PMID- 27165867
OWN - NLM
STAT- MEDLINE
DCOM- 20170711
LR  - 20170713
IS  - 0065-1419 (Print)
IS  - 0065-1419 (Linking)
VI  - 122
DP  - 2016
TI  - Mechanism of Traumatic Brain Injury at Distant Locations After Exposure to Blast 
      Waves: Preliminary Results from Animal and Phantom Experiments.
PG  - 3-7
LID - 10.1007/978-3-319-22533-3_1 [doi]
AB  - Purpose Primary blast-induced traumatic brain injury (bTBI) is the least 
      understood of the four phases of blast injury. Distant injury induced by the 
      blast wave, on the opposite side from the wave entry, is not well understood. 
      This study investigated the mechanism of distant injury in bTBI. Materials and 
      Methods Eight 8-week-old male Sprague-Dawley rats were divided into two groups: 
      group 1 served as the control group and did not receive any shock wave (SW) 
      exposure; group 2 was exposed to SWs (12.5 +/- 2.5 MPa). Propagation of SWs within 
      a brain phantom was evaluated by visualization, pressure measurement, and 
      numerical simulation. Results Intracerebral hemorrhage near the ignition site and 
      elongation of the distant nucleus were observed, despite no apparent damage 
      between the two locations in the animal experiment. Visualization, pressure 
      measurement, and numerical simulation indicated the presence of complex wave 
      dynamics accompanying a sudden increase in pressure, followed by negative 
      pressure in the phantom experiment. Conclusion A local increase in pressure above 
      the threshold caused by interference of reflection and rarefaction waves in the 
      vicinity of the brain-skull surface may cause distant injury in bTBI.
FAU - Nakagawa, Atsuhiro
AU  - Nakagawa A
AD  - Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 
      Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. 
      nakg_neurosurg@yahoo.co.jp.
FAU - Ohtani, Kiyonobu
AU  - Ohtani K
AD  - Institute of Fluid Science, Tohoku University, Miyagi, Japan.
FAU - Goda, Keisuke
AU  - Goda K
AD  - Department of Chemistry, School of Science, University of Tokyo, Tokyo, Japan.
AD  - Department of Electrical Engineering, University of California, Los Angeles, USA.
FAU - Kudo, Daisuke
AU  - Kudo D
AD  - Department of Emergency Medicine and Critical Care, Tohoku University Graduate 
      School of Medicine, Miyagi, Japan.
FAU - Arafune, Tatsuhiko
AU  - Arafune T
AD  - Division of Electrical and Mechanical Engineering, School of Science and 
      Engineering, Tokyo Denki University, Tokyo, Japan.
FAU - Washio, Toshikatsu
AU  - Washio T
AD  - National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan.
FAU - Tominaga, Teiji
AU  - Tominaga T
AD  - Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 
      Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
LA  - eng
PT  - Journal Article
PL  - Austria
TA  - Acta Neurochir Suppl
JT  - Acta neurochirurgica. Supplement
JID - 100962752
SB  - IM
MH  - Animals
MH  - Blast Injuries/*etiology/pathology
MH  - Brain/pathology
MH  - Brain Injuries, Traumatic/*etiology/pathology
MH  - Computer Simulation
MH  - *Explosions
MH  - Male
MH  - *Phantoms, Imaging
MH  - *Pressure
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Blast injury
OT  - Neurocritical care
OT  - Shock wave
OT  - Traumatic brain injury
EDAT- 2016/05/12 06:00
MHDA- 2017/07/14 06:00
CRDT- 2016/05/12 06:00
PHST- 2016/05/12 06:00 [entrez]
PHST- 2016/05/12 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
AID - 10.1007/978-3-319-22533-3_1 [doi]
PST - ppublish
SO  - Acta Neurochir Suppl. 2016;122:3-7. doi: 10.1007/978-3-319-22533-3_1.