PMID- 27164713
OWN - NLM
STAT- MEDLINE
DCOM- 20170428
LR  - 20220330
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 86
IP  - 19
DP  - 2016 May 10
TI  - Evaluation of the 2015 diagnostic criteria for neuromyelitis optica spectrum 
      disorder.
PG  - 1772-9
LID - 10.1212/WNL.0000000000002655 [doi]
AB  - OBJECTIVE: To evaluate the application of the 2015 International Panel for NMO 
      Diagnosis (IPND) criteria to consecutive cases of neuromyelitis optica spectrum 
      disorder (NMOSD) in a large cohort of individuals with CNS inflammatory diseases. 
      METHODS: In total, 594 patients with CNS inflammatory diseases were included. 
      Rigorous confirmation of the patients' aquaporin-4 immunoglobulin G antibodies 
      (AQP4-IgG) status throughout the disease duration (mean 9.2 +/- 5.7 years) using 
      repeated assays, including ELISA and cell-based assay, was performed. RESULTS: A 
      total of 252 patients fulfilled the IPND criteria (AQP4-IgG positive: 226 [90%], 
      AQP4-IgG negative: 26 [10%]). Of these, 136 (54%) patients met the 2006 
      neuromyelitis optica criteria. When we assumed an unknown AQP4-IgG status in the 
      confirmed NMOSD group with AQP4-IgG, 162 of 226 (72%) patients with AQP4-IgG were 
      classified as having NMOSD by the IPND criteria. The majority of patients were 
      diagnosed with NMOSD within 2 years of onset (73%) or after a second attack 
      (72%). Acute myelitis (83%) and optic neuritis (65%) were the most common 
      clinical features throughout the disease duration. Optic neuritis (42%) was the 
      most common initial manifestation, followed by acute myelitis (38%) and area 
      postrema syndrome (14%). CONCLUSIONS: The IPND criteria well-reflected the 
      broader clinical spectrum of NMOSD and markedly improved the diagnostic yield 
      compared to the previous criteria, even in patients with an unknown AQP4-IgG 
      status.
CI  - (c) 2016 American Academy of Neurology.
FAU - Hyun, Jae-Won
AU  - Hyun JW
AD  - From the Department of Neurology, Research Institute and Hospital of National 
      Cancer Center, Goyang, Korea.
FAU - Jeong, In Hye
AU  - Jeong IH
AD  - From the Department of Neurology, Research Institute and Hospital of National 
      Cancer Center, Goyang, Korea.
FAU - Joung, AeRan
AU  - Joung A
AD  - From the Department of Neurology, Research Institute and Hospital of National 
      Cancer Center, Goyang, Korea.
FAU - Kim, Su-Hyun
AU  - Kim SH
AD  - From the Department of Neurology, Research Institute and Hospital of National 
      Cancer Center, Goyang, Korea.
FAU - Kim, Ho Jin
AU  - Kim HJ
AD  - From the Department of Neurology, Research Institute and Hospital of National 
      Cancer Center, Goyang, Korea. hojinkim@ncc.re.kr.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20160413
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (AQP4 protein, human)
RN  - 0 (Aquaporin 4)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Aquaporin 4/immunology
MH  - Diagnosis, Differential
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoglobulin G/metabolism
MH  - Male
MH  - Neuromyelitis Optica/*diagnosis/physiopathology
MH  - Retrospective Studies
EDAT- 2016/05/11 06:00
MHDA- 2017/04/30 06:00
CRDT- 2016/05/11 06:00
PHST- 2015/09/23 00:00 [received]
PHST- 2016/01/28 00:00 [accepted]
PHST- 2016/05/11 06:00 [entrez]
PHST- 2016/05/11 06:00 [pubmed]
PHST- 2017/04/30 06:00 [medline]
AID - WNL.0000000000002655 [pii]
AID - 10.1212/WNL.0000000000002655 [doi]
PST - ppublish
SO  - Neurology. 2016 May 10;86(19):1772-9. doi: 10.1212/WNL.0000000000002655. Epub 
      2016 Apr 13.