PMID- 27165121 OWN - NLM STAT- MEDLINE DCOM- 20180105 LR - 20181113 IS - 1573-2509 (Electronic) IS - 0920-9964 (Print) IS - 0920-9964 (Linking) VI - 174 IP - 1-3 DP - 2016 Jul TI - Traumatic brain injury in individuals at clinical high risk for psychosis. PG - 77-81 LID - S0920-9964(16)30192-X [pii] LID - 10.1016/j.schres.2016.04.041 [doi] AB - BACKGROUND: Recent research suggests that a traumatic brain injury (TBI) can significantly increase the risk of later development of psychosis. However, it is unknown whether people at clinical high risk (CHR) of psychosis have experienced TBI at higher rates, compared to otherwise healthy individuals. This study evaluated the prevalence of mild TBI, whether it was related to past trauma and the relationship of mild TBI to later transition to psychosis. METHODS: Seven-hundred forty-seven CHR and 278 healthy controls (HC) were assessed on past history of mild TBI, age at first and last injury, severity of worst injury and number of injuries using the Traumatic Brain Injury Interview. Attenuated psychotic symptoms were assessed with the Scale of Psychosis-risk Symptoms. IQ was estimated using the Wechsler Abbreviated Scale of Intelligence and past trauma and bullying were recorded using the Childhood Trauma and Abuse Scale. RESULTS: CHR participants experienced a mild TBI more often than the HC group. CHR participants who had experienced a mild TBI reported greater total trauma and bullying scores than those who had not, and those who experienced a mild TBI and later made the transition to psychosis were significantly younger at the age at first and most recent injury than those who did not. CONCLUSION: A history of mild TBI is more frequently observed in CHR individuals than in HC. Inclusion or study of CHR youth with more severe TBI may provide additional insights on the relationship between TBI and later transition to psychosis in CHR individuals. CI - Copyright (c) 2016 Elsevier B.V. All rights reserved. FAU - Deighton, Stephanie AU - Deighton S AD - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada. FAU - Buchy, Lisa AU - Buchy L AD - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada. FAU - Cadenhead, Kristin S AU - Cadenhead KS AD - Department of Psychiatry, UCSD, La Jolla, CA, United States. FAU - Cannon, Tyrone D AU - Cannon TD AD - Department of Psychology, Yale University, New Haven, CT, United States. FAU - Cornblatt, Barbara A AU - Cornblatt BA AD - Department of Psychiatry, Zucker Hillside Hospital, Long Island, NY, United States. FAU - McGlashan, Thomas H AU - McGlashan TH AD - Department of Psychiatry, Yale University, New Haven, CT, United States. FAU - Perkins, Diana O AU - Perkins DO AD - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, United States. FAU - Seidman, Larry J AU - Seidman LJ AD - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, MA, United States. FAU - Tsuang, Ming T AU - Tsuang MT AD - Department of Psychology, Yale University, New Haven, CT, United States. FAU - Walker, Elaine F AU - Walker EF AD - Departments of Psychology and Psychiatry, Emory University, Atlanta, GA, United States. FAU - Woods, Scott W AU - Woods SW AD - Department of Psychiatry, Yale University, New Haven, CT, United States. FAU - Bearden, Carrie E AU - Bearden CE AD - Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, United States; Department of Psychology, UCLA, Los Angeles, CA, United States. FAU - Mathalon, Daniel AU - Mathalon D AD - Department of Psychiatry, University of California, San Francisco, San Francisco, CA, United States. FAU - Addington, Jean AU - Addington J AD - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada. Electronic address: jmadding@ucalgary.ca. LA - eng GR - U01 MH082022/MH/NIMH NIH HHS/United States GR - U01 MH081984/MH/NIMH NIH HHS/United States GR - UL1 TR001863/TR/NCATS NIH HHS/United States GR - U01 MH081902/MH/NIMH NIH HHS/United States GR - P50 MH080272/MH/NIMH NIH HHS/United States GR - U01 MH081988/MH/NIMH NIH HHS/United States GR - P50 MH066286/MH/NIMH NIH HHS/United States GR - U01 MH076989/MH/NIMH NIH HHS/United States GR - K24 MH076191/MH/NIMH NIH HHS/United States GR - R01 MH060720/MH/NIMH NIH HHS/United States GR - U01 MH081928/MH/NIMH NIH HHS/United States GR - U01 MH081857/MH/NIMH NIH HHS/United States GR - U01 MH082004/MH/NIMH NIH HHS/United States GR - U01 MH081944/MH/NIMH NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural DEP - 20160507 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Adolescent MH - Analysis of Variance MH - Brain Injuries, Traumatic/*complications/epidemiology MH - Bullying MH - Child MH - Female MH - Humans MH - Male MH - Psychiatric Status Rating Scales MH - Psychotic Disorders/*complications/epidemiology MH - Retrospective Studies MH - Risk MH - Severity of Illness Index MH - Stress, Psychological/complications/epidemiology MH - Wechsler Scales MH - Young Adult PMC - PMC5037435 MID - NIHMS785175 OTO - NOTNLM OT - Clinical high risk OT - Psychosis OT - Traumatic brain injury COIS- The authors report no conflict of interest. EDAT- 2016/05/12 06:00 MHDA- 2018/01/06 06:00 PMCR- 2017/07/01 CRDT- 2016/05/12 06:00 PHST- 2016/02/18 00:00 [received] PHST- 2016/04/21 00:00 [revised] PHST- 2016/04/25 00:00 [accepted] PHST- 2016/05/12 06:00 [entrez] PHST- 2016/05/12 06:00 [pubmed] PHST- 2018/01/06 06:00 [medline] PHST- 2017/07/01 00:00 [pmc-release] AID - S0920-9964(16)30192-X [pii] AID - 10.1016/j.schres.2016.04.041 [doi] PST - ppublish SO - Schizophr Res. 2016 Jul;174(1-3):77-81. doi: 10.1016/j.schres.2016.04.041. Epub 2016 May 7.