive Medicine, School of Public Health, Guangzhou Medical 
      University, Guangzhou 510180, China. peixi001@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160507
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Brain Ischemia/*blood/epidemiology
MH  - C-Reactive Protein/*analysis
MH  - China/epidemiology
MH  - Diabetes Mellitus/blood/epidemiology
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hypertension/*blood/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Recurrence
MH  - Stroke/*blood/epidemiology
PMC - PMC4881102
OTO - NOTNLM
OT  - C reactive protein
OT  - H-type hypertension
OT  - recurrence ischemic stroke
EDAT- 2016/05/11 06:00
MHDA- 2017/07/25 06:00
PMCR- 2016/05/01
CRDT- 2016/05/11 06:00
PHST- 2016/03/07 00:00 [received]
PHST- 2016/04/27 00:00 [revised]
PHST- 2016/05/04 00:00 [accepted]
PHST- 2016/05/11 06:00 [entrez]
PHST- 2016/05/11 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - ijerph13050477 [pii]
AID - ijerph-13-00477 [pii]
AID - 10.3390/ijerph13050477 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2016 May 7;13(5):477. doi: 
      10.3390/ijerph13050477.